Finding Genius Podcast

For over 30 years, Ted Schroeder has been involved in the sales, marketing, and development of antibiotics, and he currently serves as the CEO of Nabriva Therapeutics. He joins the podcast today to discuss the current work being done at Nabriva, which involves the development of a new class of IV antibiotics for the treatment of community-acquired pneumonia in adults—the first of its kind in the US in over two decades. The second product Nabriva is working on has been around for nearly four decades but has never been available in the US, and it's been shown to be effective in tackling complicated urinary tract infections and multidrug-resistant strains of bacteria. These antibiotics could limit or altogether eliminate the need for hospital stays for many people. To learn more about the work being done, tune in. You'll discover the details of all this and more, including: What makes gram negative bacterial infections so much more difficult to treat than gram-positive bacterial infections How strong the clinical-based evidence is for the effectiveness of these antibiotics What's on the horizon in the near future for Nabriva Therapeutics, pharmacology, and anti-infective agents For more information, visit https://www.nabriva.com/.

Ronald C. McGlennen, M.D., President & Medical Director of Access Genetics, delivers an interesting overview of oral issues, discussing the microbiome and bacteria. In addition to his work with Access Genetics, Dr. McGlennen is also the Associate Professor of Pathology at the University of Minnesota Medical School. Dr. McGlennen is board certified in Anatomic and Clinical Pathology, and by the American Board of Medical Genetics with a Specialty in Clinical Molecular Genetics as well. The internationally-recognized expert in Molecular Biology and Genetics discusses his thoughts on the oral microbiome, periodontal disease, and conditions of the mouth. Dr. McGlennen states that the microbiome has earned its place as an organ in our bodies and must be recognized for its role that is central to good health. Changes in the gut flora can provide answers to intestinal health, and the microbiome truly holds many answers to medical issues. In regard to bad bacteria, he states, much of it comes from our environment—intimate contact, foods, surfaces, etc. He explains how, over time, due to age and lack of exercise etc., we move into a state of dysbiosis, which is essentially a microbial imbalance on or inside the body—such as an impaired microbiota. Dr. McGlennen discusses the ways in which our microbiome can be affected, and he delves into an overview of periodontal disease and its causes. He discusses disease markers and pathogens, and the indicators of disease. The doctor provides intricate detailed information on gum disease, plaque build up, bad bacteria in the mouth, other specific detrimental issues of the mouth, and mouth bacteria treatment. He discusses the eleven bacteria that make up the 'quantitative DNA analysis' and how they can utilize this information to understand cumulative bacterial load, and to grasp how to best provide treatments and therapies. Dr. McGlennen has published over 70 important scientific articles and book chapters and he is the distinguished editor of five journals. In this podcast: What is a quantitative DNA analysis, and how can it help you on your path to better health? What are the effects of microbial imbalance? How does a body connect with bacteria?

Wynand De Beer, independent researcher and philosopher, specializing in Hellenic philosophy and Patristic theology, discusses philosophy; socio-political discourse; and metaphysics, the specific branch of philosophy that pertains to the nature of existence, being, and the world. De Beer is a member of the Russian Orthodox Church and he has written numerous articles for Orthodox publications and various websites, penned under his Orthodox name, Vladimir de Beer. He is the author of From Logos to Bios: Evolutionary Theory in Light of Plato, Aristotle, and Neoplatonism. De Beer discusses his thoughts on philosophical, socio-political, theological, and metaphysical issues. He explains that much of the mindset regarding issues of this nature has been lost due to rationalism, secular humanism, and materialism. He talks about the important works of others who have come before him, such as Albert Camus, the French Algerian philosopher, author, and journalist. De Beer talks in detail about some of the areas of his latest book, analyzing big issues from various chapters, from well being and love, to good vs evil, to consciousness, and the three manifestations of consciousness. Digging deeper, De Beer provides an analysis of gender, as it relates to our current and historical interpretations. He states that the traditional understanding of man and woman, male and female, must function as polar opposites in order to constitute the reality that we live in. He provides an interesting account of the views on feminism, and the militant forms of feminism, and male chauvinism… all of which must be rejected as wrong, as they present an imbalanced view. There is no subordination or domination he states. De Beer explains that the views and function of gender and sexuality, etc. are often taken to the extreme, perhaps as a form of rebellion, but ultimately too extreme. De Beer continues, discussing the details of other areas of his book, including a salient discussion on modern liberalism. He discusses his views on the immortality of the soul, referencing early Greek mythology from significant voices such as Plato. The influential author and philosopher provides further details on his thoughts on politics and conflict. He discusses his next book, currently titled, Origins, and expounds upon some of the topics he will touch upon in the upcoming work. In this podcast: An overview of metaphysics What would Plato do: various thoughts on the great philosopher Man vs Woman: the gender divide

