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A surprise acquisition kicks things off, along with promises of editorial independence and plenty of jokes. Then the conversation turns to Artemis II, with moon-mission hype, NASA visuals, and the thrill of humans heading back toward deep space. It also dives into a two-person telehealth company using AI to scale to a staggering $1.8 billion.

Gaurav Misra, Mirage CEO behind Captions, joins Justin Levine, Shepherd co-founder building AI insurance, Jeremy Allaire, Circle co-founder behind USDC, Adam Meyers, CrowdStrike threat hunter, and Marc Lore, Jet.com founder now leading Wonder. They get into moon missions, one-person billion-dollar companies, giant dealmaking, AI-built restaurants, cyberattacks, digital dollars, and the data center boom.

Moon-shot drama leads the way, from Artemis II and the fight over a real lunar economy to Neil Armstrong’s wild training crash and NASA’s plan for near-live moon footage. Then it shifts to Jamie Dimon’s push to revive American growth, Snap’s activist-fueled pressure campaign, a bizarre KitKat heist, and a quick IPO tease from Elon.

Eddy Cue, a longtime Apple leader behind iTunes and major services, looks back on joining in the early days and being pulled in by Steve Jobs’ product obsession. He revisits the risky launch of the first online store. He also gets into how iPod and iTunes reshaped Apple’s strategy, why 99-cent music clicked, and how F1 fits into Apple’s bigger sports push.

Eddy Cue, Apple services veteran behind iTunes and the App Store, looks back on Apple’s reinvention and early online bets. Aaron Terrazas, Gusto economist, digs into small-business hiring. Pratap Ranade, Arena Physica founder, talks AI for electromagnetism. Abhishek Das of UTOTI explores web agents. Garry Tan of Y Combinator and Brannin McBee of CoreWeave jump into AI coding, chips, power, Artemis, Snap, and SpaceX IPO buzz.

AI-made memes and viral video remixes kick things off with internet chaos. Then it jumps to a malware scare tied to the Axios hack and a leaked Claude Code file drama. Crypto faces a possible quantum countdown. There is also moon livestream tech, a simple deepfake test, and Elon Musk’s long-running push to steer AI labs.

Alex Pruden, Project Eleven co-founder and ex-Green Beret, joins Qasar Younis of Applied Intuition, finance writer Sebastian Mallaby, and founders Chris Yu, Will Ahmed, Dino Mavrookas, Forrest Heath, and Jannick Malling. They dig into AI-made memes, the Axios npm breach, a Claude Code leak, quantum risk to crypto, autonomous machines, new internet pipes, shipbuilding, wearables, and AI-powered investing.

Courtroom battles over teen addiction kick things off, with a sharp debate over whether social platforms and video apps belong in the same box. Then it jumps to how old cartoons eerily predicted AI-powered work. There’s also a quick spin through massive AI infrastructure, Bill Ackman’s market-moving financial bets, and why the next trip around the moon deserves way more hype.

Tae Kim, a technology analyst and author covering semiconductors and AI infrastructure, breaks down why Nvidia still looks strong in the AI race. The conversation hits inference demand, supply lockups, GPU and CPU shortages, open models, vertical AI agents, and why fears around depreciation, pullbacks, and a future compute glut may be overdone.

Tae Kim, chip-market analyst behind Key Context, joins Logan Bartlett, Redpoint investor, plus builders Sam Stephenson of Granola, Ben Broca of Polsia, Brett Adcock of Figure AI, and Andrei Serban of Console. They dig into the lawyer who beat Meta and Google, Nvidia jitters, software valuation chaos, robot futures, Japan Twitter, and why hotel tech still feels cursed.