Hosted by Lester Nare and Krishna Choudhary, this episode has two main stories: an astrophysics update on a candidate “dark galaxy” in the Perseus Cluster (a halo that’s ~99.9% dark matter), and a major Alzheimer’s mechanism paper tracing how exercise protects the brain by repairing the blood–brain barrier—with an actionable drug-like path already emerging.
Summary
Candidate dark galaxy — Hubble + Euclid stacking and globular clusters reveal an ultra-faint halo that could test missing satellites and the cusp–core problem (and even “fuzzy dark matter”).
Exercise → Alzheimer’s mechanism — UCSF links a liver enzyme (GPLD1) to BBB repair via TNAP regulation, plus an oral TNAP inhibitor (SBI-425) that mimics the effect in mice.
Rundown — Rubin Observatory’s real-time alert engine, AI-accelerated magnet discovery, a climate-corrected Easter Island history, and the Boba-Kiki effect in baby chicks.
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