New Books in Science

An exposé of the corruption of medicine by the pharmaceutical industry at every level, from exploiting the vulnerable destitute for drug testing, through manipulation of research data, to disease mongering and promoting drugs that do more harm than good.Authors, Professor Jon Jureidini and Dr Leemon McHenry, made critical contributions to exposing the scientific misconduct in two infamous trials of antidepressants. Ghostwritten publications of these trials were highly influential in prescriptions of paroxetine (Paxil) and citalopram (Celexa) in paediatric and adolescent depression, yet both trials (Glaxo Smith Kline's paroxetine study 329 and Forest Laboratories' citalopram study CIT-MD-18) seriously misrepresented the efficacy and safety data.The Illusion of Evidence-Based Medicine: Exposing the Crisis of Credibility in Clinical Research (Wakefield Press, 2020) provides a detailed account of these studies and argues that medicine desperately needs to re-evaluate its relationship with the pharmaceutical industry. Without a basis for independent evaluation of the results of randomised, placebo-controlled clinical trials, there can be no confidence in evidence-based medicine.Science demands rigorous, critical examination and especially severe testing of hypotheses to function properly, but this is exactly what is lacking in academic medicine. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

Alzheimer’s disease, a haunting and harrowing ailment, is one of the world’s most common causes of death. Alzheimer’s lingers for years, with patients’ outward appearance unaffected while their cognitive functions fade away. Patients lose the ability to work and live independently, to remember and recognize. There is still no proven way to treat Alzheimer’s because its causes remain unknown.Mind Thief: The Story of Alzheimer's (Columbia UP, 2021) is a comprehensive and engaging history of Alzheimer’s that demystifies efforts to understand the disease. Beginning with the discovery of “presenile dementia” in the early twentieth century, Han Yu examines over a century of research and controversy. She presents the leading hypotheses for what causes Alzheimer’s; discusses each hypothesis’s tangled origins, merits, and gaps; and details their successes and failures. Yu synthesizes a vast amount of medical literature, historical studies, and media interviews, telling the gripping stories of researchers’ struggles while situating science in its historical, social, and cultural contexts. Her chronicling of the trajectory of Alzheimer’s research deftly balances rich scientific detail with attention to the wider implications. In narrating the attempts to find a treatment, Yu also offers a critical account of research and drug development and a consideration of the philosophy of aging. Wide-ranging and accessible, Mind Thief is an important book for all readers interested in the challenge of Alzheimer’s. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

Would your dog eat you if you died? What are face mites? Why do clowns creep us out? In this illuminating collection of grisly true science stories, journalist Erika Engelhaupt, the writer of National Geographic’s highly acclaimed Gory Details blog, shares the answers to these questions and many more. Gory Details: Adventures from the Dark Side of Science (National Geographic, 2020) explores the strange and shocking realities of our minds, our bodies and our universe, taking readers on a fascinating tour through overlooked but astonishing aspects of biology, anatomy, nature and more, as well as the ways that science helps to break down taboos surrounding such conversation topics as women’s bodies.Blending humor and real science, Engelhaupt shares captivating stories and intriguing research that will alter the way readers view the world. From a peek inside the world's smallest crime scenes to a hands-on look at maggot farming, Gory Details features top-notch reporting, interviews with leading scientists and a healthy dose of wit. Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. To discuss and propose the book for an interview you can reach her at galina.limorenko@epfl.ch. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

Based on a viral article, the gripping medical mystery story of Ron Davis, a world-class Stanford geneticist who has put his career on the line to find the cure for chronic fatigue syndrome, the disease killing his son. For the past six years, Whitney Dafoe has been confined to a bedroom in the back of his parents' home, unable to walk, to eat, to speak. The sound of music causes him pain. At one point, the formerly healthy, young, freelance photographer, faced starvation as his 6'3" frame withered to 115 pounds. In desperation, Whitney and his parents went from one specialist to another, and still no answers. Then, finally, a diagnosis: the mysterious disease myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS). Whitney's story is heartbreaking, but it's also one of redemption. It reaches far beyond just one family's harrowing tale. Today, ME/CFS affects between 1 and 2.5 million Americans--and 20 million people around the world. Those afflicted largely suffer in silence because the disease is little known and much misunderstood. The question lingers still whether it even exists outside the patient's mind. Often disbelieved, they're abandoned by family and friends. They lose their jobs, and battle with insurance companies over rising medical costs as the chronic disease continues on year after year. In one way, Whitney has been lucky. He could reach out to his father, a world renowned, scientist, for answers. This book is the story of one father's desperate hunt for the insidious illness that stole his son away. The Puzzle Solver follows Ron as he unravels the molecular trail within his own son's donated blood and genome, to began to find answers. He confirms this is a biological disease and uncovers new possibilities for treatments and potentially a cure. At its heart, The Puzzle Solver: A Scientist's Desperate Hunt to Cure the Illness That Stole His Son by Tracie White and Ronald W. Davis (Hachette Books, 2021) is about more than just cutting edge research or a race to find the cure for ME/CFS--it's about the unbreakable bond between a father and his son, and the lengths to which a parent will go to save their child's life. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

Viruses are not very different from machines that process information, and thus, how the virus functions can be simulated on a computer. This ability to “imitate” the way viruses behave is particularly useful today, as we battle the impact of the coronavirus pandemic and struggle to prepare for similar events.Dr. Klaus Mainzer, Co-founder and Senior Professor at the Carl Friedrich von Weizsäcker Center of the University of Tübingen and President of European Academy of Sciences and Arts in Salzburg, explains this further in a new podcast episode, in which he talks about his book Leben als Maschine: Wie entschlüsseln wir den Corona-Kode? published by Brill. He explains how bringing together the fields of bioinformatics, machine learning, AI, and big data can help us to decipher the workings of the novel coronavirus and, perhaps, be better equipped to deal with such crises in the future. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

