Siim Land Podcast #461 Top Longevity Supplements Analyzed by PhD Experts - Dr Greg Potter and Dr Nicolas Verhoeven
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Jul 12, 2025 
Dr. Nicolas Verhoeven, aka Physionic, and Dr. Greg Potter, both PhD experts in longevity supplements, dive deep into the world of dietary nutraceuticals. They discuss underrated supplements like taurine and ergothioneine, and tackle the importance of timing for supplement intake. The duo explores the science behind omega-3s, vitamin D, and the potential of new players like nobilitin and trace lithium. Their insights also touch on the interplay between supplements and genetics, and how these factors can shape health and aging.
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Supplements May Blunt Exercise Gains
- Some supplements like antioxidants and metformin can blunt exercise benefits by reducing inflammation signals.
- The impact varies by supplement, and evidence mainly shows effects on molecular signaling rather than consistent functional outcomes.
NAD+ Precursors: Disappointing Trials
- NAD+ precursors raise NAD levels but human clinical trials show mostly disappointing effects on health outcomes.
- Effectiveness may be hampered by testing nonspecific biomarkers and heterogeneous human responses.
Alternative NAD+ Boosting Approaches
- Boosting NAD through targeting enzymes (CD38, NNMT) via plant extracts may offer mild benefits.
- Systems biology approaches are promising but current effects and statistics in studies are modest or borderline significant.
