This Week in Virology

Ori joins TWiV for an update on the SARS-CoV-2 pandemic, including scary modeling, clinical trials for antivirals and vaccines, asymptomatic transmission, and much more inspired by listener email. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Guest: Ori Lieberman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Scary modeling (Imperial College London) Avigan vs SARS-CoV-2 (NHK) SARS-CoV-2 mRNA vaccine (Clinical Trials) SARS-CoV-2 stability (NEJM) Pediatric COVID-19 (one, two) SARS-CoV-2 asymptomatic infection (one, two) CDC data on SARS-CoV-2 CFR (MMWR) Hydroxycholorquine trial for COVID-19 (Mediterranee-infection) Macaque SARS-CoV-2 immunity (bioRxiv) Image by Michele Banks Letters read on TWiV 591 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Epidemiologist Stephen Morse joins Vincent to discuss epidemiology of SARS-CoV-2 and preparedness for the COVID-19 pandemic. Hosts: Vincent Racaniello Guest: Stephen Morse Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Ori Lieberman joins Vincent to discuss COVID-19, the disease caused by SARS-CoV-2, gleaned from his experience during clinical rotations in medical school. Hosts: Vincent Racaniello Guest: Ori Lieberman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Ralph Baric joins TWiV to dissect the coronavirus pandemic caused by SARS-CoV-2, including discussion on community spread, asymptomatic infections, origin of the virus, transmission, vaccine development, and much more. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Ralph Baric Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Aerosol and surface stability of SARS-CoV-2 (medRxiv) Clinical course and risk factors for COVID-19 (Lancet, pdf) Face mask use during SARS-CoV outbreak (EID) COVID-19 and Italy (Lancet) Letters read on TWiV 591 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV trio continues in-depth coverage of COVID-19 and SARS-CoV-2, including discussion on genome mutation and circulating lineages, handwashing, facemasks, cruise ship outbreaks, the South Korean situation, and much more. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Stanley Perlman answers CoV questions (Boston Globe) Fist bump (Am J Infect Control) Joint WHO-China report (pdf) Second coronavirus (LA Times) Response to second coronavirus (virological.org) COVID-19 animal models (STAT) Clinical predictors of COVID-19 mortality (Inten Care Med) CoV by the numbers (NY Times) Contamination of bar soaps (Microbios) SARS-CoV-2 vaccine timeline (NPR) How new vaccines are developed (GSK) SARS among critical care nurses (Emerg Inf Dis) How churches prevent SARS-CoV-2 spread (NPR) Image credit Letters read on TWiV 590 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Infectious disease physician Daniel Griffin and virologist Valeria Cagno join Vincent to provide updates on the situation with SARS-CoV-2 and COVID-19 in New York and Italy. Host: Vincent Racaniello Guests: Daniel Griffin and Valeria Cagno Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent and Rich update the current situation with COVID-19 and SARS-CoV-2, including fatality ratios, virus spreading outside of China, immunity to infection, vaccines, antivirals and much more. Hosts: Vincent Racaniello and Rich Condit Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode WHO CoV sitreps How to Prepare for the Coronavirus (NY Times) Multiple shedding routes of SARS-CoV-2 (Emerg Microbes Inf) Cruise ship a/c could promote virus spread (Purdue news) Image credit Letters read on TWiV 589 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV team returns this week to SARS-CoV-2019 coverage to review the latest epi curves, the fatality rate, furin cleavage site and receptor binding domain in the spike glycoprotein, related CoV recovered from pangolins, evidence that the virus did not escape from a laboratory, and many more questions sent in by listeners. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode WHO CoV sitreps Epidemiology of COVID-19 (China CDC) COVID-19 incubation period (J Med Virol) China clinical trials for COVID-19 (Nature) Furin cleavage site in SARS-CoV-2 spike (virology blog) Proximal origin of SARS-CoV-2 (Virological) Pangolin photos (Nat Geo) Letters read on TWiV 588 Timestamps by Jolene. Thanks! Weekly Science Picks Kathy - The deep sea Rich - World's oldest message in a bottle Dickson - Coronavirus: A visual guide Vincent - Recent NSABB meeting Videocasts Day 1 Day 2 Listener Picks Stephen - This podcast will kill you Neva - China's surveillance Sophia - WHO online courses Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent and Rich return to the University of Texas Medical Branch at Galveston to speak with Dennis Bente, Shannan Rossi, Nikos Vasilakis, and Scott Weaver about their work on viruses transmitted by mosquitoes and ticks. Hosts: Vincent Racaniello and Rich Condit Guests: Dennis Bente, Shannan Rossi, Nikos Vasilakis, and Scott Weaver Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Measles virus vectored chikungunya vaccine (J Inf Dis) World Reference Center for Emerging Viruses and Arboviruses Insect-specific alphavirus vaccine vector (Nat Med) Legacy of arbovirus hunters (Viruses) Electron microscopy for novel arboviruses (Viruses) Sylvatic dengue (Am J Trop Med Hyg) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

In this week's coverage of the coronavirus epidemic, the TWiV team discusses the fatality rate, China's initial reaction to the outbreak, conspiracy theories, how long the virus remains infectious on surfaces, and evidence for virus in the intestinal tract. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Download TWiV 586 (72 MB .mp3, 119 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode China reacted too slowly to epidemic (NY Times) Wuhan rounds up infected (NY Times) 2019-nCoV asymptomatic transmission report flawed (Science) Mucus reduces effectiveness of alcohol gels (mSphere) SARS-CoV in feces (NEJM, Gastroenterology) Inadequate plumbing and spread of SARS-CoV (WHO) Persistence of virus on surfaces (one, two, three, four) Letters read on TWiV 586 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Mutation, Adaptation, and Virus Genomes Alan - The Comet Rich - Finding Your Roots: Science Pioneers Dickson - Let's Fill Our Cities With Taller, Wooden Buildings Vincent - Twenty-first century plague by Thomas Abraham Listener Pick Mark - Tracking CoV infections Sophia - Legislative approaches to immunization Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv