

This Week in Evolution
Vincent Racaniello
This Week in Evolution is a podcast on the biology of what makes us tick. Hosts Nels Elde and Vincent Racaniello take you through the new evolution that has been revolutionized by the field of genomics and molecular biology.
Episodes
Mentioned books

Mar 19, 2026 • 1h 18min
TWiEVO 124: The little ribozyme that could
Nels and Vincent discuss the discovery of a short RNA with the ability to catalyze its own synthesis. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Join the MicrobeTV Discord server A small polymerase ribozyme (Science) Timestamps by Jolene Science Picks Nels – The University of Illinois Just Released a Popcorn So Good It Doesn't Need Butter Vincent – Waste Wars: The Wild Afterlife of Your Trash by Alexander Clapp Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

Mar 19, 2026 • 1h 22min
TWiEVO 123: Stinkbug eggs with a schmear of fungus
Nels and Vincent explain how stinkbug females smear fungus on their eggs to protect them from wasp parasitism. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Join the MicrobeTV Discord server Defensive fungal symbiosis on insect hindlegs (Science) Timestamps by Jolene Science Picks Nels – Meet the Olympic superstar who trains under the radar in Utah Vincent – The Discovery That Changed the Universe Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

Feb 2, 2026 • 1h 15min
TWiEVO 122: The evolution of selfishness
Nels and Vincent explain how selfishness evolved multiple times from an essential tRNA synthetase gene in a nematode. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Join the MicrobeTV Discord server Evolution of selfishness from a tRNA synthetase gene (Nat Ecol Evol) Timestamps by Jolene Science Picks Nels - From Where Does it STEM? Vincent - An Act of Cosmic Sabotage Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

Jan 8, 2026 • 1h 42min
TWiEVO 121: AI imagines viruses
Nels and Vincent dive into the fascinating world of AI-designed viruses, focusing on bacteriophage phiX174. They discuss the potential and risks of AI in science, including recent NIH funding turmoil. The hosts clarify misconceptions about the paper's findings and the use of genomic language models. They explore the challenges of phage therapy, the competitive edge of synthetic phages, and the ethical considerations of bioengineering. They also emphasize the importance of robust science policy and community involvement in shaping the future of research.

Jan 8, 2026 • 1h 46min
TWiEVO 120: Sparkle pony
Nels and Vincent explain research which shows that insertion of a retrovirus into the genome regulates a novel color trait in swordtail fish. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Join the MicrobeTV Discord server Retrovirus and swordfish scale color (bioRxiv) Timestamps by Jolene Science Picks Nels – Some like it hot! A geothermal amoeba sets a new upper temperature limit for eukaryotes and Kara Marshall's talk on history of science/science funding in the US, family connections to medical care, and her own lab's work at Baylor College of Medicine Vincent – NIH shake-up to grant decision-making draws concerns of political meddling Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

Nov 4, 2025 • 1h 21min
TWiEVO 119: Drive fast, take chances, and encode a Y chromosome
Nels and Vincent explain research attempting to explain why among humans, females around the world live on average 5 years longer than males, but the trend is reversed in many birds, amphibians, and insects. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Join the MicrobeTV Discord server Sexual selection drives sex difference in adult life expectancy (Sci Adv) Timestamps by Jolene Science Picks 1:37:00 Nels – NIH Leadership Is Failing Early Career Researchers Vincent – Kennedy's Comments on Circumcision Are Only Going to Confuse and Shame Parents Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

Oct 14, 2025 • 1h 49min
TWiEVO 118: Mother of an unrelated brother
Nels and Vincent discuss research which shows a shift from the rule that living organisms produce same-species offspring: an ant that produces individuals from two distinct species. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Join the MicrobeTV Discord server David Baltimore interview (TWiV 100) One mother for two species (Nature) Timestamps by Jolene Science Picks Nels – Dr. Bill Rom, NYU canoes every lake connected by a portage trail in the Boundary Waters in Minnesota Vincent – Google just made photography obsolete Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

Aug 20, 2025 • 1h 38min
TWiEVO 117: Genes that don't leave
Nels and Vincent discuss research on hidden evolutionary constraints that dictate the retention of coronavirus accessory gene, which was flagged by NIH as potentially dangerous gain-of-function research. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Join the MicrobeTV Discord server Hidden evolutionary constraints and retention of coronavirus accessory genes (Curr Biol) Timestamps by Jolene Science Picks Nels – NIH suspends dozens of pathogen studies over 'gain-of-function' concerns and Mentorship and acts of kindness Vincent – Kennedy's case against mRNA vaccines collapses under his own evidence Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

Jul 23, 2025 • 57min
TWiEVO 116: An ant and two fungi walk into a bar and meet a naked mole rat
Nels and Vincent review research on how neuropeptides influence the behavior of leafcutter ants, and regulate the different caste behaviors such as defenders, leaf foragers, brood care, and fungus farming. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Join the MicrobeTV Discord server Neuropeptides and behavior of leaf cutter ants (Cell) Timestamps by Jolene Science Picks Nels – My academic job offer was rescinded. I'll keep going—but U.S. researchers are running out of road Vincent – There's a new acid in our rain — should we be worried? Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

Jun 18, 2025 • 1h 29min
TWiEVO 115: Even the archaea are going viral
Nels and Vincent discuss an ultra reduced archaeal genome, the closest cellular entity to date that approaches a viral strategy of existence. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Join the MicrobeTV Discord server Ultra-reduced archaeal genome (bioRxiv) Timestamps by Jolene Science Picks Nels – The Bethesda Declaration Vincent – US to Drop Guidance to Limit Alcohol to One or Two Drinks Per Day, Sources Say Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv


