This Week in Virology

TWiV 688: We put COVID-19 papers through a sieve December 2, 2020 On this episode, UK grants EUA for Pfizer vaccine, advice for CDC on who to immunize first, news from Das Coronavirus, SARS-CoV-2 protease regulates innate responses, and viral mRNAs are not an indication of viral replication. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode UK grants EUA for Pfizer vaccine (NY Times) ACIP advice on who to vaccinate first (NY Times) Das coronavirus update SARS-CoV-2 protease regulates innate response (Nature) Viral mRNAs do not indicate viral replication (Nat Comm) Addendum to SARS-CoV-2 discovery paper (Nature) 16:15 SARS-CoV-2 mRNA vaccine and GC formation (Immunity) 29:35 What scientists say about masks (NY Times) 1:29:03 Letters read on TWiV 688 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Pedromics Kathy – Global map at Mars opposition Rich – Janeway's Immunobiology Vincent – Janet Iwasa's Animation Lab Listener Pick Cheryl – BioRender.com holiday card templates Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Peter Hotez joins TWiV to discuss the COVID-19 pandemic, including why it went out of control in the US, the hijacking of public health practices by anti-science extremist groups, prospects for control, and whether we will be prepared for the next one. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Peter Hotez Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Peter Hotez on TWiP 29 and TWiV Special Wednesday, January 20, 2021 (Microbes Inf) SARS-CoV-2 RBD protein vaccine candidate (bioRxiv) Anti-science extremism in America (Microbes Inf) Low cost accessible COVID-19 vaccine (PLoS NTD) Letters read on TWiV 687 Timestamps by Jolene. Thanks! Weekly Science Picks Dickson – The World's First Energy-Positive Hotel to Open in Norway Brianne – The Food Lab: Better Home Cooking Through Science Alan – ACIP's ethical principles for COVID-19 vaccine allocation Rich – The Mandolorian Vincent – T. rex and the Crater of Doom by Walter Alvarez Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides his weekly clinical report on COVID-19, including new post-exposure guidelines from CDC, clinical trials of Remdesivir and convalescent plasma, FDA EUA for baricitinib and Regeneron's monoclonal antibody and more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode WHO Solidarity trial for Remdesivir and other drugs (medRxiv) EUA for Baricitinib (FDA) EUA for Casirivimab and Imdevimab (FDA) RCT: No benefit of convalescent plasma (NEJM) Letters read on TWiV 686 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

The TWiVers analyze efficacy of the AstraZeneca/Oxford adenovirus vectored vaccine, SARS-CoV-2 did not infect miners who became ill 8 years ago after cleaning bat guano from a cave in Yunnan Province, and induction of antigen-specific germinal center responses and production of neutralizing antibody by SARS-CoV-2 mRNA vaccine but not purified protein. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, emailBecome a patron of TWiV! Links for this episode AZD1222 vaccine efficacy (AstraZeneca) Addendum to SARS-CoV-2 discovery paper (Nature) SARS-CoV-2 mRNA vaccine and GC formation (Immunity) What scientists say about masks (NY Times) Letters read on TWiV 685 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Types of Scientists Coloring Book Kathy – South Pole video Rich – Steve Jobs by Walter Isaacson Vincent – Screenology (I interviewed Deb Sklut here) Listener Pick Mona – Ad5 vector and podcast with ImmunityBio founder Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, and Shane Crotty explains a study of antibodies, B cells and T cells in patients which suggests that immunological memory to SARS-CoV-2 might be long-lived. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guests: Daniel Griffin and Shane Crotty Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode FDA authorizes Lucira mini home testing kit (FDA) 60 day outcomes of COVID-19 patients (Annals Int Med) Immunological memory to SARS-CoV-2 infection at 6 months (bioRxiv) Letters read on TWiV 684 Timestamps by Jolene. Thanks! Weekly Science Picks Dickson – Benoit Mandlebrot's 96 birthday Brianne – #BlackinImmunoWeek Rich – GoISSWatch ISS Tracking; Spot The Station (NASA) Vincent – Microbes Rule Listener Pick Agda – Sandwalk Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

