The Art of Being Well The New Microbiome-Metabolism Science & The GLP-1 Connection You Need to Know | Colleen Cutcliffe
Sep 25, 2025
Colleen Cutcliffe, PhD, co-founder of Pendulum and a leading microbiome scientist, dives into the incredible connections between gut health and metabolic well-being. She explains how keystone strains like Akkermansia muciniphila influence GLP-1 levels and highlight the role of diet in shaping our microbiomes. Colleen discusses the impact of antibiotics on gut resilience, the benefits of fermented foods, and natural ways to enhance GLP-1 signaling. Tune in to discover how gut health can transform your hormones, cravings, and overall vitality!
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Metabolic Health Tied To Specific Microbial Functions
- People with metabolic syndrome show specific microbial depletions affecting fiber-to-SCFA pathways.
- Restoring these functions improves digestion, energy, cravings, and metabolic responses.
Target SCFA Producers For Metabolic Gain
- Support short-chain fatty acid production by growing butyrate and propionate producers like Clostridium butyricum and Akkermansia.
- Prioritize diverse fibers, polyphenols, and specific probiotics to restore these pathways.
Rebuild Tolerance Before Expanding Foods
- If fiber-rich foods trigger symptoms, start by reducing triggers then rebuild tolerance gradually.
- Use micro-dosed targeted probiotics and slowly reintroduce prebiotics or fiber to restore resilience.