This Week in Virology

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVsters explore mutations in the interferon pathway associated with severe influenza in a child, outbreaks of avian influenza in North American poultry farms, Ebolavirus infection of the eye weeks after recovery, and Ebolavirus stability on surfaces and fluids. This episode is sponsored by @ASM Conferences and ASM Microbe Links for this episode Life threatening influenza and IRF7 deficiency (Science) Whole exome sequencing (Wikipedia) Herpes encephalitis in children with Trif deficiency (TWiV 175) Avian influenza in the US (USDA, ProMedMail, CDC) Ebola eye (NEJM, NYTimes) Viral persistence (Virology lectures, pdf) Uveitis (National Eye Institute) Image credit Stability of Ebolavirus on surfaces (EID) Ignorance with Stuart Firestein (TWiV Special) Letters read on TWiV Timestamps by Jennifer. Thank you! Weekly Science Picks Alan - Winogradsky time-lapseRich - Missing link in evolution of complex cellsKathy - GrantomeDickson - National Geographic Landscape Photo of the DayVincent - PyMol and Chimera Listener Pick of the Week Mauricio - Vax!

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVumvirate discusses a whole Ebolavirus vaccine that protects primates, the finding that Ebolavirus is not undergoing rapid evolution, and a proposal to increase the pool of life science researchers by cutting money and time from grants. This episode is sponsored by ASM Microbe and ICAAC/ICC Links for this episode Possible sexual transmission of Ebolavirus (MMWR) Ebolavirus whole-virus vaccine protects primates (Science) Biologically contained Ebolaviruses (PNAS) Ebolavirus is evolving but not changing (Virology) Ebolavirus not undergoing rapid evolution (Science) Letters read on TWiV 335 Timestamps by Jennifer. Thank you! Weekly Science Picks Alan - PinboardRich - Academic medicine investment in medical researchKathy - Tissue paper stop motion animationDickson - Do peer review panels select best science proposals?Vincent - MMR and autism: Still no association Listener Pick of the Week Ramon - Autism by MMR vaccine statusMehul - Ebolavirus disease courseJustin - Molecular Biology of Bacterial Viruses by Gunther S. Stent Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVles talk about endogenous viruses in plants, sex and Ebolavirus transmission, an outbreak of canine influenza in the US, Dr. Oz, and doubling the NIH budget. This episode is sponsored by SciMed Solutions and ASM Education. Links for this episode Pinot noir and viruses (Wine Spectator) 35:00 Endogenous florendoviruses (Nat Commun) 35:30 Sex and Ebolavirus transmission (WHO, CDC, NYTimes) 54:10 Ebolavirus waiting (NYTimes) 57:35 Canine influenza outbreak (ProMed, NorthStarVets) 1:01:10 Dr. Oz under fire (NYTimes) 1:06:20 TV doctors (Brit Med J) 1:09:50 Double the NIH budget (NYTimes) 1:11:45 Image credit: Grapes and Caulimovirus Letters read on TWiV 334 6:10 Timestamps by Jennifer. Thank you! Weekly Science Picks 1:17:05 Alan - NIH RFI: How do we fix this mess?Rich - Editing embryos (PopSci, Prot Cell)Kathy - Creative class presentations (one, two, three, four)Dickson - The most tornadoesVincent - Apollo 13, 45 years later (Ars, IEEE, Farewell) Listener Pick of the Week Johnye - Rudolf and Leopold Blaschka Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Host: Vincent Racaniello Guests: Ben Fensterheim, Megan Freeman, Bobak Parang, and Meredith Rogers Vincent returns to Vanderbilt University and meets up with Ben, Megan, Bobak, and Meredith to learn about life in the Medical Scientist Training Program. Links for this episode MTGR1 and intestinal secretory lineage allocation (Faseb J) Coronaviruses induce macropinocytosis (mBio) PD-1 and respiratory virus reinfection (J Immunol) Vanderbilt MSTP on Facebook Video of this episode: view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Host: Vincent Racaniello Guests: Seth Bordenstein, James Crowe, and Mark Denison Vincent visits Vanderbilt University and meets up with Seth, Jim, and Mark to talk about their work on a virus of Wolbachia, anti-viral antibodies, and coronaviruses. Links for this episode SARS-CoV error correction (PLoS Path) 19:00 Marburg virus neutralization by a human antibody (Cell one and two) 56:35 Phage WO, Wolbachia and Drosophila (Peer J) 1:02:00 Seth's blog Symbionticism 1:31:30 Seth on Twitter Video of this episode: view at YouTube Timestamps by Jennifer. Thank you! Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiV team discusses the possible association of the respiratory pathogen enterovirus D68 with neurological disease. This episode is sponsored by SciMed Solutions and ASM Education. Links for this episode Clusters of AFP associated with enterovirus D68 (Lancet) 31:35 Novel outbreak enterovirus D68 strain (Lancet Inf Dis) 53:00 Enterovirus D68 in Norway (Euro Surveill) 1:12:00 Unknown enemy (Nature) 1:10:40 Enterovirus D68 on TWiV 302 Letters read on TWiV 331 8:00, 1:23:50 Timestamps by Jennifer. Thank you! Weekly Science Picks 1:53:50 Alan - OU0POLIO ham radio special event station (on air reports)Rich - Crane building itself (YouTube)Kathy - Vaccine heroes LEGO projectDickson - Life at the limitsVincent - Emperor of all Maladies film and Conference gender balance Listener Pick of the Week Jake - Designing useful microbes Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVers explain how a protein platform assists the hepatitis C virus RNA polymerase to begin the task of making viral genomes. Links for this episode NYAS Afterschool STEM Mentoring Program Concerns about editing the human germline (Science, Nature) Engineering the perfect baby (MIT Tech Rev) RNA recognition by HCV polymerase (Science) Kickstarting an RNA polymerase (Science) A protein platform for priming (virology blog) Apoenzyme and holoenzyme (Wikibooks) Ebolavirus will not become a respiratory pathogen (virology blog) Burkholderia pseudomallei (CDC) Letters read on TWiV 330 Timestamps by Jennifer. Thank you! Weekly Science Picks Alan - X-Flare 2.1 capturedRich - Volvo ocean race drops research buoys (YouTube)Kathy - Nature double-blind peer reviewDickson - Largest cave in the worldVincent - New program for early-career scientists Listener Pick of the Week Michael - Space Engine and Kerbal Space ProgramVarun CN - Incognito by David Eagleman Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiV team reviews identification of immune biomarkers in CFS/ME patients, and how a cell nuclease controls the innate immune response to vaccinia virus infection. Links for this episode Immune signatures in ME/CFS (Science Adv) 11:15 Systemic exertion intolerance disease (Lancet) 19:50 Cell nuclease controls anti-viral responses (Cell Host Micr) 25:10 Poxvirus decapping enzymes prevent innate responses (Cell Host Micr) 1:15:40 Caps off to poxviruses (Cell Host Micr) Drummer Mohr (YouTube) 1:24:05 Bornavirus in squirrel breeders (ProMedMail) 1:28:45 Principles of Microbial Diversity 5:30 Journal of Microbiology & Biology Education 1:24:25 Cross-stitch by Anne Marie 1:34:40 Letters read on TWiV 329 1:25:00 Timestamps by Jennifer. Thank you! Weekly Science Picks 1:35:10 Alan - NASA Solar Dynamics Observatory videoRich - Mutagenic chain reaction (Video: Genome editing with CRISPR)Kathy - Science Ambassadors ProgramDickson - Street ArtVincent - End Polio Now Listener Pick of the Week Ross - Three PhD Comics on Nature vs Science (one, two, three)Ricardo - Demographic Party Trick Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVocateurs discuss how the RNA polymerase of enteroviruses binds a component of the splicing machinery and inhibits mRNA processing. Links for this episode Viral polymerase binds Prp8 to inhibit mRNA splicing (PLoS Path) Prp8 protein of the spliceosome (RNA) Nuclear entry of poliovirus RdRp (Virol) RNA processing (TWiV 216) Measles in USA (CDC) Principles of Microbial Diversity Journal of Microbiology & Biology Education Letters read on TWiV 328 Weekly Science Picks Alan - Positively Negative (PLoS One)Rich - ISS assembly (YouTube)Kathy - Ancient treesDickson - Carolyn PorcoVincent - Tony Fauci on Ebola outbreak (YouTube) Listener Pick of the Week David - Shot by ShotJudi - The Power of Herd Immunity Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The eTWiVicators review evidence that the HIV-1 group O epidemic began with a single cross-species transmission of virus from western lowland gorillas. Links for this episode Traces of ATCV-1 associated with laboratory contamination (PNAS) ATCV-1 findings not explained by contamination (PNAS) Origin of HIV-1 group O epidemic in western lowland gorillas (PNAS) INNO-LIA Principles of Microbial Diversity Image credit: John Letters read on TWiV 327 Weekly Science Picks Alan - California bill to eliminate personal vaccine exemptionsRich - Kepler observatory (Kepler-186f)Kathy - USGS disease mapDickson - Philosphy of Microbiology by Maureen O'MalleyVincent - Nautilus Listener Pick of the Week Ken - Life in our phage world (online, book party); All about that baseNeal - Gilles van Cutsem at CROIRicardo - Flow hive Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv