Cardiac Consult: A Cleveland Clinic Podcast for Healthcare Professionals

In the first-in-human phase 1 trial of lepodisiran, a novel short-interfering RNA (siRNA) therapy, levels of lipoprotein(a) (Lp(a)) were reduced below the lowest limit of quantitation for nearly nine months. Steven Nissen, MD, summarizes these findings that were presented in a late-breaking science session at the American Heart Association Scientific Sessions 2023 and simultaneously published online in JAMA.

Following a case presentation, Mazen Hanna, MD, Co-Director of the Cleveland Clinic's Amyloidosis Center, provides an overview of ATTR Amyloidosis, reviewing pathophysiology and types.

This podcast explores the treatment and management of infective endocarditis (IE) from an infectious disease perspective. Topics include medical and surgical treatments for IE in patients with substance use disorder, the importance of early diagnosis and antibiotics, the role of addiction treatment, and the 90-day golden period for better outcomes in patients with injection drug use.

In this episode Bo Xu, MD, discusses multimodality imaging to evaluate suspected infective endocarditis. Haytham Elgharably, MD, provides an overview and reviews indications and optimal timing for cardiac surgery.

There are many considerations for patients requiring reoperation. Marc Gillinov, MD, Faisal Bakaeen, MD, and Shinya Unai, MD, discuss some of these considerations as well as what has led to Cleveland Clinic's success.

Marc Gillinov, MD, Chairman of the Department of Thoracic and Cardiovascular Surgery in the Sydell and Arnold Miller Family Heart, Vascular & Thoracic Institute, provides an overview and update on Cardiovascular and Thoracic Surgery at Cleveland Clinic.

The field of research is continually developing and evolving. One specific area relates to inclusion and exclusion criteria for participants. Eileen Hsich, MD, discusses the importance of recruiting diverse patients.

Sudish Murthy, MD, PhD, provides a Thoracic Surgery Robotics update at Cleveland Clinic's Heart, Vascular and Thoracic Institute.

Oussama Wazni, MD, MBA, and Pasquale Santangeli, MD, PhD, from the Cardiac Electrophysiology and Pacing Section, discuss considerations for managing ventricular tachycardia as a result from cardiomyopathy.

Shinya Unai, MD, provides an update on Cleveland Clinic Heart, Vascular and Thoracic Institute's Cardiac Surgery Reoperations.