This Week in Virology

Raul Rabadan joins TWiV to explain the use of computational biology to demonstrate how recombination and mutation led to emergence of SARS-CoV-2. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guest: Raul Rabadan Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Rabadan Laboratory Understanding Coronavirus (Amazon) Topological Data Analysis for Genomics and Evolution (Amazon) Recombination and mutation shaped SARS-CoV-2 (bioRxiv) Bat CoV with cleavage site insertion (Curr Biol) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

From the Nipah Virus International Conference in Singapore, Vincent speaks with meeting participants about the history of the first Nipah virus outbreak, lessons learned from Hendra virus, surveillance of bats for viruses, and the development of a vaccine. Hosts: Vincent Racaniello Guests: John Mackenzie, Jon Epstein, Eun-Chung Park, and Linfa Wang Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical update on COVID-19, then we review TETRIS by Paterson NJ, modeling the effects of intervention in the US on cases and deaths, mixing PCR and serology data, and much more, including listener email. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Playing tennis safely (USTA) Scientists denounce end to CoV grant (NY Times) ASMBMB denounces end to CoV grant (pdf) For TETRIS, turn to Paterson NJ (NY Times) NJ Dept of Health (image credit) Differential effects of intervention timing (medRxiv and NY Times) Texas to stop combining test results (Statesman) How could CDC make that mistake? (Atlantic) The Pandemic and Information Network (Columbia Journ Rev) Helmet and tent (Science) New song, old melody (Cell Host Microbe) Letters read on TWiV 617 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent, Kathy and Rich discuss COVID-19 research paper overload, Moderna's mRNA vaccine Phase I results, increase of ACE2 RNA by cigarette smoke, and answer listener questions. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Drowning in COVID-19 papers (Science) CORD-19 2019 NCRC AI powered literature review SciSight Graphical guide to CoV vaccines (Nature) Moderna Phase I results Liposomes and lipid nanoparticles (Exelead) Cigarette smoke increases ACE2 (Dev Cell) Letters read on TWiV 616 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent speaks with Peter Daszak, President of EcoHealth Alliance, a global nonprofit organization dedicated to protecting wildlife and public health from the emergence of disease. Hosts: Vincent Racaniello Guests: Peter Daszak Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. 20% off The Invisible ABCs for TWiV listeners! Use promo code: ABC20 at checkout. Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical update on COVID-19, then we review results showing requirement for the furin site in the SARS-CoV-2 spike for replication, US state vaccine exemptions, concerns with a rapid diagnostic test, and answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Triple therapy for COVID-19 (Lancet) Virology podcast goes viral (Thalia Gigerenzer) Paul Stays Home (pdf) Multibasic cleavage site essential for SARS-CoV-2 infection (Mol Cell) Mumbai engulfed by CoV (NY Times) All must be vaccinated (Stat) FDA concerns with Abbott test (FDA) How US lost 6 weeks (BBC) Image credit Letters read on TWiV 614 20% off The Invisible ABCs for TWiV listeners! Use promo code: ABC20 at checkout. Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent, Kathy and Rich explain the Jenner Institute's SARS-CoV-2 vaccine, the NIH decision to stop the Remdesivir study, and answer listener questions. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 brings out dark side of science (Mother Jones, Wired) Jenner Institute COVID-19 vaccine (BioSpace) Recombineering (Nucleic Acids Res) Vaccines lecture (YouTube) ChAdOx1 MERS vaccines protects NHP (Lancet Inf Dis) Chimpanzee adenovirus vector (PLoS One) Ad-MERS vaccine protects monkeys (NIH) Rapid COVID-19 vaccine development (Science) Strategic approach to COVID-19 vaccines (Science) NIH decision to stop remdesivir study (Stat) 80,000 flu deaths this winter (Stat) Science and singing (YouTube) COVID-19 at choir practice (Emerg Inf Dis) 20% off The Invisible ABCs for TWiV listeners! Use promo code: ABC20 at checkout. Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

From the Nipah Virus International Conference in Singapore, Vincent speaks with Richard Hatchett, CEO of CEPI, about its mission to stimulate and accelerate the development of vaccines against emerging infectious diseases. Hosts: Vincent Racaniello Guests: Richard Hatchett and Linfa Wang Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a weekly clinical update on COVID-19, then Michael Schmidt discusses how dentistry can be safely practiced during a pandemic, followed by answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guests: Daniel Griffin and Michael Schmidt Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode OSHA guidance for dentistry COVID0-19 challenges for dentistry (J Dent Res) COVID-19 and dentistry (Int J Env Res Pub Health) Mouthrinses for dentistry (J Clin Med) Disingenuous plandemic documentary (Big Think) Letters read on TWiV 611 Image credit Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV team summarizes serology-based tests for SARS-CoV-2, lack of effect of ACE inhibitors or ARBs on COVID-19 severity, and answers listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode FDA revises statement on antibody tests (FDA) Serology-based tests for SARS-CoV-2 (Center for Health Security) ACE inhibitors, ARBs not linked to COVID-19 severity (Mehra study, Mancia study, Reynolds study) Global COVID-19 CFR (CEBM) Debunking transmission mutation: TWiEVO 55 Letters read on TWiV 610 Image credit Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv