The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Mentioned books
152 snips
Sep 14, 2025 • 16min
BONUS: How To Reverse Testosterone Decline After 40 (Biohacking Tips) : 1328
Many believe that declining testosterone is just a part of aging, but that’s a myth. The podcast reveals how lifestyle changes can naturally boost testosterone levels, even without medication. It dives into the importance of diet, sleep, and light exposure in hormone health. Discover which underrated boosters can enhance your well-being and energy. Practical tips for reversing testosterone decline are shared, challenging the narrative around aging and revealing empowering strategies for men over 40.
71 snips
Sep 12, 2025 • 31min
Eat THESE Anti-Aging Mushrooms to Live Longer (Paul Stamets) : 1327
Paul Stamets, a renowned mycologist and advocate for mushrooms as medicine, joins Julian Mitchell, a sports physiotherapist turned mushroom entrepreneur. They dive into how medicinal mushrooms like lion's mane can enhance neurogenesis, memory, and immune health. The duo reveals how oyster mushrooms combat flu viruses and chronic inflammation. They also discuss the ecological importance of fungi in saving pollinators and restoring soil health, emphasizing the potential of mushrooms as powerful biohacking tools for longevity and environmental sustainability.
45 snips
Sep 11, 2025 • 1h 4min
MIT Neuroscientist: The Ultimate Nootropic For Memory : 1326
Tony Nader, a renowned neuroscientist and physician from MIT and Harvard, discusses how Transcendental Meditation serves as a powerful nootropic for memory and brain optimization. He reveals how TM improves clarity, enhances neuroplasticity, and even reduces biological age. Nader explains the unique brainwave states induced by TM and how it boosts blood flow to the prefrontal cortex, benefiting creativity and decision-making. Listeners will discover how to harness these insights to unlock their mental potential and promote longevity.
38 snips
Sep 9, 2025 • 57min
How To Deal With The Fear Of Death (Ethics Of Longevity) : 1325
In this thought-provoking discussion, Suzanne O’Brien, an end-of-life expert and hospice nurse, shares insights gained from guiding over 1,000 people through their final moments. She emphasizes that confronting mortality can lead to resilience, forgiveness, and clarity. The conversation explores how practices like gratitude and emotional reconciliation not only enhance well-being but also influence physical health and longevity. O’Brien also discusses the role of compassionate care in navigating death and the transformative lessons it offers for living purposefully.
111 snips
Sep 5, 2025 • 1h
The Hidden Traps of “Healthy” Eating (Biohacking Daily Nutrition) : 1324
Max Lugavere, health journalist and bestselling author of *Genius Foods*, joins Dave Asprey to delve into the hidden dangers of so-called 'healthy' foods. They discuss how sugar can sabotage metabolism and the pitfalls of whole grains. The conversation covers the importance of cooking methods, the impact of fasting, and the real effects of processed foods. Lugavere also challenges myths around plant-based diets and highlights the significance of culinary literacy and biocompatibility in achieving optimal health.
84 snips
Sep 4, 2025 • 1h 3min
Sulforaphane, Curcumin, and NEW GLP-1 Drugs (Biohacking for Longevity) : 1323
David Roberts and John Gildea, both Johns Hopkins-trained researchers, delve deep into the benefits of sulforaphane and its potential to enhance detox pathways and metabolism, revealing the surprising downsides of regular broccoli. They discuss how targeted supplements like curcumin and berberine can outperform traditional diets and weight-loss drugs. The conversation also includes how biohacking strategies—from fasting to nootropics—can boost brain health and performance, highlighting innovative ways to maximize nutrition without pharmaceutical side effects.
173 snips
Sep 2, 2025 • 1h 29min
Mast Cells Explained: Biohacking Inflammation, Allergies, and Brain Fog : 1322
Dr. Tania Dempsey, a functional medicine physician and co-founder of the AIM Center for Personalized Medicine, dives deep into Mast Cell Activation Syndrome (MCAS) with the host. They explore how dysregulated mast cells may cause unexplained symptoms like allergies and brain fog. Key topics include the interplay between mast cells and mitochondria, the genetic complexities of MCAS, and how environmental factors like mold contribute to chronic illness. Practical biohacking strategies are discussed, highlighting dietary shifts, hormonal balance, and managing stress to optimize health.
155 snips
Aug 29, 2025 • 1h 10min
What Is Uric Acid and How Does It Predict Your Longevity : 1321
David Perlmutter, a leading functional medicine neurologist and bestselling author, discusses the often-overlooked significance of uric acid as a crucial health marker. He reveals how uric acid influences metabolism, brain function, and longevity, and explains lifestyle factors that can spike its levels. Perlmutter also highlights innovative approaches from Japan in tracking this biomarker and emphasizes the role of diet and supplements in managing uric acid. Listeners will gain insights into optimizing their health and vitality through mindful lifestyle choices.
153 snips
Aug 28, 2025 • 1h 15min
Hacking Dopamine Naturally: Pain, Focus, and Performance : 1320
Dr. Anna Lembke, a Stanford psychiatrist and bestselling author of 'Dopamine Nation', dives into the fascinating world of dopamine and its impact on our lives. She explains how pain can actually help reset our reward systems and why our dopamine levels are crucial for motivation and mood. The discussion covers the dangers of overstimulation from modern technology and food, the benefits of cold therapy, fasting, and the societal implications of digital addiction. Lembke also highlights innovative methods like 'dopamine repair parties' to foster resilience and community.
121 snips
Aug 26, 2025 • 1h 47min
You Have A 25% Chance to Lose All Your Memory (Longevity Secrets) : 1319
Join Dr. Dale Bredesen, a world-renowned neurologist and Alzheimer's researcher, as he discusses groundbreaking strategies to prevent and even reverse cognitive decline. Discover how inflammation, toxins, and mitochondrial dysfunction contribute to Alzheimer’s. Dr. Bredesen reveals innovative biohacking techniques like fasting, supplements, and lifestyle changes to optimize brain health. He highlights the pharmaceutical industry's resistance to these solutions and shares actionable tips for young people to future-proof their brains, transforming our understanding of cognitive longevity.
