Astral Codex Ten Podcast

https://astralcodexten.substack.com/p/a-modest-proposal-for-republicans Read this first: Book Review: Fussell On Class Dear Republican Party: I hear you're having a post-Trump identity crisis. Your old platform of capitalism and liberty and whatever no longer excites people. Trump managed to excite people, but you don't know how to turn his personal appeal into a new platform. Most of what he said was offensive, blatantly false, or alienated more people than it won; absent his personal magic it seems like a losing combination. You seem to have picked up a few minority voters here and there, but you're not sure why, and you don't know how to build on this success. I hate you and you hate me. But maybe I would hate you less if you didn't suck. Also, the more confused you are, the more you flail around sabotaging everything. All else being equal, I'd rather you have a coherent interesting message, and make Democrats shape up to compete with you. So here's my recommendation: use the word "class". Pivot from mindless populist rage to a thoughtful campaign to fight classism. Yeah, yeah, "class" sounds Marxist, class warfare and all that, you're supposed to be against that kind of thing, right? Wrong. Economic class warfare is Marxist, but here in the US class isn't a purely economic concept. Class is also about culture. You're already doing class warfare, you're just doing it blindly and confusedly. Instead, do it openly, while using the words "class" and "classism".

https://astralcodexten.substack.com/p/book-review-fussell-on-class I. Paul Fussell wants to talk about class. (well, wanted, past tense, it's a 1983 book, we'll come back to that later) He recognizes this might not be the most popular topic. When he tells people he's writing a book on class in America, "it is as if I had said I am working on a book urging the beating to death of baby whales using the dead bodies of baby seals." America likes to think of itself as a classless society. Sure, there may be vast wealth inequality, but at least there's no nobility; beggars and billionaires are the same type of citizen. Paul Fussell will have none of it. He believes America has one of the most hypertrophied class systems in the world, that its formal equality has left a niche that an informal class system expanded to fill - and expanded, and expanded, until it surpassed the more-legible systems of Europe and became its own sort of homegrown monstrosity. He says he prefers the term "caste system" to "class system" when describing America, conveying as it does a more rigid and inescapable distinction, and that he uses "class" only out of respect for conventional usage.

https://astralcodexten.substack.com/p/mantic-monday-judging-april-covid Since this is getting broader than just Metaculus, I'm changing the name to Mantic Monday, after an obscure word for "oracular" (and changing the preview image to a mantis, since I don't know how else to visually represent "mantic". And posting it early Tuesday morning because I'm late). In April 2020, I made my yearly predictions, and many of them were about the (then new) coronavirus pandemic. Two other people on Less Wrong, Zvi and Bucky, decided to test themselves against me by trying to predict the same questions. Zvi saw my answers beforehand; Bucky didn't. Here's how we did (except where otherwise stated, all predictions are for 12/31/20): Black statements are those judged true, red statements false. The numbers on the left are our predictions, so for example I said there was a 60% chance that Bay Area lockdowns would extend beyond June 15. You can see a list of the full questions and why I graded them the way I did in the appendix at the bottom. I scored these using a logarthmic scoring rule, adjusted so that guessing 50-50 always gave zero points. It's not very intuitive. Getting everything maximally right gives a score of about 14; guessing 50-50 for everything gives a score of 0, getting everything maximally wrong gives a score of negative infinity.

https://astralcodexten.substack.com/p/a-look-down-track-b I. Depression probably has something to do with decreased synaptogenesis in the brain, maybe the hippocampus in particular. Neurons are less likely to respond to stimuli by connecting to other neurons. The whole network becomes sparser than usual, and dysfunctional thought-loops that thrive in sparse network conditions start taking over. We understand parts of the pathways that regulate synaptic growth. When the body wants more synapses, it releases neurotrophic hormones like BDNF (brain-derived neurotrophic factor). These activate various receptors including tropomyosin receptor kinase B (TrkB, affectionately pronounced "track B" because it's one of two related pathways for these signals). TrkB then something Ras mTORC something something synaptogenesis now you're not depressed anymore hooray. Pictured: BDNF binds to TrkB. The IRS confiscates 1/2 of it as taxes, which radicalizes the receptor and makes it join Gab (see footnote 1), where it tweets out an SOS message to the Ras of Ethiopia. But the left wing of the receptor joins the Palestine Liberation Council and moves to California (see footnotes 2+). California has sunshine and good beaches, so you stop feeling depressed. This part sort of makes sense. But it coexists uneasily with other puzzle pieces in our knowledge of depression. For example, we give people SSRIs, their serotonin levels go up, and this makes them feel better. Why? Because of BDNF something TrkB something mTORC something? Probably; mice with dysregulated BDNF/TrkB systems don't benefit from antidepressants. But why does more serotonin cause BDNF something TrkB something? I've looked for years for a paper that says something like "by the way, serotonin makes cells release more BDNF". But despite a few suggestive links I don't see anyone strongly asserting that they understand this.

