JAMA Editors' Summary Heart Transplant and a New Organ Preservation Technique, US Obesity Prevalence, Deprescribing for Older Adults, and more
Jan 30, 2026
A tour of cutting-edge transplant techniques and ethical questions around donation. Projections of rising U.S. obesity and persistent disparities. Trials testing EHR nudges to reduce medications in older adults. Several studies on AI use and calls for transparency in medical publishing. Policy proposals for device transparency and concerns about transplant access.
AI Snips
Chapters
Transcript
Episode notes
RE-UP Enables Safe DCD Heart Transplants
- Rapid recovery with extended ultra-oxygenated preservation (RE-UP) avoided donor heart reanimation while maintaining safety in a 24-recipient case series.
- The technique yielded 96% 30-day survival with low severe graft dysfunction and early rejection rates.
Obesity Projected To Affect Nearly Half Of Adults
- U.S. adult obesity rose from 19% in 1990 to 42.5% in 2022 with large variation by state, race, sex, and age.
- Projections estimate nearly half of adults will have obesity by 2035 with persistent disparities, notably high prevalence among non-Hispanic Black females and in Midwest and Southern states.
Use EHR Nudges To Promote Deprescribing
- Use targeted EHR behavioral nudges to reduce potentially inappropriate medications in adults 65 and older.
- The pre-commitment EHR intervention produced the largest increase in deprescribing versus usual care in the randomized trial.