This Week in Virology

Daniel Griffin provides a clinical report on COVID-19, including a discussion of the role of vitamin D in COVID-19, Michael and Christopher explain why we have made all the wrong moves during the pandemic, evidence that the D614G amino acid change improves transmission in hamsters, and listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guests: Daniel Griffin, Michael B. Yaffe, and Christopher D. Barrett Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Regeneron CoV-2 mAb cocktail results (Regeneron) Vitamin D and COVID-19 (Lancet Diabet Endocrin) J&S Ad26 SARS-CoV-2 vaccine phase 1/2a results (medRxiv) All the wrong moves (Science Signaling) Trump main drive of CoV misinformation (NYTimes) Surgisphere scandal (The Scientist) SARS-CoV-2 D614G earlier transmission in vivo (bioRxiv) Das Coronavirus bullet points Letters read on TWiV Timestamps by Jolene. Thanks! Weekly Science Picks Dickson - Why we should all wear masks Brianne - Milestones in Vaccines Rich - Wallpaper/fabric designs by David Goodsell Vincent - Das Coronavirus bullet points and a new t-shirt Listener Pick Justin - COVID Alert NY App | Department of Health Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Tony Schountz joins TWiV to explain the work of his laboratory showing that deer mice can be infected with and transmit SARS-CoV-2, and how his colony of Jamaican fruit bats is being used to understand their response to virus infections. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Guest: Tony Schountz Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-CoV-2 infection of deer mice (bioRxiv) Infection of Jamaican fruit bats with MERS-CoV (Sci Rep) Immunological control of virus infections in bats (Front Immunol) Transmission of bat influenza viruses in bats (Nat Micro) Letters read on TWiV 668 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Virus Masks Kathy – UV in the vineyards (video) Rich - Great White Shark Attack Vincent - Smart WiFi garage door opener Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, review of the phase I and II trials of the Russian prime-boost vaccine, a mouse model that recapitulates age-dependent severe disease, and listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Safety and immunogenicity of Russian COVID-19 vaccine (Lancet) 'Questionable' data in Russian vaccine results (Nature) Mouse model for SARS-CoV-2 ALI and mortality (Cell) Letters read on TWiV 667 Letters to Humans Timestamps by Jolene. Thanks! Weekly Science Picks Dickson - Rewilding Europe Alan - How to Do Nothing by Jenny Odell Rich - Gene drive engineered mosquitoes Vincent - TWiEVO 60 with 12 guests! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

David Brenner joins TWiV to explain how far-UVC lights could provide protection from SARS-CoV-2 and other airborne viruses in public places, solutions to face mask fogging, transmission during airplane flights, and listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Guest: David Brenner Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Far-UVC light inactivates viruses (paper one and two) Tips to avoid mask fogging (YouTube, article one and two) Funding for virus hunting Jonna Mazet interview (YouTube) Pandemic fake news (NY Times) Airplane SARS-CoV-2 infections (summary, article one, two, three) COVID-19: Wrong moves in wrong places (Science) Das coronavirus bullet points SARS-CoV-2 was not made in a lab (YouTube) Letters read on TWiV 666 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, superspreading potential of SARS-CoV-2 in Hong Kong, structure of virion glycoprotein of a commmon cold coronavirus reveals changes driven by prolonged circulation in humans, and listener email. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Increased risk for COVID-19 during pregnancy (MMWR) COVID-19 and community and close contact exposures (MMWR) COVID-19 clusters in Japan (Emerg Inf Dis) Eyeglass use associated with less COVID-19 (JAMA Ophthal) Superspreading of SARS-CoV-2 in Hong Kong (Nat Med) HKU1 HE structure and evolution (Nat Comm) Das Coronavirus summaries TWiVerse Letters read on TWiV 665 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

On this mid-week edition, does it matter that SARS-CoV-2 is mutating, seasonal coronavirus immunity is short-lived, another bogus claim that the virus was produced in a laboratory (it came from Nature), and answers to listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Coronavirus is mutating (Nature) Seasonal CoV immunity is short (Nat Med) Sorry, no link to the fake science document! Letters read on TWiV 664 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, including vaccines, Alan summarizes a vaccine webinar on the most advanced US trials, a nidovirus from snapping turtles, longevity of memory B cells in recovered patients, and listener email. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Young adults with COVID-19 (JAMA) Letter from Stanford professors on Atlas (pdf) National Adult and Influenza Immunization Summit Bugger, even the snapping turtles! (PLoS One) Memory B cell longevity in COVID-19 (medRxiv) Letters read on TWiV 663 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

The authors of the textbook Principles of Virology gather to reveal new additions to the fifth edition, including a new author, study questions, and a chapter on therapeutic viruses. Host: Vincent Racaniello Guests: Jane Flint, Anna Marie Skalka, Glenn F. Rall, and Theodora Hatziioannou Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Purchase PoV 5e Volumes 1 + 2 (link) Purchase PoV 5e Volume 1 (link) Purchase PoV 5e Volume 2 (link) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Ralph Baric returns to TWiV to provide an update on the COVID-19 resurgence in the US, monoclonal antibodies, antiviral drugs, vaccines, immunity and reinfection, reopening schools, and what will happen this fall. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Guest: Ralph Baric Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Broadly neutralizing sarbecovirus mAbs (bioRxiv) Evaluation of mRNA-1273 in nonhuman primates (NEJM) Bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 (bioRxiv) Mouse-adapted SARS-CoV-2 (bioRxiv) READDI Das Coronavirus summaries in English ChAdOx1 vaccine trial halted (NY Times) Impact of high frequency screening (medRxiv) Letters read on TWiV 661 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, then we discuss decline of virus-specific bone marrow B cells within a year after influenza vaccination, the push to release SARS-CoV-2 vaccines before completion of phase 3 trials, and absence of evidence for infectious virus in aerosols. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Convalescent plasma RCT (medRxiv) Multicenter RCTs on corticosteroids for COVID-19 (JAMA) Decline of influenza B cells a year after vaccine (Science) Be ready to distribute vaccines 1 Nov (WPRI and NYTimes) EUA during COVID-19: lessons (JAMA) Not evidence for aerosol transmission (one and two) Letters read on TWiV 660 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv