Healthcare Unfiltered

Continuing the ketogenic discussion, Chadi hosts Nick Norwitz (@nicknorwitz), PhD, Harvard Medical School, and welcomes back Dave Feldman (@DaveKeto), senior software engineer and entrepreneur, to discuss their recently authored paper “Elevated LDL Cholesterol with a Carbohydrate-Restricted Diet: Evidence for a ‘Lean Mass Hyper-Responder’ Phenotype.” The trio discuss the inspiration for the paper, the methodology and survey questions, results and take-home messages, and the broad range of reactions the paper evoked.Read the authors’ discussed research paper.https://academic.oup.com/cdn/article/6/1/nzab144/6446805Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Sanam Loghavi (@sanamloghavi), MD, hematopathologist and molecular pathologist at the University of Texas MD Anderson Center, provides a clear picture of pathology as a specialty in this informative episode. Dr. Loghavi argues that medical school curriculum falls short in including pathology as a legitimate specialty for students to pursue, credits and discredits the preconceived notions about what pathology is all about, shares what differentiates good pathologists and exceptional pathologists, breaks down the subspecialties within pathology, comments on the future of artificial intelligence in pathology, and a whole lot more.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi hosts a very renowned, high profile guest – one of the leading vaccine experts in the world and the man co-credited with developing the rotavirus vaccine: Paul Offit (@DrPaulOffit), MD, Director of the Vaccine Education Center and Professor of Pediatrics, Children’s Hospital of Philadelphia. Dr. Offit tackles the hard-hitting questions on everyone’s minds: whether public health policy decisions should be made based on randomized controlled trials during a pandemic, what went into the FDA’s decision to postpone vaccine approval for young children, whether vaccine mandates are moral and justifiable for children, what is the basis behind a third booster dose for adults, and a whole lot more.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Tara Haella (@tarahaelle), independent science/health journalist, joins the show to discuss her reporting on vaccine hesitancy long before the pandemic (the “trenches of the mommy wars”), how this previous work aligns with today’s COVID vaccine hesitancy, and how cognitive bias plays a substantial part in our individual feelings toward vaccines. Tara explains the longstanding history of vaccine hesitancy, how she came to initially distrust the CDC, how vaccine hesitancy was likely exacerbated by political motives when COVID hit, how much blame public health messaging may have toward COVID vaccine hesitancy, and a host of other interesting, controversial topics.View Tara’s personal website.https://tarahaelle.net/Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chris Arnade (@Chris_arnade), long-time writer and author of “Dignity: Seeking Respect in Back Row America,” joins the show to discuss his recent experience walking America and how his views on politics and the COVID-19 response have changed as a result. Chris shares his unique upbringing and professional background, ways in which he satisfied his early interest in long walks and what he made of these walks, and how this interest developed into touring the U.S. and photographing the people he encountered. Chadi and Chris discuss the “real America” and break down the “rows” of people in the country, how leaders have failed the lower class when it comes to COVID messaging, and many other interesting topics.Check out “Dignity: Seeking Respect in Back Row America.”https://www.amazon.com/Dignity-Seeking-Respect-Back-America/dp/0525534733Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi hosts a truly inspiring pediatrician, author, philanthropist, humanitarian, and self-described “healer”: Noha Baz. Dr. Baz opens up about her unique childhood beginning in France and moving to Lebanon, some harrowing stories about young patients being refused care because of lack of money to pay for treatment, her eventual founding of “Les Petits Soleils” in 1997 to provide medical care for children living in Lebanon not benefiting from health coverage, maintaining her focus despite political turmoil in Lebanon, her deep love for food and how she incorporates it into her work, and a whole lot more.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi welcomes two experienced medical writers, Marielle Fares and Tom Lang, to explain what “medical writing” entails and who the intended audience is, the difference between regulatory and medical education writing as well as patient education and scientific publications, how medical projects come in and what types of instructions and materials medical writers are given, the ins-and-outs of the revision process, what it means when medical writers are listed in the acknowledgments of published clinical research, and many more points of interest.View Tom Lang’s instructive publications on medical writing.https://www.amazon.com/dp/1934465143/ref=cm_sw_r_em_api_glc_i_C5VAJPX36K9384Z844CYhttps://www.amazon.com/dp/1930513690/ref=cm_sw_r_em_api_glc_i_7ZKVGTQ9G44AJ9KV2RA1Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Naveen Pemmaraju (@doctorpemm), MD, department of leukemia, University of Texas MD Anderson Center, joins the show to discuss how researchers approach the investigation of rare diseases. Chadi and Dr. Pemmaraju break down the latter’s distinguished work in blastic plasmacytoid dendritic cell neoplasm (BPDCN)—a rare, aggressive hematologic cancer—as well as other rare and orphan diseases. Context for the rare and orphan disease drug development pathway, granular classification for malignancies (particularly in hematology), and so much more is provided in this thorough, fascinating dialogue.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi welcomes back Bishal Gyawali (@oncology_bg), MD, PhD, Queen’s University Cancer Research Institute (Canada), to the show to discuss the history of the FDA’s accelerated approval regulatory pathway, how it is sometimes abused, how low-level surrogate endpoints are being used for approval, what happens (and what should happen) when confirmatory trials do not confirm clinical benefit for drugs approved through this pathway, how conflicts of interest may impact some regulatory decisions, and so much more. Dr. Gyawali raises some thought-provoking questions and critical points in this deep, nuanced discussion.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Continuing his ASH Annual Meeting coverage, Chadi invites Matt Maurer (@MaurerStats), MS, principal biostatistician, Mayo Clinic, and Alan Skarbnik (@ASkarbnik), MD, director of the lymphoma and CLL program, Novant Health (Charlotte, NC), to review the three prominent CAR-T studies in relapsed/refractory DLBCL presented at the meeting. Why were the results divergent and what does this mean for CAR-T’s utility in this setting? The trio break down the ins-and-outs of the trials – both from a statistician and practitioner point of view.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA