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TWiEVO 84: Decoding our defenses to the Black Death

This Week in Evolution

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Evolution of Immune Responses from the Black Death to COVID

The chapter explores the genetic changes in immune responses over 500 years pre- and post-Black Death, focusing on the role of ERAP2 mutation in the immune system's defense against pathogens like the bubonic plague. It discusses experiments linking history, archaeology, genetics, and human disease outcomes, emphasizing the trade-offs in biology regarding immune defense mechanisms.

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