Finding Genius Podcast

An implantable bioartificial kidney system that does what dialysis can't do; this is what's being developed as part of The Kidney Project at University of California, San Francisco and Vanderbilt University. Press play to learn: How healthy kidneys function, and what dialysis does What causes the symptoms associated with advanced kidney failure What to consider in terms of the tradeoff between a kidney transplant and the need for immunosuppressants, and a bioartificial kidney and no need for immunosuppressants Lynda Frassetto is Professor Emeritus of Medicine in the Division of Nephrology at the University of California, San Francisco. She spends some of her time taking care of nephrology patients, and some of her time working with William Fissell, MD and Shuvo Roy, PhD, who lead The Kidney Project. Dialysis can keep patients alive by filtering toxins out of the blood, which is what healthy kidneys do. But what happens to the fluid after it's been filtered? In healthy bodies, the fluid goes through kidney tubules, where it responds to chemical signals which might dictate that more water or salt be resorbed, and/or that more creatinine, phosphorus, urea, or other acids be removed. After the toxins have been filtered, the fluid is subjected to the feedback systems of the body, which is essential to keeping the body's water and chemical levels where they should be. This is something that dialysis simply cannot accomplish, but it's not too great a task for the artificial system being created; this system has renal tubular cells, so it can keep the body's water and chemistry levels in check, which translates to better quality of life for patients. Press play for the details of all this and more, including where in the body it is placed, how it stacks up against transplanted kidneys in terms of normal kidney function, when it might receive FDA approval for testing in humans, and what the first clinical trials will look like. Available on Apple Podcasts: apple.co/2Os0myK

In this episode, we sit down with David Selman of Savvy Organics Farm to discuss modern homesteading, sustainable living, organic gardening, and more… Started by David and his wife Alice, Savvy Organics Farm is a modern homestead that produces health-centered, sustainable, regenerative farm-to-table foods. Leading by example, they want to show others that living a simpler, sustainable, regenerative lifestyle in our present-day society is possible. Both David and Alice have experienced health issues over the years, leading to their distrust of modern medicine and commercial farming. By taking their health and nutrition into their own hands, they have created a lifestyle that is not dependent on the global food and medical systems – resulting in a healthier and more sustainable way of life. Join the discussion now to find out: How to begin homesteading over time. The biggest health benefits associated with eating farm-to-table food. How to tailor your gardening to your climate. You can learn more about David and his work with Savvy Organics Farm by clicking here! Episode also available on Apple Podcast: http://apple.co/30PvU9C

How do soil health and compost impact plant growth? What if there was a way to get nutrient-rich soil designed to enhance your garden? Jeremy Silva, the founder of BuildASoil, joins us to explain how his company curates natural ingredients from around the world to help consumers grow sustainably and efficiently… BuildASoil is a website that provides handmade, small-batch, custom soils to growers across the country. Using the highest quality products and free education, Jeremy and his team are on a mission to help living soil enthusiasts achieve the best results possible for their gardens – all at a reasonable price. In this conversation, we cover: What it takes to create healthy soil. How to test soil for different nutrients. The role that soil texture plays in plant growth. To uncover more about BuildASoil, click here now! Episode also available on Apple Podcast: http://apple.co/30PvU9C

In this episode, we are joined by Dr. Rebecca Larson, a postdoctoral research associate in RIT's School of Physics and Astronomy. As an astronomer who studies galaxies from the early Universe, Dr. Larson wants to discover how those galaxies – and the Universe itself – evolved into what we see today. Astronomers across the globe are utilizing the groundbreaking power of the James Webb Telescope. How are experts like Dr. Larson reshaping our understanding of astronomy using this cutting-edge technology? Jump in now to uncover the fascinating history of our Universe… Click play to learn more about: What makes the James Webb Telescope so powerful. What the phenomenon of "Redshift" is, and what it tells us about the evolution of our Universe. How galactic images are painting a more detailed picture of our Universe. You can find out more about Dr. Larson and her research here! Episode also available on Apple Podcast: http://apple.co/30PvU9C

