

From First Principles
Krishna Choudhary and Lester Nare
From First Principles is a fast, funny, and rigorous breakdown of the biggest science stories of the week, hosted by Lester Nare and physicist Krishna Choudhary, PhD. We go past headlines into the actual mechanics: what happened, why it matters, and what everyone’s missing.
Expect physics, space, AI, energy, biotech, and the occasional “wait… is that real?” story. If you’re curious, skeptical, and you like learning in public — you’re in the right place.
Expect physics, space, AI, energy, biotech, and the occasional “wait… is that real?” story. If you’re curious, skeptical, and you like learning in public — you’re in the right place.
Episodes
Mentioned books

Aug 19, 2025 • 1h 22min
3rd Interstellar Visitor, Rubin’s Sky Camera, AI CRISPR Boost & T. rex Blood Vessels (EP. 4)
A thrilling interstellar visitor, 3I ATLAS, is speeding through our solar system, revealing clues about its comet-like origins. The Vera Rubin Observatory is set to revolutionize sky surveys with its massive 32-gigapixel camera, capturing a time-lapse of the universe. Meanwhile, AI advancements in CRISPR are enhancing gene editing precision, while groundbreaking discoveries, like preserved T. rex blood vessels, offer insights into ancient life. The episode dives deep into science, blending astronomy, genetics, and paleontology in captivating ways.

Aug 14, 2025 • 1h 17min
Oldest Molecule, Programmable Proteins, Europa Radar & Light’s Double Life (EP. 3)
Discover the mysteries of the universe's first molecule, helium hydride, and its role in star formation. Dive into groundbreaking efforts to design programmable proteins that can expand biochemical possibilities. Learn about the Europa Clipper's radar mission and what its findings might reveal about potential life beneath Europa's ice. Finally, unravel the enigma of the double-slit experiment, exploring how quantum mechanics challenges our understanding of light and reality.

Aug 5, 2025 • 1h 18min
Hidden Star in Betelgeuse, Dancing Atoms, Ultra-High-Energy Cosmic Rays & VR Immunity (EP. 2)
Discover the intriguing possibility of a hidden companion star orbiting Betelgeuse, explaining its brightness cycle. Uncover groundbreaking atomic-scale imaging techniques revealing thermal vibrations in 2D materials. Dive into the mysteries of ultra-high-energy cosmic rays and the IceCube detector's findings on particle origins. Explore how New Horizons validated interstellar navigation using star patterns. Finally, learn about an innovative VR study showing that visual stimuli can boost immune responses, linking sight to health in surprising ways.

Aug 1, 2025 • 56min
Earth’s 1-ms Day, Baby Solar Systems, Record Black Hole Crash, CRISPR Cancer Hack & AI Indiana Jones (EP. 1)
Last week the Earth finished a full rotation one millisecond early – but that’s just the opener.In this week’s From First Principles we dive into six mind-bending headlines with our trademark mix of hard science and light-hearted banter:Earth’s fastest spin ever recorded – what shaved a millisecond off the day and why your chakras are still safe.ALMA spots a “baby Earth” forming 1,300 light years away – the first direct look at rocky planets in the making.Biggest black-hole merger on record – 15 ☉ of mass vaporized into pure gravitational waves, detected by LIGO/Virgo/KAGRA.CRISPR reveals a vitamin-D “kill switch” for tumors – how silencing one gene in pancreatic & colon cancers triggers 4,000 downstream changes.A star that died… then died again – the first confirmed “double-detonation” white-dwarf supernova.DeepMind’s Aeneas AI deciphers broken Latin tablets – giving historians new text, provenance and dating in seconds.👋 Hosts • Lester Nare – storyteller & professional curiosity machine • Dr. Krishna Choudhary – Princeton-trained physicist & cosmic tour guide👍 Like what you hear? Hit Subscribe, ring the bell 🔔, and drop your questions for next week’s episode.


