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#409: How to LIVE YOUNG for a Lifetime: The Real Secrets of Mindset, Medicine & Longevity | Personalized Health Explained With Dr. Jeffrey Gladden

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Feb 3, 2026

Guest

Jeffrey Gladden

Dr. Jeffrey Gladden, an interventional cardiologist turned longevity and age-management physician who now focuses on personalized medicine and psycho-spiritual health. He discusses reclaiming vitality through targeted testing and individualized treatments. Topics include mindset shifts for lifelong youth, five domains of exponential health, insulin resistance and metabolic testing, meditation and internal environment, and safe hormone and advanced therapy preparation.

01:18:57

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ANECDOTE

Doctor's Personal Health Turning Point

Jeffrey Gladden hit a midlife health wall with fatigue, brain fog, weight gain and depression despite 'normal for your age' labs.
He decoded his thyroid genetics, added T3/T4 and hormones, and regained energy and muscle within weeks.

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INSIGHT

Aging Is Exponential — Treat It That Way

Aging is exponential, not linear, so linear fixes (diet, exercise, peptides) often miss root causes.
Gladden proposes five circles (life energy, longevity hallmarks, health systems, performance, environment) to create exponential responses.

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ADVICE

Personalize Diet, Rotate Foods Often

Personalize diet by deconstructing genetics, microbiome, digestion and preferences before prescribing a specific eating pattern.
Vary foods to expand gut tolerance and avoid immune reactivity by rotating different vegetables and staples.

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Jeffrey's shift from cardiology to longevity

04:00 • 5min

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Reclaiming health through targeted testing

09:22 • 2min

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Vision: youthful body with a wise mind

11:48 • 6min

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Longevity mindset: growth and quantum thinking

17:19 • 2min

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Five circles of exponential health

19:27 • 2min

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Individualization over one-size diets

21:33 • 8min

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Carbohydrate tolerance and amylase genetics

29:12 • 9min

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Environment: external toxins and internal stress

38:40 • 1min

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Meditation, theta states and healing

From efforting to receiving for calm

45:31 • 3min

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Internal environment as the superpower

48:03 • 2min

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Trauma, meaning and post-traumatic growth

50:03 • 7min

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Robustness, resilience and anti-fragility

57:14 • 3min

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Top predictors: parasympathetic tone, VO2 and hormones

01:00:10 • 6min

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Safe hormone optimization and cancer risk

01:05:57 • 3min

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Preparing the body for advanced therapies

01:08:32 • 3min

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Mitochondrial tools: urolithin A and NAD nuance

01:11:22 • 2min

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Testing pitfalls and biometric baselines

01:12:56 • 4min

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Biological age is a mosaic, not a number

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100 Is the New 30

Jeffrey Gladden

Today, I'm joined by the inspiring Dr. Jeffrey Gladden—a trailblazer in longevity medicine who once spent decades as an interventional cardiologist, only to challenge everything he knew after his own health hit a wall. Dr. Gladden opens up about the moment he refused to accept "normal for your age" as a diagnosis, launching himself into the world of functional and age-management medicine to reclaim his vitality and help others do the same.

Episode Timestamps:

Welcome and episode introduction ... 00:00:00

Health crisis and discovering personal optimization ... 00:07:05

From "sick care" to health optimization ... 00:10:46

Vision for personalized, youthful longevity ... 00:12:17

Personalized medicine: why one size doesn't fit all ... 00:16:00

Linear versus exponential aging; fixing a flawed approach ... 00:18:02

Five circles of exponential health: key longevity domains ... 00:19:23

Curiosity, growth mindset, and quantum thinking in longevity ... 00:22:22

Why individualization is crucial for diet and interventions ... 00:28:52

Insulin resistance: the hidden driver of aging ... 00:33:41

Environmental and internal (psychospiritual) factors in health ... 00:38:40

Healing through meditation, stress management, and flow ... 00:41:15

Robustness, resilience, and anti-fragility as longevity superpowers ... 00:57:09

Safe, personalized hormone therapy and the importance of tracking ... 01:03:33

Integrating mindset, purpose, and psycho-spiritual work ... 01:08:50

Peptides and advanced therapies: preparing for optimal results ... 01:09:56

Common test misconceptions in longevity medicine ... 01:12:56

Debunking the myth of single biological age ... 01:16:38

Resources, connect with Dr. Gladden, and closing ... 01:18:09

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