One of the questions I am often asked is exactly what do mathematicians do. The short answer is that they look at different mathematical structures, try to deduce their properties, and think about how they might apply to the real world. Math Without Numbers (Dutton, 2020) does a wonderful job of explaining what mathematical structures are, and does so in a fashion that even readers who are uncomfortable with the process of doing mathematics can appreciate and enjoy. There are courses in music and art appreciation, and if there ever are courses in math appreciation, this book would certainly be at or near the top of the reading list. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

Can your zip code predict when you will die? Should you space out childhood vaccines? Does talcum powder cause cancer? Why do some doctors recommend e-cigarettes while other doctors recommend you stay away from them? Health information―and misinformation―is all around us, and it can be hard to separate the two. A long history of unethical medical experiments and medical mistakes, along with a host of celebrities spewing anti-science beliefs, has left many wary of science and the scientists who say they should be trusted. How can we unravel the knots of fact and fiction to find out what we should really be concerned about, and what we can laugh off?In Viral BS: Medical Myths and Why We Fall for Them (Johns Hopkins UP, 2021), medical journalist, doctor, professor, and former CDC disease detective Seema Yasmin, driven by a need to set the record straight, dissects some of the most widely circulating medical myths and pseudoscience. Exploring how epidemics of misinformation and disinformation can spread faster than microbes, Dr. Yasmin asks why bad science is sometimes more believable and contagious than the facts. Each easy-to-read chapter covers a specific myth, whether it has endured for many years or hit the headlines more recently.Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. To discuss and propose the book for an interview you can reach her at galina.limorenko@epfl.ch. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

Imagination with a Straight JacketAlan Lightman is a writer, physicist, and social entrepreneur. He has served on the faculties of Harvard and the Massachusetts Institute of Technology (MIT) and was the first person at MIT to receive dual faculty appointments in science and in the humanities. He is the author of many books, both fiction and nonfiction, including the international best seller Einstein’s Dreams and The Diagnosis, a finalist for the National Book Award.This episode goes to both what’s epic in scope and to what’s more intimate and personal. Epic is knowledge now about how the universe began and that it will end with the sun basically engulfing the earth and then burning out. More personal is that the book explores the moral, even religious issues that scientific knowledge brings with it. Most of all, this episode explores the act of intellectual inquiry and exploration through the careers of leading scientists.Dan Hill, PhD, is the author of eight books and leads Sensory Logic, Inc. (https://www.sensorylogic.com). To check out his related “Dan Hill’s EQ Spotlight” blog, visit https://emotionswizard.com. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

On Task: How Our Brain Gets Things Done (Princeton UP, 2020) is a look at the extraordinary ways the brain turns thoughts into actions—and how this shapes our everyday lives. Why is it hard to text and drive at the same time? How do you resist eating that extra piece of cake? Why does staring at a tax form feel mentally exhausting? Why can your child expertly fix the computer and yet still forget to put on a coat? From making a cup of coffee to buying a house to changing the world around them, humans are uniquely able to execute necessary actions. How do we do it? Or in other words, how do our brains get things done? In On Task, cognitive neuroscientist David Badre presents the first authoritative introduction to the neuroscience of cognitive control—the remarkable ways that our brains devise sophisticated actions to achieve our goals. We barely notice this routine part of our lives. Yet, cognitive control, also known as executive function, is an astonishing phenomenon that has a profound impact on our well-being. Drawing on cutting-edge research, vivid clinical case studies, and examples from daily life, Badre sheds light on the evolution and inner workings of cognitive control. He examines issues from multitasking and willpower to habitual errors and bad decision making, as well as what happens as our brains develop in childhood and change as we age—and what happens when cognitive control breaks down. Ultimately, Badre shows that cognitive control affects just about everything we do. A revelatory look at how billions of neurons collectively translate abstract ideas into concrete plans, On Task offers an eye-opening investigation into the brain’s critical role in human behavior.Joseph Fridman is a researcher, science communicator, media producer, and educational organizer. He lives in Boston with two ragdoll kittens and a climate scientist.You can follow him on Twitter @joseph_fridman, or reach him at his website, https://www.josephfridman.com/. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

The fallacy sold to many of us is that the penis signals dominance and power. But this wry and penetrating book reveals that in fact nature did not shape the penis–or the human attached to it–to have the upper…hand.Phallacy looks closely at some of nature’s more remarkable examples of penises and the many lessons to learn from them. In tracing how we ended up positioning our nondescript penis as a pulsing, awe-inspiring shaft of all masculinity and human dominance, Phallacy also shows what can we do to put that penis back where it belongs.Emphasizing our human capacities for impulse control, Phallacy ultimately challenges the toxic message that the penis makes the man and the man can’t control himself. With instructive illustrations of unusual genitalia and tales of animal mating rituals that will make you particularly happy you are not a bedbug, Phallacy shows where humans fit on the continuum from fun to fatal phalli and why the human penis is an implement for intimacy, not intimidation.Emily Anthes is a science journalist and author. Her books include Frankenstein’s Cat: Cuddling Up to Biotech’s Brave New Beasts and The Great Indoors: The Surprising Science of How Buildings Shape Our Behavior, Health, and Happiness. Read more about her work at emilyanthes.com or follow her on Twitter at @emilyanthes. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science