The Curbsiders Internal Medicine Podcast #480 Hypermobility with Dr. Linda Bluestein
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Apr 21, 2025 AI Snips
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Skin Signs in EDS Subtypes
- Soft, velvety, doughy skin is a subjective but important sign of connective tissue disorders.
- Excessively stretchy skin suggests rarer EDS subtypes, particularly vascular EDS, which require genetic testing.
Diagnosing POTS with Orthostatic Testing
- Use a 10-minute orthostatic vital signs test with supine rest then standing leaning against a wall.
- Look for heart rate increase ≥30 bpm in adults as a criterion for diagnosing POTS and related dysautonomia.
Neurologic Links to Hypermobility
- People with hypermobility have higher rates of neurodivergent conditions including ADHD and autism.
- Migraine, cranial nerve symptoms, and increased Chiari malformation prevalence are common in this population.