Snoring is so common these days that some people either think it's normal or just learn to live with it, but many encounter all kinds of problems as a result of snoring, including relationships and serious health problems. When Erin Elliott began asking her dental patients how they sleep at night and whether or not they snore, she was given a lot of strange looks. That was 10 years ago when the connection between dental signs and symptoms weren't really considered to have anything to do with sleep or snoring. Today, many more dentists are acknowledging how they are intertwined and integrating this understanding into their practice. Erin Elliott is a dentist who is so well known for this that many of her patients are referred to her for snoring problems by physicians or existing patients. On today's episode, she discusses the varying causes and effects of snoring and how essential it is to identify the cause before implementing a snoring treatment, what kinds of dental signs and symptoms indicate the presence of a sleep or breathing problem, what's happening physiologically when someone snores, and so much more. By tuning in, you will discover: How and why snoring can lead to tooth decay and poor gum health Why losing weight could significantly improve snoring for one person, and not make a difference for another Surgical, therapeutic, and lifestyle changes which could help reduce snoring Learn more by tuning in and emailing your questions to erinelliottdds@gmail.com.

Richard Gallo, MD, PhD, a leading expert in human immunology, skin biology, and the microbiome, delivers an interesting overview of skin issues, the microbiome, antimicrobial peptides, skin microbiome acne, and so much more. Gallo earned his PhD from Harvard and has pursued a life in the sciences. Gallo talks about his background and how he came to be so interested in dermatology and immunology, and as he states, the big question for Gallo was, how does a host protect itself? He provides an overview of 'resistance' and how it differs, discussing how humans and plants, etc. can be affected by a microbe. Gallo comments that the skin is the first layer separating the inside… from the outside, and that's a pretty important job. What do microbes do to benefit us, speaking of those microbes that our skin tolerates? Gallo's current research and discovery revolves around this question. Gallo states that microbes can become trapped within the skin's pores, and once they are they are nurtured, kept in check by the immune system so they don't become an infection. Gallo discusses the broad range that exists in the cells of the microbial community. Gallo provides an overview of the microbial community and he explains what different genes are doing at the bacterial level. Continuing, Gallo talks about the kinds of inflammation that exist and how improvement of the microbiome can permit the human environment to correct and flourish. The immunology expert describes an ideal scenario of future medical approaches to combatting certain diseases. And he discusses some of the new issues and discoveries that show great promise, and how the skin, its microbes, and cells are all important to the understanding of how to treat disease. In this podcast: What can we learn from the microbiome? How does the skin react to microbes? The future of disease treatment

This podcast discusses exciting innovations in neutron production: How Phoenix generates neutrons with a thousand times less nuclear material than a reactor and includes the safety of an "off-switch." Why this technology is essential to the medical, air travel, and aerospace fields. How in addition to radioisotopes in medicine like the molybdenum 99 production, Phoenix can produce neutrons with tremendous flexibility key to industrial needs. What else Shine Medical plans to make, including isotopes with therapeutic potential for diseases like cancer. What else Phoenix is working on including an electronic machine to replace the difficult-to-handle isotope Californium 252. Even Sengbusch, PhD, MBA, and president of Phoenix, discusses the history of Shine Medical and Phoenix and how their work to produce neutrons through new technology leaves the danger and limitations of nuclear reactors far behind. Greg Piefer, founder and CEO of Shine Medical was unable to join the conversation because of travel issues, but Dr. Sengbusch discusses both companies and what they accomplish. Shine Medical spun from Phoenix in 2010 to focus specifically on radioisotopes in medicine. Phoenix produces neutron generators that Shine then uses for isotopes useful in medical technology imaging procedures. Phoenix focuses on molybdenum 99 production, which has been the workhorse in nuclear medicine. Currently only two places worldwide manufacture molybdenum 99, and Phoenix will soon be able to make this isotope without a nuclear reactor. When it decays, Moly 99 emits detectable gamma rays that work as markers for imaging techniques. For example, it can attach to heart-specific glucose and then provide organ information through imaging. It can also attach to cancer cells and give a clear image for cancer detection. For more information, see https://phoenixwi.com/ and https://shinemed.com/.

When you listen, you'll learn about these innovations and more: How genome editing in plants can lead to soybean oil that replaces environmentally-problematic oils like palm oil or coco butter. How Dr. Voytas is creating wheat with higher dietary fiber and more healthful benefits. Why gene editing can produce crops immune to pathogens and insects. How gene editing can increase food supply across the globe. In this podcast, Dr. Daniel Voytas, McKnight Presidential Endowed Professor, Director of the Center for Precision Plant Genomics at the University of Minnesota, and founder of Clayxt, shares these and other exciting advances in genome editing in plants. Dr. Voytas' work with the Center for Precision Plant Genomics centers on improving genome editing in plants through precise editing, substitution, and mutation techniques. The center's goal is to create plants that can withstand challenges like drought and insect predation while maintaining more healthful components. At the university, most of this work involves model plants that work well for experimentation. About ten years ago, Dr. Voytas started the company Calyxt, which transfers that technology into developing new food crops like soybeans with altered genes that offer various benefits. For example, gene editing allowed them to inactivate the gene that converts the oil in the soybean seeds from monounsaturated to polyunsaturated fat. The company produced their first gene-edited product for sale with this monounsaturated soybean oil that has a much longer life for deep frying. For more information on how to contact Dr. Voytas, see https://cbs.umn.edu/contacts/daniel-voytas-phd.

Mark A. Cruz, D.D.S, a pioneer in the dental industry, shares information on modern dentistry, snoring causes and effect, snoring treatment, rhinitis, and stuffy noses. Dr. Cruz is a seasoned, trusted family dentist who approaches all dental issues with a macro lens, considering his patients' overall health, instead of simply treating problems as they occur. Dr. Cruz graduated from the UCLA School of Dentistry. A few of his outstanding accomplishments include serving on the National Institute of Health/National Institute of Dental & Craniofacial Research Grant Review Committee in Washington D.C., and being an integral part of the editorial board for the Journal of Evidence Based Dental Practice. Dr. Cruz is motivated by learning and is continually expanding his knowledge to better serve his patients. Dr. Cruz discusses teaching and orthodontics, and the importance of nasal breathing. He provides detail on why we as humans can and do breathe nasally and orally as well. He explains oral breathing, the exchanging of gas, and the processes our bodies go through. He provides an overview of nasal breathing and discusses the inflammatory response that the body exhibits when nasal breathing is cut off or compromised. Expanding on this discussion he discusses the importance of teaching kids the proper ways to breathe and blow their noses, etc. While mucus has a purpose, we do not want it to obstruct nasal breathing to the point that we are always breathing through the mouth. He discusses practical methods to increase nasal breathing, such as the neti pot, etc. for rinsing debris or excess mucus from the nasal cavity. Continuing, Dr. Cruz provides information on studies that have observed breathing. Breathing rate was documented over decades, and surprisingly we have, overall, increased breathing rates. And unfortunately, this increase may be a key link to increases in inflammatory diseases. The doctor discusses exercises and specifically touches on facial exercises, which could decrease sagging, and other detrimental effects of aging. And Dr. Cruz provides detailed information on snoring and breathing issues, and how medicine practitioners are now paying more attention to airway issues perhaps than before. In this podcast: What causes snoring? What happens when nasal breathing is diminished? How can we improve airway problems?

"The second you think you know everything, you realize there's a lot you don't know," says Marc Bekoff, who has spent his entire career studying animal behavior and biology and playing an integral role in animal rights organizations. As Professor Emeritus of Ecology and Evolutionary Biology at the University of Colorado, Boulder and Fellow of the Animal Behavior Society, Dr. Bekoff values productive conversation with people who bring different opinions to the table, and advocates for the importance of understanding the complexity of all other species on planet Earth. He joins the podcast today to discuss the surprising similarities and differences between and within different species, the role domestic dogs play in our lives and vice versa, how personality variation contributes to the formation and maintenance of groups of animals, and so much more. Tune in to learn: How common myths about domestic dogs are perpetuated in society What he's learned through long-term studies on coyotes in Grand Teton National Park Observations that demonstrate fair behavior within a species, whether in terms of playing, eating, or grooming (and how "cheaters" in the system tend to do in the long run) Learn more by visiting marcbekoff.com.

Out of the 100 million people in the U.S. who snore, more than half of them have sleep apnea, a condition which causes the cessation of breathing up to hundreds of times per night during sleep. In addition, snoring itself is a gateway to sleep apnea, meaning that most people who snore regularly are at risk of developing sleep apnea. Dr. Jay Khorsandi is a general dentist and snoring and sleep expert who joins the show today to discuss the causes and effects of snoring, and how age and weight contribute to sleep apnea and poor overall sleep health. He also discusses his approach to diagnosing and formulating individualized plans for the treatment of different snoring and sleep issues. This approach begins in the patient's home rather than the clinical environment of a sleep lab. He explains why this is beneficial and what type of information he is able to gather. Tune in to discover: Why people tend to dream more when they breathe better during sleep How a laser can be used to treat snoring and breathing problems in a non-invasive, quick, and effective way How snoring progresses through stages to ultimately become sleep apnea