Extend Podcast with Darshan Shah, MD

140. Dr. Kelly Casperson: The Hormone Truth About Women's Longevity

Feb 19, 2026
Dr. Kelly Casperson, a board-certified urologist, sex educator, and author helping women reclaim hormone and sexual health. She reframes aging as hormone and muscle loss. Topics include why estrogen, progesterone, and testosterone matter systemically. They debunk WHI misconceptions, explore vaginal estrogen, wearables and biomarkers, and discuss muscle, blood flow, exercise, and responsive desire.
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INSIGHT

Muscle And Hormones Drive Aging

  • Aging-related decline is largely driven by loss of muscle and hormones rather than chronological age.
  • Preserving muscle and replacing lost hormones can change aging trajectories and reduce frailty.
ANECDOTE

One Patient Changed Her Career

  • A single patient with a sexless marriage redirected Kelly Casperson's career toward women's sexual and hormone health.
  • That encounter led her to start the You Are Not Broken podcast and pursue public education.
INSIGHT

WHI Fear Distorted HRT Narrative

  • The WHI study was widely misinterpreted and created enduring fear of hormone therapy.
  • The actual data are nuanced and modern transdermal estradiol has a different safety profile than the WHI drugs.
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