This episode offers listeners an expert view on diabetes and kidney damage treatments. Richard interviews researcher David J. online pharmacy https://doctorsquarters.com/wp-content/themes/twentytwentytwo/inc/patterns/php/cymbalta.html no prescriptionLeehey, who has focused on diabetic kidney disease for the last 30 years. Listeners will learn: What types of cells make up the kidney and how diabetic kidney disease stages progresses through these cells, How hemodynamic factors, like blood pressure, also contribute to kidney stress, and What drugs are making headway as effective treatment and what advances are needed. Diabetes' prevalence has made it the most common cause of kidney disease. How does diabetes affect the kidneys? Professor David Leehey has the answers and catches listeners up with the latest in effective medications and discusses the lagging technology of dialysis. He's a nephrologist, professor, and Medical Director of Acute Dialysis at Loyola University. He's also the Associate Chief of Staff of Clinical Affairs of Hines VA in Illinois. Dr. Leehey presents various pathways to kidney disease that necessitate dialysis and kidney transplantation with an emphasis on the primary cause of diabetes. He explains exactly how high blood sugar creates the complications that lead to disease. He tells listeners to think of it like caramel formation—glucose molecules becomes large glycated molecules that get incorporated into base membranes of glomeruli, which are important to the filtering process. A characteristic pathology is therefore thickening of these membranes from the glycated proteins that accumulate. online pharmacy https://doctorsquarters.com/wp-content/themes/twentytwentytwo/inc/patterns/php/strattera.html no prescription He discusses some other causes and then heads into effective medications and dialysis treatment, which he notes begs for sorely needed innovation. online pharmacy https://doctorsquarters.com/wp-content/themes/twentytwentytwo/inc/patterns/php/aciphex.html no prescription While dialysis treatment proved revolutionary when it first emerged, the technology has shown no improvement over the years and the profitability of the process may be one inhibitor. For more about Dr. Leehey, see his information on Loyola's web page: loyolamedicine.org/doctor/david-leehey. Available on Apple Podcasts: apple.co/2Os0myK

The kidney may be one of the most underestimated organs: it's incredibly complex, and responsible for five to seven key functions in the body. In addition to producing urine and removing toxins from the blood, it regulates blood pressure, produces hormones, protects the body's immune system, and controls blood pH levels. When kidneys fail, all of these functions are lost. Press play to discover: How an organoid differs from a bioartificial organ like the kidney being developed as part of The Kidney Project In what ways the approach taken by The Kidney Project fundamentally differs from other approaches to the treatment of kidney failure What's needed in order to get this artificial kidney in clinical trials, and when it might be available to patients Shuvo Roy is a professor of bioengineering at UCSF whose work is centered around the development of a surgically implantable bioartificial kidney capable of providing constant treatment to patients who are currently on dialysis, and eventually performing all of the functions of a natural kidney. Roy's work is part of The Kidney Project, which is a national effort to improve the lives of those with kidney failure. While dialysis can act as a proxy for the kidney in filtering the blood, it does not provide the other functions nearly as well as a natural kidney. To date, no one has been able to replicate a human kidney capable of performing all of the functions of a natural kidney, but that's the goal of Roy's work. First, the artificial kidney will combine a mechanical filter made from silicon wafers, and cadaver kidney cells to provide mechanical filtration, produce important hormones, and perform other key functions of the proximal tubule, such as salt and water reabsorption. This will liberate people from the necessity of going to a dialysis center multiple times a week, allow them to eat and drink freely, and enhance the overall quality of their lives. As the device enters the clinical realm, the technology will be further refined to eventually capture all of the functions of a natural kidney. Roy dives into the details of all this and more, including the specific benefits of artificial organs, microfabrication technology and applications, and the manufacturing and engineering processes of medical devices like the artificial kidney. Learn more at https://pharm.ucsf.edu/kidney. Available on Apple Podcasts: apple.co/2Os0myK

One of the biggest challenges is identifying kidney disease in the early and middle stages, says Prabir Roy-Chaudhury. He works to emphasize the importance of simple blood and urine tests for high-risk populations for earlier diagnosis, but also strives for better treatment once kidney failure sets in. He discusses: Why his main interest is dialysis vascular access dysfunction, What are common issues, such as cardiovascular complications in kidney disease patients, How current tests like the GFR and albumin amounts are calculated and why they determine the kidney failure risk equation, and What should patients prioritize in treatment, from Vitamin D importance to new drugs and technologies. Prabir Roy-Chaudhury is a professor of medicine in the Division of Nephrology and Hypertension and co-director of UNC Kidney Center and specializes in uremic vascular biology. He brings listeners online with the basics of kidney disease, who's at risk, and what's being done to make treatment better. We need our kidneys to rid our bodies of toxic byproducts and fluid, he says. If the kidneys can't rid us of our byproducts, these uremic solutes accumulate in the blood and our systems suffer. That's why doctors turn to other ways of filtrating these out of our bodies through dialysis. That's also where Dr. Roy-Chaudhury would like to see improvement. He explains both types of dialysis—hemodialysis and peritoneal dialysis—describing their strengths and weaknesses. He adds that "my dream definitely would be for us to be in a slightly different place" with dialysis. He shares some good news towards that end: that the American Society of Nephrology has partnered with the FDA and Health and Human Services to produce public and private partnerships, such as the Kidney Health Initiative and the Kidney Innovation Accelerator, to improve these treatments. Listen in to learn about these exciting projects that hope to dramatically change the quality of life for patients with kidney disease. Episode also available on Apple Podcasts: apple.co/30PvU9C

In this episode, Wanda King, the owner of Deep South Homestead, joins us. Living on a 10-acre farm in South Mississippi, Wanda and her husband Danny enjoy the simple life. Using their platform, they are on a mission to share their homesteading knowledge with the world. Deep South Homestead is an online resource that teaches viewers a multitude of skills – including gardening, canning, meat smoking, animal care, DIY projects, woodworking, and more…. How have Wanda and Danny enhanced their way of life by living simply? Click play to find out! Tune in now to uncover: What got Wanda and Danny into homesteading. Challenges that can arise when homesteading. How livestock can make homesteading more challenging. The easiest vegetables to grow as a beginner. Want to learn more about Wanda and her work with Deep South Homestead? Click here now! Episode also available on Apple Podcast: http://apple.co/30PvU9C

Today, we are rejoined by Dr. Bill McGraw, a recurring guest deeply familiar with over a dozen alternative healing therapies. Testing these modalities of healing on countless patients with great success, Dr. McGraw is dedicated to overcoming chronic diseases using holistic therapeutic methods. In this episode, we discuss a fascinating sect of alternative medicine: electromagnetic frequencies (EMF). EMFs are all around us – but can they harm the human body? If so, how does heavy metal toxicity play a role in the effects of EMFs? Dr. McGraw sits down to explain… Jump in now to find out: When and why negative electromagnetic fields were introduced. How to eliminate toxic heavy metals from the body. The various sources of electromagnetic radiation. To learn more about EMFs and Dr. McGraw's work, click here now! Episode also available on Apple Podcast: http://apple.co/30PvU9C

Today, we connect with Mark Lakeman, the founder of City Repair, a non-profit placemaking movement and organization. He is also the principal and design director of Communitecture, a community architecture and planning firm. Recognized as a leader in the development of sustainable public places, Mark is on a mission to provide a beneficial vision for human and ecological communities. Mark has professional training in architecture and permaculture. Drawing from this background, he is what's called a "design activist". How do his projects impact the development landscape of the United States? He sits down to explain… In this episode, we go over: Why the history of the U.S. prioritizes real estate development over cultural development. Why people's relationships affect how local problems are solved. The importance of community space in a cultural setting. Want to learn more about Mark and his work? Click here now! Episode also available on Apple Podcast: http://apple.co/30PvU9C