On this episode of TWiV, mRNA vaccines from Moderna and Pfizer show over 90% efficacy, prothrombotic auto-antibodies in serum of COVID-19 patients, and the whereabouts of SARS-CoV-2 in the human body. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Efficacy of Moderna and Pfizer mRNA vaccines Longer shelf life of Moderna vaccine (Moderna) Prothrombotic antibodies in COVID-19 serum (Sci Trans Med) Where is SARS-CoV-2 in the human body? (PLoS Path) Letters read on TWiV 683 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Picture a Scientist Kathy – Colors of the Moon and Word that hasn't changed Rich – NASA YouTube channel Vincent – Laura Splan science art Listener Pick Mona – Ad5 vector and podcast with ImmunityBio founder Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

From Expedition 64 of International Space Station, Flight Engineer Kate Rubins joins TWiV to discuss experiments that she is working on, including cell cultures, genome sequencing, and plant growth. Hosts: Vincent Racaniello and Rich Condit Guest: Kate Rubins Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, Kathleen Crowley explains the role of Environmental Health & Safety departments, update on SARS-CoV-2 transmission in farmed mink, and the presence of pre-existing antibodies to SARS-CoV-2 in unexposed individuals. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guests: Daniel Griffin and Kathleen A. Crowley Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Pfizer vaccine efficacy (Pfizer) Pfizer vaccine (Stat) Distribution of Pfizer vaccine (NY Times) LSTMH vaccine tracker SARS-CoV-2 humans to mink and back in Netherlands (Science) SARS-CoV-2 mink isolates in Denmark (pdf) Preexisting antibodies to SARS-CoV-2 in humans (Science) Letters read on TWiV 681 Timestamps by Jolene. Thanks! Weekly Science Picks Dickson – OSIRIS-REx | NASA Brianne – Virtual Science Museum Tours Alan – Ring Fit Adventure Rich – BUGSS Baltimore Underground Science Space Vincent – Trilobite glassworks Listener Pick Gina and Joe – COVID Fan Tutte Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Mady, Fiona, and David join TWiV to discuss patients with long-term COVID and similarities and differences with ME/CFS. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guests: Mady Hornig, Fiona Lowenstein, and David Tuller Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Body Politic Survivor Corps Long-haulers redefining COVID-19 (Ed Yong) I'm 26. Coronavirus sent me to the hospital (Fiona Lowenstein) We need to talk about what coronavirus recoveries look like (Fiona Lowenstein) COVID-19 long term disability (Mady Hornig, David Tuller) At 12, she's a COVID long-hauler (Davie Tuller) NICE rejects GET, Lightning Process, CBT as cure (virology blog) I want to scream (Occupy M.E.) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical report on COVID-19, Slovlakia's plan to test all adults for SARS-CoV-2 infection, viral variants arising in Danish mink and their potential threat to humans, why it is unethical to carry out challenge trials, Nipah virus dynamics in bats and spillovers into humans, and direct cardiac damage by spike-mediated cardiomyocyte fusion. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guests: Daniel Griffin and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Denmark will cull mink (Reuters) State Serum Institute statement in Danish Unethical to use SARS-CoV-2 human challenge studies (PNAS) Nipah virus dynamics in bats (PNAS) Spike-mediated cardiomyocyte fusion (ResearchSquare) SARS-CoV-2 infects engineered heart tissues (bioRxiv) You cannot lock up all risks groups (Das Coronavirus) Letters read on TWiV 679 Timestamps by Jolene. Thanks! Weekly Science Picks Dickson – CNN News Amy – I voted and Grace for President Alan – The Story of More by Hope Jahren Rich – OSIRIS-REx and 101955 Bennu Vincent – The Vexed Muddler Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv