The Jesse Chappus Show 677: You Won't Fix Insulin Resistance Until You Do This... | Dr. Annette Bosworth
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Nov 4, 2025 
Dr. Annette Bosworth, known as Dr. Boz, is an expert in metabolic and brain health. In this enlightening discussion, she breaks down how insulin resistance drives weight gain and disease. She prescribes a low-carb diet to kickstart ketogenesis and discusses the critical role of magnesium for mitochondrial health. Dr. Bosworth also shares tips on time-restricted eating and reveals her personal success with shedding pounds. Plus, she highlights the importance of monitoring glucose for women facing insulin resistance!
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Stop Eating Every Two Hours
- Avoid frequent eating driven by insulin; it creates blood sugar rollercoaster and constant hunger.
- Switch fuel to fat to reduce hunger spikes and downgrade insulin's dominance.
Sugar Destroys Vascular Protection
- Repeated glucose spikes damage the glycocalyx and make arteries sticky, impairing cholesterol recycling.
- That damage seeds cholesterol parking in artery walls and initiates atherosclerotic plaque formation.
Make Fat ~80% Of Early Calories
- Do aim for ~80% of calories from fat early in ketosis to maintain ketone circulation and hormone mobilization.
- Use egg yolks, bacon, and fatty proteins; avoid hidden carbs in fruits and many vegetables.