Health Check

“Diet and exercise” has been the weight-loss mantra for decades but a drug designed for diabetes patients could now offer hope to people who are obese, at a time when researchers are warning that half of the world’s population are expected to be overweight or obese by 2035. One of the first to have injections of Semaglutide in the UK was Jan, who has battled with her weight since childhood. Once the medication took effect she lost four stone and said her hunger disappeared. Professor Stephen O’Rahilly from the University of Cambridge, explains how the drug mimics our body’s natural appetite signalling but its effects disappear once you stop the weekly injections. Family doctor Margaret McCartney says it might help some who are obese but warns that it has also gained a reputation as a “Hollywood skinny drug", reflecting some of society’s ideas about beauty and celebrity culture. Presenter: Claudia Hammond Producer: Paula McGrath(Photo: A jogger running around Clifton Downs, Bristol. Credit: Ben Birchall/PA)

A month on from the devastating earthquakes in Turkey and Syria, we assess what kind of impact the disaster may have had on mental health. We hear from Professor Metin Basoglu, an expert in earthquake trauma and director of the Istanbul Centre for Behavioural Sciences. He explains how it is a unique kind of trauma rooted in fear and compounded by the uncontrollable nature of earthquakes and the thousands of aftershocks that come following the initial disaster. Prof Basoglu tells us about the psychological treatment he developed based on his research with 10,000 survivors of the 1999 earthquake in Turkey and how an earthquake simulator can be used to tackle trauma symptoms. We hear from researchers in the US and Kenya about a new discovery that has ended 100 years of searching for an airborne chemical that could hold the key to the way tsetse flies mate – and help to tackle the diseases they spread in humans.Our guest in the studio is family doctor Ann Robinson who has the latest research on global health. Could socialising more often be linked to a longer life? And why might half of the world’s population be obese by 2035? We’ll explore all this and more. Presenter: Claudia Hammond Producer: Gerry HoltImage: Survivors of the earthquake in the city of Jenderes in the countryside of Aleppo, north-western Syria. Credit: NurPhoto / Contributor

We delve into the science of how some vaccines could have unexpected effects beyond their intended target. They are called “non-specific effects” and we are only just at the beginning of our understanding despite scientists documenting this curious biological phenomenon more than 100 years ago. One of the earliest vaccines to be studied was the Bacillus Calmette-Guérin vaccine for Tuberculosis, better known as the BCG. Professor Christine Stabell-Benn gives us a history lesson and brings us up to date with her team’s research at the Bandim Health Project in Guinea-Bissau, Western Africa. Also in the programme we hear about a new device for fixing bones being trialled in Gaza and Sri Lanka – and already in use in Ukraine. We hear from surgeons about what kind of patients they are treating and from UK researchers on hopes it will offer a low-cost, easy-to-make alternative in countries where there are shortages of these fixators.Our studio guest this week is BBC News health and science journalist Philippa Roxby who talks us through the latest after an 11-year-old girl in Cambodia died from the H5N1 strain of bird flu. Plus, we look at new studies on long Covid and how much exercise we should be aiming to do each day.Presenter: Claudia Hammond Producer: Gerry Holt and Emily Knight

From human milk banks to babies born during conflict, this week we're all about the health of children and newborns.The most vulnerable premature babies benefit from human milk, but their mother's milk is often not available. We visit a human milk bank to explore how donors are making a difference.Dr Ann Robinson shares some surprising new research looking at a novel way of preventing short-sightedness. And one year on from the start of the war, Smitha Mundasad talks to a Ukrainian mother who was forced to flee her country while 7 months pregnant. In conversation with Sasha Yarova from War Child, Smitha finds out about support available for the thousands of Ukrainian children now making new homes in countries around Europe. Presenter: Smitha Mundasad Producer: Gerry Holt & Ilan Goodman

Venomous snakebites are responsible for up to 150,000 deaths a year around the world – and they also leave around half a million survivors with life-changing injuries, including amputations and disfigurement. In this week’s Health Check we investigate why snakebite still disproportionately affects poorer, more rural communities, and what is being done to tackle the problem.We’ll talk to a mother in Kenya whose little girl was bitten by a snake not once, but twice, and to a doctor about how it feels to save lives. We’ll hear how anti-venoms are checked and how in many cases they are too expensive to afford and how there are not always enough supplies. And even when they are available some don’t work well.Smitha Mundasad also visits the Centre for Snakebite Research and Interventions in Liverpool, England, where she gets to see a snake being “milked” for its venom – and finds out how new and improved anti-venoms are being created, all with a little help from camels. Join us on a journey crossing continents, from the front line of the fight against snakebite to the hunt for new therapies.Image: Herpetologist Edouard Crittenden “milking” a snake for its venom.Presenter: Smitha Mundasad Producers: Gerry Holt & Julia Ravey

