The Life Scientific

Professor Sir Michael Rutter has been described as the most illustrious and influential psychiatric scientist of his generation. His international reputation has been achieved despite the fact that as a young doctor, he had no intention of becoming a researcher, nor interest in becoming a child psychiatrist. In fact he became a world leader as both.His career has spanned more than five decades and is marked by a remarkable body of high-impact research and landmark studies. The theme running through all his work has been child development, on the subtle interplay between nature and nurture and on the factors that make the difference between a child flourishing, or floundering.Evacuated during World War Two, to a Quaker family in the USA, Mike Rutter tells Jim Al-Khalili about the impact this move, aged seven, had on him. He describes the inspirational teachers who persuaded him that research and clinical work as a child and adolescent psychiatrist, was for him, and he admits that an early mentor insisted he mustn't receive any formal training in child psychiatry, something he hasn't received to this day!He was awarded this country's first ever professorship in child psychiatry in 1973 and he's credited with founding the field of developmental psychopathology. This involves the study, over time, of normal and abnormal child development. He's currently Professor of Developmental Psychopathology at King's College, London and still a practicing child psychiatrist.An early breakthrough was his discovery that autism, or infantile psychosis as it was then known, had a genetic basis, something barely suspected at the time.Beautifully designed studies of populations over time followed, many of them landmark studies still cited today. They established the framework for studying and investigating mental illness in the community. The Isle of Wight Studies (1964-74) surveyed the mental health of children living on the island and for the first time in such research, children themselves were directly interviewed and questioned. Before this, Mike Rutter tells Jim, the assumption had been that what children thought and said didn't really matter.In the 1970s, the Fifteen Thousand Hours study, delivered ground-breaking evidence about the combination of factors that affected the performance and behaviour of children in inner city secondary schools. Findings from this study were included by both the Labour and Conservative parties in their 1979 election manifestos."Maternal Deprivation Reassessed" was Mike Rutter's challenge to John Bowlby's hugely influential theory of maternal attachment. It was described as "a classic in the field of childcare" and it transformed the debate about the relationships that help babies to flourish.His fascination with the underlying reasons why and how children vary in their ability to weather and cope with adversity, led to the growth of resilience science. For more than 40 years Mike Rutter, "the intellectual father", has led this field of study.His name is particularly associated with "natural experiments" and one of the best known is the English Romanian Adoptees study that he set up in the early 1990s and still runs today. The children being followed are those rescued from the orphanages of Nicolai Ceausescu and adopted by families in this country. Because of the appalling conditions many of these babies and toddlers experienced in Romanian institutions, Professor Rutter understood that tracking and studying them as they grew up in loving homes here, would provide important insights into how early deprivation affects children's development.Producer: Fiona Hill.

Jim Al-Khalili's guest this week is Dame Julia Slingo, the chief scientist at the Met Office. The conversation ranges from her childhood wonder of clouds to climate change's part in this winter's floods.Julia Slingo's fascination with meteorology began as she, as a sixth former, gazed out of her bedroom window and wondered what controlled the shapes of clouds and why the clouds usually came from the west. In the 1970s she was one of the few women scientists at the British Meteorological Office and worked in the early days of computer modelling of weather and climate. As the first female professor of Meteorology in the UK, she crusaded for greater computing power and capacity to improve both weather forecasting and global climate models.Julia Slingo took up the job of the chief scientist at the Met Office in 2009. Her profile has been high in the last few months following her remarks that the persistent heavy rains and storminess of Winter 2013 to 2014 were likely to be linked to anthropogenic climate change.

Charles Darwin described the eye as an 'organ of extreme perfection and complication'. How this engineering marvel of nature forms out of a few cells in the developing embryo has been the big question for Veronica van Heyningen, emeritus professor at the MRC's Institute of Genetics and Molecular Medicine at the University of Edinburgh.Veronica is a world lead in the genetics of the development of the eye. She tells Jim Al Khalili about her part in the discovery of a gene called Pax-6 which turned to be a master builder gene for the eye, in all animals which have eyes - from humans to fruit flies.As she explains, further research on this gene may eventually help people with the genetic vision impairment, Aniridia. It was Veronica's research on patients with this condition which led to the gene's final discovery. She tells Jim about why it's important for scientists to engage in public discussion on the ethical implications of their work.Veronica also talks about her arrival in Britain as an 11 year old. Her family escaped from communist Hungary in 1958. Both of her Jewish parents had been sent to Nazi concentration camps during the Second World War.

Alf Adams FRS, physicist at the University of Surrey, had an idea on a beach in the mid-eighties that made the modern internet, CD and DVD players, and even bar-code readers possible. You probably have half a dozen 'strained-layer quantum well lasers' in your home.

Anne Glover is currently one of the most influential scientists in Europe. She advises the President of the European Commission on the research behind issues ranging from nuclear power to genetically modified foods. She talks to Jim al-Khalili about how she makes an impact working across the many countries in Europe with different ideas about science. For example, Germany and France have very different attitudes to nuclear power.Anne Glover is also a Professor at Aberdeen University where she uses glow in the dark microbes to solve problems such as polluted land. It's a technique she developed after seeing minute glowing creatures while swimming at night in the Algarve.She tells Jim about her life in the lab, setting up a company to exploit her bioluminescent microbes and how she gets on in the world of politics.

