Dr. Chapa’s OBGYN Clinical Pearls

Diabetic ketoacidosis in pregnancy is an obstetric and medical emergency and therefore requires prompt and aggressive treatment in a specialized care unit. Prompt and aggressive IV fluid management, IV insulin administration, and attention to key electrolytes are foundational to DKA management. In this podcast, we will review the SMFM protocol for DKA management in pregnancy.

Corticosteroid therapy for fetal lung maturity was first endorsed back in 1994. But what do we know about its affect on glycemic levels? Pregnant women with gestational diabetes, and of course pre-existing diabetes, are at higher risk of DKA at “lower” hyperglycemic levels compared to non-pregnant individuals. In this session, we will review the data on the effect of antenatal corticosteroids on the mothers’ glycemic levels.

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Incidence of cerebral palsy is inversely related to gestational age a delivery. The first reported association between fetal exposure to mag sulfate and reduction in perinatal morbidity was published in 1992. Magnesium sulfate for fetal neuroprotection is now standard in women presenting with preterm labor at less than 32 weeks. In this podcast, we will review the data on mag sulfate for fetal neuroprotection and summarize current best practices. Data is taken from the ACOG, SMFM, and Cochrane review on mag sulfate for fetal neuroprotection.

In 1932 a governmental agency called the Public Health Service began working with the Tuskegee Institute to study syphilis in black men. In 1947, when penicillin was discovered as the illness cure, participants in the study were denied treatment in “order to study the natural outcome of disease”. In the early 1970s, the “study” was finally deemed unethical and was stopped. As syphilis cases continue to rise in the US, we must not forget the principles of ethical scientific discovery and not forget those who participated in a study which violated all currently accepted ethical standards.

This is Part 2 of our critical reappraisal of the WHI study. In this episode we will cover the NAMS 2017 guidelines on HRT use. Does hormone therapy increase breast cancer in BRCA carriers? What is the data on ovarian cancer? Dementia? Listen to find out! We will also briefly touch on transdermal hormone replacement therapy, at the end of the podcast.

(Part 1) The media attention surrounding the publication of the initial results of WHI in 2002 led to fear and confusion regarding the use of hormonal therapy (HT) after menopause. In 2006, re-analysis of more complete data seemed to contradict the original findings. This led to a “retraction“ and re-explanation of the original data in 2007. Hormone therapy initiation in older women is NOT the same as initiation in younger women! In this session, we will take a critical look at the original WHI data from 2002 and the complete data and reanalysis released in 2007. We will separate fear from reality! Data for this episode comes from the WHI original trial, NAMS analysis, WHO data, as well as the international menopause society.

Nuchal cord (NC) is common, and the vast majority of term deliveries with nuchal cord have normal outcomes. However, nuchal cord associated fetal morbidity is closely correlated to the number on nuchal cords present and the degree of “strangulation”/tightness. Even Hippocrates noted that nuchal cords could be associated with fetal loss in one of his writings, circa 370 BC. In this session, we will review data from the ACOG executive statement on neonatal encephalopathy, as well as a literature review on NCs by Peesay (2017) from the Journal of Maternal Health, Neonatology, and Perinatology.

Umbilical Artery Doppler studies are a valuable tool to assess vital well-being in the growth restricted fetus. What are the indices that are evaluated? What is the management when abnormal results are noted? In this session, we will review fetal doppler umbilical artery velocimetry. Clinical management based upon findings will also be discussed. Dated taken from SMFM Clinical Briefs and ACOG practice bulletin 145.

In this episode, which is part 2, we will cover the role of “prophylactic” red blood cell transfusion during pregnancy. We will also cover the medical management of sickle cell crisis, and wrap up the episode with notes on intrapartum and postpartum care.