Redefining Medicine

Leo Grady, PhD, AI and microbiome founder; Helen Messier, MD, PhD, molecular immunologist and longevity clinician; Lawrence Kosinski, MD, gastroenterologist and value-based care leader. They discuss how AI decodes microbiome signatures before disease. Conversations cover gut–brain links, microbial metabolites like butyrate, TMAO and cardiovascular risk, effects of diet, fiber and drugs on microbiome, and clinical uses of fecal testing.

On the next episode of Redefining Medicine, we'll be joined by an incredible panel of experts, including Jim LaValle, Sahar Swidan, and Drs. Crozier and Schwartz. Together, they will discuss the launch of the groundbreaking new A4M Fellowship and pave the way for exciting developments in 2026. This episode will provide: Insights into the vision and goals of the new A4M Fellowship. A look back at the program's achievements as it concludes in 2025. A preview of what's on the horizon for 2026 and beyond. Don't miss this opportunity to hear from thought leaders shaping the future of Longevity medicine and advancing the field in transformative ways.

In this episode of the Innovations and Clinical Implementation podcast, hosts Tom Blue and Sonia Horner discuss the future of AI-driven medicine with Dr. Don Brown, a physician entrepreneur and the former founder of LifeOmic who emerged from retirement to create Bioscope.ai. The conversation explores how Bioscope.ai functions as a revolutionary "AI Medical Colleague" by aggregating vast datasets—including whole genome sequencing, EMRs, and multi-omics—into a secure cloud repository that feeds an orchestration layer of multiple LLMs grounded in academic research. Dr. Brown details the platform's "synoptic view," an interface inspired by high-performance aircraft that visualizes 15 dimensions of health on a 3D wireframe, and introduces "Lumina," an AI persona that learns a physician's specific style to generate personalized care plans, ultimately allowing practices to offer high-value subscription models that turn static health data into a dynamic asset. For access to episode resources. https://sites.google.com/ovationlab.com/innovationsinclinicalimplement/home

In this episode of the Innovations and Clinical Implementation podcast, hosts Dr. Lexi Gonzales and Tom Blue interview Dr. Sundeep Dugar, a pharmaceutical drug hunter with nearly 40 years of experience in small molecule discovery who serves as the co-founder and Chief Scientific Officer at Blue Oak Nutraceuticals. The conversation focuses on the development of Mitocatalyst, a precision-formulated epicatechin designed to mimic the mitochondrial biogenesis normally triggered by exercise. Dr. Dugar reveals his breakthrough discovery that exercise-induced Reactive Oxygen Species (ROS) signal the mitochondria to produce a specific steroid—11-beta hydroxyprogesterone—and explains how Mitocatalyst utilizes nanomolar doses of epicatechin to molecularly mimic this steroid, distinguishing it from high-dose antioxidant protocols that paradoxically blunt these beneficial signals. The discussion uses the metaphor of building a "fireplace" (mitochondria) to burn "firewood" (nutrition), positioning the supplement as a critical intervention for aging patients or those unable to exercise. For access to episode resources: https://sites.google.com/ovationlab.com/innovationsinclinicalimplement/home

In this episode of the Innovations and Clinical Implementation podcast recorded at LongevityFest 2025, host Dr. Lexi Gonzales discusses the future of scalable healthcare with Dr. Jeff Gladd—the Chief Medical Officer at Fullscript and a practicing integrative physician—and Ben Walters, the Head of Journeys at Fullscript. The conversation centers on Fullscript's evolution into a "Whole Person Care" engine designed to alleviate administrative burden by launching **Journeys**, a new platform that aggregates fragmented patient contexts like intake forms, historical labs, and wearables into "four clean walls" to facilitate true personalization. The guests explain how embedding AI directly into the clinical workflow allows practitioners to reduce the time spent on lab interpretation and plan creation from 45 minutes to under seven minutes, effectively allowing them to "5x" their patient capacity while utilizing tools like the PROM 10 framework to objectively validate clinical outcomes. For access to episode resources: https://sites.google.com/ovationlab.com/innovationsinclinicalimplement/home

In the next episode of Redefining Medicine, we are thrilled to feature Dr. Julia Mirer as she shares her inspiring journey into the world of Longevity Medicine. Dr. Mirer began her career in pediatrics, working in Harlem, where she witnessed firsthand the challenges of fragmented healthcare systems. Departments weren't working together, and critical issues were left unaddressed. Driven by a desire to make a deeper impact, she made the bold decision to leave traditional medicine and embark on a transformative path toward healing and longevity. Join us as Dr. Mirer opens up about her experiences, her passion for holistic health, and how she is redefining medicine to create a brighter, healthier future.

Join us for the latest episode of Redefining Medicine, featuring Dr. Darshan Shah, founder of Next Health and a trailblazer in longevity medicine. Dr. Shah is on a mission to help individuals add healthy years to their lives by redefining healthspan through lifestyle medicine. In this episode, Dr. Shah shares his expertise on: The transformative power of longevity medicine in extending healthspan. How lifestyle medicine serves as the foundation for adding years to your health. Practical strategies to optimize your health and redefine aging. Dr. Shah's innovative approach combines cutting-edge science with proactive wellness, empowering individuals to take control of their health and live their best lives.

Welcome to the next episode of Redefining Medicine, where we continue to explore groundbreaking approaches to health and wellness. In this episode, we are honored to feature Dr. Kristine Burke, a trailblazer in the field of Bio-Identical Hormone Therapy and a passionate advocate for cardiovascular health. Dr. Burke shares her journey into addressing cognitive decline and how her expertise in hormone therapy has led her to uncover profound connections between cardiovascular and cognitive health. With over 12 years of clinical practice, Dr. Burke has developed a unique approach to assessing cardiovascular risks through advanced lab data, achieving remarkable results. Join us as we delve into Dr. Burke's insights on the significant impact of hormone therapy and cardiovascular health and learn how her innovative methods are redefining medicine for a healthier future.

Get ready to unlock the secrets of longevity and brain health! In our upcoming episode, renowned expert Dr. Gordon Crozier takes us deep into the fascinating world of peptides and their incredible impact on human wellness. Discover how neuroprotective peptides work as your body's natural guardians, shielding not just your brain but multiple vital organs throughout your system. Dr. Crozier breaks down the complex science of neurology and longevity in ways that will transform how you think about aging and optimal health. Whether you're a health enthusiast, medical professional, or simply curious about optimizing your wellbeing, this episode delivers game-changing knowledge that could reshape your approach to healthy aging. Don't miss this essential conversation that bridges advanced science with practical health wisdom. Your future self will thank you. Subscribe now and never miss an episode of Redefining Podcast!

Get ready for an eye-opening conversation about taking control of your health! Our next episode of Redefining Medicine features a physician who's been challenging the healthcare system for over 30 years. Dr. Erika Schwartz is the founder of Evolved Science, a world-renowned medical practice in New York City built on the recognition that bio-identical hormones are the foundation for better health. For more than 30 years, Dr. Erika has been at the forefront of advanced patient care, and she was one of the first doctors in the US to treat patients with bio-identical hormones and administer preventative IVs. Dr. Erika has authored eight best-selling books, including her recently re-released "Don't Let Your Doctor Kill You," and has written numerous articles for publications such as The New York Tomes, Wall Street Journal, Daily Mail, Vogue, Town and Country, and the New York Post.