https://astralcodexten.substack.com/p/ezra-klein-on-vetocracy In my review last week of Ezra Klein's Why We're Polarized, I linked to a related Vox article on vetocracy: In a viral essay, venture capitalist Marc Andreessen makes a simple exhortation: It's time to build. Behind the coronavirus crisis, he writes, lies "our widespread inability to build." America has been unable to create enough coronavirus tests, or even enough cotton swabs to fully utilize the tests we do have. We don't have enough ventilators, ICU beds, personal protection equipment. The government hasn't built the capacity to quickly get money to people or businesses who need it. And it's not just the coronavirus. The US could be building our way out of the housing crisis and the climate crisis. We could be building a better education system, more advanced infrastructure. We could have more and better factories, supersonic aircraft, delivery drones, flying cars [...] I think Andreessen is uncharacteristically underestimating the appetite for building. The absence of creation doesn't reflect an absence of desire — even in that epicenter of supposed stagnation, Washington, DC. I've covered Congress for almost 20 years. The place is littered with proposals to construct universal pre-K and reimagine the health system, to decarbonize the US economy and incentivize drug development through prizes and solve the housing crisis. They just don't pass. It's become a running joke in Washington that every week is "infrastructure week." But we're not rebuilding American infrastructure

https://astralcodexten.substack.com/p/highlights-from-the-comments-on-cult DeBoer argued that charter schools succeed through selection effects: they only take the best students. Several commenters pointed out this was illegal. It is, but they've found loopholes. Here's Alexander H: I attended a charter school all 4 years quite recently. Admissions was entirely by lottery, open to everyone in the district. I can tell you that even in freshman year, the student body was not even remotely close to representative of normal kids; it was basically an entire school of the kids who would normally be in gifted / accelerated programs. And by graduation, it was even more refined to super talented & smart people, because the students who left to go back to their local normal schools were mostly from the rear of the pack. I think that I got a lot better of an education there than I would have at my local school, and I would attribute more of that to the quality of my classmates than to the teachers or curriculum , though both of which were also better [...] [Despite the lottery, admission was selected by] whose parents were involved enough, interested enough in education, valued education enough. Simple as that, I think. Michael Pershan recommends his own review of a book on Success Academy. A key quote:

Freddie DeBoer challenges the narrative of failing education in America in 'The Cult Of Smart'. He argues that education isn't declining, race and gender gaps are stable or decreasing. Critiques tough education reforms and advocates for reevaluation of meritocracy. Explores universal pre-K benefits and critiques traditional schooling system for limiting freedom and creativity.

https://astralcodexten.substack.com/p/covidvitamin-d-much-more-than-you Most health articles ask you to act on their opinions. I am specifically asking you not to act on mine. In a moment, I'll tell you whether or not I think Vitamin D prevents or treats coronavirus. But I'll give you a free spoiler: I am less than 100% certain of what I'm about to say. So if you want to take Vitamin D, take it. If it does prevent or cure coronavirus, great. If not, the worst that will happen is you'll have slightly better bone health. I can't stress how much I don't want to be those people who said they couldn't prove face masks helped so you must not use face masks. Just ignore everything I'm saying, do a quick cost-benefit calculation, and take Vitamin D. That having been said: Lots of people think Vitamin D treats coronavirus, and some of them have good evidence. For example, infection rate from coronavirus seems latitude dependent; in general, the further north an area, the worse it's been hit. Northern areas get less sunlight, and sunlight helps produce Vitamin D, so whenever you see a disease that's worse at high latitudes, Vitamin D should be on your short list of potential causes. Also - in the US, COVID seemed to remit with the summer and worsen over the winter. It's hard to distinguish this from general exponential growth and from the effect of playing ping-pong with gradually loosening/ tightening lockdowns, but the US spike this winter was pretty dramatic. Most Northern Hemisphere countries show such a pattern, most equatorial countries don't, and some Southern Hemisphere countries arguably show the opposite. Whenever you see a disease that's better in summer and worse in winter, Vitamin D is one of the possible culprits.

https://astralcodexten.substack.com/p/coronavirus-links-discussion-open So far there have been three waves of coronavirus cases in the US. The first wave was the beginning, when it caught us unprepared. The second wave was in July, when we got sloppy and lifted lockdowns too soon. The third wave was November through January, because the coronavirus is seasonal and winter is its season (also probably the holidays). From Johns Hopkins CRC: A fourth wave may hit in March, when the more contagious B117 strain from the UK takes over. Expect more shelter-in-place orders, school shutdowns, and a spike in cases at least the size of July's, maybe December's. That will last until May-ish, when the usual control system (more virus -> stricter lockdowns -> less virus -> looser lockdowns -> more virus) moves back into the "less virus" stage. Also coronavirus is seasonal and summer isn't its season. Also by that time a decent chunk of the population will be vaccinated. The worst consequences of the UK strain should burn themselves out by late spring.

https://astralcodexten.substack.com/p/statement-on-new-york-times-article There was recently a negative article about me and my blog in the New York Times. Most of you already know the history behind this, but for anyone referred here by NYT, this is where I give my side and defend myself. Like many people in the early 2000s, I started a blog when I was in college. To stay anonymous, I wrote it under my first and middle names – Scott Alexander – while leaving out my last name. I continued writing in it through medical school, residency, and until the present. Although I've never personally been involved in the tech industry, my blog became very popular among people in tech because it discussed ideas centering around scientific and technological progress, especially artificial intelligence. In early 2020, I learned the New York Times wanted to write an article about me. They had discovered my real name and wanted to reveal it to the world. Their original pitch – and I don't know if it was true or not – was that they were interested in how I warned about the coronavirus pandemic very early and urged people to wear face masks before this was standard advice.