Mark Miodownik's chronic interest in materials began in rather unhappy circumstances. He was stabbed in the back, with a razor, on his way to school. When he saw the tiny piece of steel that had caused him so much harm, he became obsessed with how it could it be so sharp and so strong. And he's been materials-mad ever since.Working at a nuclear weapons laboratory in the US, he enjoyed huge budgets and the freedom to make the most amazing materials. But he gave that up to work with artists and designers because he believes that if you ignore the sensual aspects of materials, you end up with materials that people don't want.For Mark, making is as important as reading and writing. It's an expression of who we are, like music or literature, and 'everyone should be doing it'. To this end, he wants our public libraries to be converted into public workshops, with laser cutters and 3 D printers in place of books.

Jim Al-Khalili talks to psychiatrist Vikram Patel about the global campaign he is leading to tackle mental health. He reflects on his early career working in Zimbabwe, when he doubted any western diagnoses or treatments for peoples' distress would be of much use. However, his subsequent research made him question this and come to the realisation that some conditions, like depression and psychosis, could be tackled universally. Now based in India, Vikram's research guides the public health approach he is taking. Yet critics question the application of Western categories for diagnosis and treatment to other parts of the world.Producer: Beth Eastwood.

Forensic anthropologist Professor Sue Black began her career with a Saturday job working in a butcher's shop. At the time she didn't realise that this would be the start of a lifelong fascination with anatomy.Her job has taken her to some extreme and challenging locations to identify human bodies, such as Kosovo, where she uncovered evidence used in the UN's War Crimes Tribunal in The Hague.Back home, Sue has been integral in solving many high-profile criminal cases, including cracking Scotland's biggest paedophile ring in 2009.In The Life Scientific, Jim Al-Khalili asks how she deals with the emotional pressures of the job, and why she is so fascinated by the inner workings of the human body.In her spare time, Sue Black also advises crime fiction authors like Val McDermid, providing inspiration for new plotlines and characters.In return, Val and a group of writers have offered to help with Sue's latest challenge - fundraising for a mortuary. This facility will use new techniques to embalm bodies and promises to revolutionise the way surgeons are trained.Producer: Michelle Martin.

Peter Higgs opens up to Jim Al-Khalili, admitting that he failed to realise the full significance of the Higgs boson and to link it to the much celebrated Standard Model of Physics. An oversight he puts down to a string of missed opportunities, including one night at physics summer camp when, most regrettably, he went to bed early.Working alone in Edinburgh in the sixties, Peter Higgs was considered 'a bit of a crank'. 'No-one wanted to work with me', he says. In 1964, he predicted the possible existence of a new kind of boson but, at the time, there was little interest in his boson. And in the years that followed, Peter Higgs says, he was 'looking in the wrong place for the application'.Three years later, the Higgs mechanism was shown to be central to the new Standard Model of Physics, which brings together three of the four fundamental forces of nature and has dominated physics ever since. Higgs met one of the key architects of the Standard Model several times, but they failed to realise they were working on the same thing. He particularly regrets one night at physics summer camp when he decided to go to bed early. The others meantime stayed up all night working up The Standard Model.The seventies was an exciting time for particle physics but Higgs says he 'struggled to keep up'. His PhD was in a different field and he says he 'lacked technical competency'. He says work pressure contributed to the breakdown of his marriage and that perhaps he suffered a personality change in the mid-sixties when he realised his research might be on to something good and started working harder.Four decades and several billion pounds on, scientists at the Large Hadron Collider at CERN confirmed that the Higgs boson had indeed been found and Peter Higgs shot to fame.This ephemeral speck of elusive energy is now so well-known it's featured in car adverts and countless jokes. There's even song by Nick Cave called the Higgs Boson Blues. But Higgs has always called it the 'scalar boson' and remains embarrassed that it is named after only him.Three different research groups, working independently, published very similar papers in 1964 describing what's now known as the Higgs mechanism. And Higgs remains surprised that another British physicist, Tom Kibble from Imperial College, London didn't share the 2013 Nobel Prize for Physics along with him and Belgian physicist, Francois Englert."[Kibble] wrote a longer paper which was really very important in generalising the sort of thing I had written in '64 ", says Higgs.Peter Higgs found physics boring, as it was taught at school. He was going to be an engineer, like his father, but was clumsy in the lab and, he says, became a theoretical physicist 'by default'.When the 2013 Nobel Prize winners were announced, many assumed Higgs was blissfully unaware that he might win or just not that interested. In fact, he left the house quite deliberately that morning fully expecting the Nobel Committee to call.These days, he's constantly stopped in the street and asked for autographs and photographs which, he says, is 'nice but a bit of a nuisance'.Producer: Anna Buckley.

Dame Wendy Hall, Professor of Computer Science at the University of Southampton, has spent a career at the forefront of developments around the web and digital media. Trained as a mathematician, she moved to the fledgling department of computer science in the mid 1980's, a time of great change and great excitement in the field.She talks to Jim Al Khalili about the rate that things have changed, how the web is still not quite what it should be, and about the new discipline she has helped to found known as Web Science.