Siim Land Podcast #372 Glycine and Protein for Longevity; Genetic Bottlenecks and MTHFR - Chris Masterjohn PhD
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Aug 22, 2023 
Chris Masterjohn, longevity and genetics expert, discusses the role of glycine and methionine in promoting longevity. They explore the risks of high homocysteine, optimal protein ratios, and the benefits of taurine supplementation. They also delve into the importance of identifying genetic bottlenecks for optimal performance and longevity. The podcast concludes with strategies for longevity, self-experimentation, and the potential for reversing biological aging.
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Build Peak Muscle And Bone Early
- Ensure high enough protein intake to maintain peak muscle and bone mass starting young.
- Aim to maximize peak muscle and bone by age 25–30 to reduce later-life fracture and sarcopenia risk.
Methionine–Glycine Balance Matters
- Balance between sulfur amino acids (methionine/cysteine) and glycine matters for longevity and health.
- Traditional nose-to-tail eating provided more glycine from collagen and better methionine:glycine balance.
Glycine Synthesis Needs Carbs And Folate
- Endogenous glycine synthesis depends on carbohydrate intake and folate status.
- Low-carb, low-folate diets (e.g., steak-only carnivore) increase glycine requirements and impair synthesis.