The Thyroid (and Hormone) Fixer Podcast: Thyropause, Menopause, Metabolism and How to Fix It

499. Repurposed Drugs, Peptides and Anabolics for Weight Loss and Longevity with Dr. Elizabeth Yurth

33 snips
Feb 18, 2025
Guest
Elizabeth Yurth
Dr. Elizabeth Yurth, a longevity physician who leads the Boulder Longevity Institute, discusses repurposed drugs, peptides, and anabolics for weight loss and longevity. She covers microdosing tadalafil, metformin vs GLP‑1 strategies, rapamycin cycling, thymic peptides and repair peptides like BPC‑157, and anabolic options such as oxandrolone and nandrolone.
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INSIGHT

Microdosed Cialis Improves Vascular Health And Mitochondria

  • Low-dose tadalafil (5 mg/day) repurposed from erectile dysfunction improves vascular flow, mitochondrial function, inflammation, and thyroid perfusion in both men and women.
  • Elizabeth Yurth reports ~70% of her patients use it for neuroprotection, muscle preservation, Raynaud relief, and improved exercise performance.
INSIGHT

Metformin Extends Life But Can Hinder Muscle

  • Metformin activates AMPK and suppresses mTOR which may extend lifespan but also impairs muscle growth, making it less ideal for those emphasizing resistance training.
  • Yurth prefers microdosed GLP-1 agonists for longevity because they upregulate AMPK without chronically blocking mTOR and preserve muscle when paired with adequate protein and resistance training.
ADVICE

Microdose GLP‑1s For Longevity And Muscle Protection

  • Use GLP-1 agonists at low microdoses for neuroprotection, cardiometabolic benefits, and longevity rather than only high doses for weight loss.
  • Yurth microdoses weekly (often a quarter or less of weight-loss doses) and emphasizes adequate protein to prevent muscle loss.
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