The Jesse Chappus Show 576: Your Doctor Is Wrong About Cholesterol & Heart Disease! | Dr. Malcolm Kendrick
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Dec 26, 2023 Dr. Malcolm Kendrick, a General Practitioner and bestselling author, challenges the cholesterol hypothesis and discusses the role of saturated fat and LDL cholesterol in heart disease. He explains the anatomy of plaque in arteries, the importance of protecting the glycocalyx, and the real causes of heart disease. Kendrick also shares practical tips to repair the endothelium and highlights the flawed understanding of LDL cholesterol and heart disease.
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France Sparked Skepticism
- Kendrick recounts noticing France had high saturated fat but low heart disease compared to Scotland.
- That discrepancy sparked his long investigation into the diet–cholesterol narrative.
Plaque Is Mostly Clotting Debris
- Plaques contain fibrin, red and white blood cells, and varied blood components, not just cholesterol.
- Longstanding plaques often contain little identifiable LDL, contradicting simplistic 'cholesterol plaque' views.
Lp(a) Acts Like A Stubborn Patch
- Lipoprotein(a) — Lp(a) — is LDL with an extra apolipoprotein(a) that binds damaged artery surfaces.
- Lp(a) resists clot breakdown by inhibiting plasminogen activation, making clots harder to remove and promoting persistent plaque.