Can changes in the weather have an impact on our mental health? We go to Bangladesh in South Asia, a country on the front line of the impacts of climate change, where researchers have been exploring connections between incremental changes in heat and humidity, along with bigger impacts like flooding, and the levels of anxiety and depression in the population. They say their study has stark implications, not just for Bangladesh, but for many other countries too. Dr Belinda Fenty joins us bringing in some coffees in the studio. But can presenter Smitha Mundasad spot which cup has the caffeine? Dr Fenty talks us through what coffee actually does to the body and ponders other questions like how much is too much and why might you crash after a coffee high.She also take us through how to spot fake medicines and we take a look at an intriguing study on whether being married is good for your health. Presenter: Smitha Mundasad Producer: Gerry Holt(Photo: Pabna in Bangladesh at dusk. Credit: Emon Cena/Getty Images.)

This week we’re dedicating the programme to a common medical emergency – one that can be deadly within minutes without the right help to hand. A cardiac arrest is when the heart suddenly stops pumping blood around the body. We’ll hear from a doctor who battled for five hours to save a man 40,000ft up in the air; a student who’s teaching people not to be afraid to help in an emergency and we’ll hear a survivor’s story of life after cardiac arrest. Globally, there are tens of thousands of cardiac arrests outside of hospital every year. Fewer than one in 10 survive and this number varies depending on where you live, as does the availability of life-saving defibrillators – our studio guest Dr Belinda Fenty tells us more. Cardiopulmonary resuscitation (CPR) in the first few minutes after the heart stops beating can be crucial. We have a live demo from a volunteer with UK charity St John Ambulance. Join us for an action-packed programme that might just help you save a life.Image: Dr Vishwaraj Vemala is thanked by the captain of the Air India flight after he saved a fellow passenger’s life Presenter: Smitha Mundasad Producer: Gerry Holt

Six months on from the worst flooding in Pakistan’s history, a medic in eastern Balochistan describes what he is seeing daily.Khalid Saleem, who works for the charity Médecins Sans Frontières (Doctors Without Borders), says many people are still living in shelters at the side of the road and must walk miles if they need healthcare. There are high levels of malnutrition, malaria and skin conditions such as scabies.We also talk Professor Zainab Samad, from Aga Khan University in Islamabad, who is the author of a major new report on the country’s health. She describes how people in these areas were already worse off even before the floods and says it will take years to recover – but it is everyone’s responsibility to help make society healthier. We hear from Dr Lindsay Dewa and medical student Simi Adewale on their project to explore digital connection during the COVID-19 pandemic. Imperial College London worked with young people to make a short film about the impact on young people’s mental health.And our guest is family doctor Ann Robinson, who’ll discuss the latest studies and health news, including strict new alcohol guidance for Canada and how “bed dancing” is helping hospital patients.Image credit: Getty ImagesPresenter: Smitha Mundasad Producer: Gerry Holt

In this week’s episode we hear from two women who talk about what life is like with endometriosis, an incredibly common but debilitating condition where tissue similar to the lining of the womb grows in other places in the body. Katherine from Ghana and Dee from Wales describe their long journeys to diagnosis and how the “invisible illness” affects every aspect of their lives, from mental health to work and relationships.We also hear from a researcher in the US who is studying the condition in minute detail in the hope that arming the scientific community with deeper knowledge will help lead to new treatments.Presenter Smitha Mundasad joins a singing group in London which aims to tackle post-natal depression among new mums. She hears how the project, which is rooted in research, is challenging them artistically and helping to reduce symptoms.Also joining us is Matt Fox, Professor of Epidemiology and Global Health at Boston University, who’ll discuss what progress is being made in the fight to eradicate rabies by 2030 and talk us through a study on the best music to fall asleep to… Zzz…Presenter: Smitha Mundasad Producer: Gerry Holt

In this week’s episode of Health Check, we meet the Poulin family who live in Thailand. They tell us about their long quest to have their little girl Rylae-Ann diagnosed with an incredibly rare disease. And that’s just the beginning of the story.Rylae-Ann was fortunate enough to have gene therapy on a clinical trial in Taiwan – and it has transformed her life – but it’s not a treatment that’s available to everyone. Joining presenter Smitha Mundasad in the studio is family doctor Graham Easton, who’ll discuss why that’s the case – and what the risks are around this experimental treatment and the ethics of diagnosing rare conditions.We’ll also hear from a scientist in Vancouver on her fascinating research which has discovered a compound in a sea sponge that blocks Covid-19 in human cells in the lab.And we’ll have the latest on the virus in China, as concerns grow about its spread ahead of the Lunar New Year, and a rather unusual study about a very small trial in London involving scars being treated using transplanted hair.Presenter: Smitha Mundasad Producer: Gerry Holt and Tess Davidson