The Stem Cell Podcast

Dr. Hongkui Deng, Director of the Institute of Stem Cell Research at Peking University, and Dr. Candice Liew, Senior Scientist at Reprogenix Bioscience, share their groundbreaking work on chemically induced pluripotent stem cells (CiPSCs). They discuss a revolutionary patient trial using CiPSC-derived islets for type 1 diabetes and the challenges of immune tolerance. The pair also delve into advancements in chemical reprogramming and their potential to transform regenerative medicine, including innovative strategies for age reversal and enhanced disease treatment.

In June 2025, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Hong Kong, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the final of four episodes from the meeting. Sessions focused on cell therapy for spinal cord injury, immunocompatible pig organs, and community engagement. Featured Products and Resources: Are you taking a cell therapy to clinic? Work with a dedicated team that understands the path from bench to bedside. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In June 2025, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Hong Kong, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the third of four episodes, where Daylon and Arun discuss research on cell therapy for inflammatory bowel disease and hearing loss. They also talk about Dr. Jacob Hanna’s work on ex utero embryo culture, Dr. Paola Arlotta’s research on long-term brain organoids, and Di Pan’s insights into sponge regeneration. Featured Products and Resources: Get access to free, on-demand training courses to help you master techniques in hPSC, hematopoietic, organoid, neural, and other specialized cell types. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In June 2025, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Hong Kong, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the second of four episodes, where Daylon and Arun cover talks on animal models of regeneration and the public perception of in vitro gametogenesis. They also discuss work on CiPSCs for Type 1 diabetes therapy and growing pig-human chimeric embryos. Featured Products and Resources: Explore the possibilities for reproducible, high-quality hPSC differentiation with easy-to-use serum-free kits. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In June 2025, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Hong Kong, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the first of four episodes, where Daylon and Arun discuss updates from clinical trials for ALS, congenital heart disease, and Parkinson’s disease. They also talk about the Presidential Plenary session, chaired by Dr. Valentina Greco. Featured Products and Resources: Start your research confidently with a reliable source of human iPSC products. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Dr. Maneesha Inamdar, a leading figure in stem cell science, discusses innovative research in cardiovascular development. She shares insights on using embryo models to explore teratogenicity and the importance of prioritizing ethnically diverse cell lines. The conversation also highlights groundbreaking advancements in vascularized cardiac organoids for drug testing and insights into dilated cardiomyopathy through iPSCs. Inamdar emphasizes the need for global representation in scientific discourse, particularly for Indian scientists, and stresses the ethical considerations in stem cell research.

Guests: Dr. Jacqueline Barry is the Chief Clinical Officer at Cell and Gene Therapy Catapult, Dr. Kapil Bharti is a Senior Investigator at the National Eye Institute at the National Institutes of Health, and Dr. Jack Mosher is the Scientific Director at the International Society for Stem Cell Research (ISSCR). They discuss their work on the ISSCR’s Best Practices for the Development of Pluripotent Stem Cell-Derived Cellular Therapies. They talk about the need for consistency and rigor in cell therapy development, and how the document can be navigated and applied across jurisdictions. (44:59) Featured Products and Resources: ISSCR 2025 is happening June 11-14 in Hong Kong! Enter to win a personalized lab coat! The Stem Cell Science Round Up Gene Editing for a Rare Genetic Disease – A customized lipid nanoparticle-delivered base-editing therapy was used to treat a neonate with severe carbamoyl-phosphate synthetase 1 deficiency. (2:00) Digitalized Organoids – An AI-powered pipeline allows for plug-and-play image analysis of diverse 3D cellular structures across multiple imaging resolutions. (13:30) Post-Gastrulation Amnioids – Amnioids mimic the cellular identities, proteome, and metabolome of the human amniotic sac. (24:00) Cerebral Cortex Expansion – A human accelerated region enhancer modulates cortical development by influencing neural progenitor cell behavior. (32:00) Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Dr. Margaret Goodell, a leader in regenerative medicine and director at Baylor College, shares her groundbreaking research on hematopoietic stem cells (HSCs) and aging. She discusses her discovery of a unique side population of HSCs and explores the implications of DNMT3A mutations. The conversation dives into clonal hematopoiesis and its relationship with cardiovascular diseases. Goodell also highlights Houston's vibrant research environment, showcasing innovative advancements in stem cell therapies for conditions like Parkinson's and cardiac fibrosis.

Join Dr. Sarah Teichmann, a leading stem cell researcher at the Cambridge Stem Cell Institute, as she dives into the fascinating world of cell plasticity and the Human Cell Atlas project. Discover how she merges computational techniques with traditional biology and the importance of interdisciplinary teams in advancing research. She also highlights breakthroughs in stem cell therapy for diseases like Parkinson's and innovative organoid technologies. Her insights promise to illuminate the future of personalized medicine!

Professor Hank Greely, a leading bioethics expert at Stanford University, shares insights on his intriguing journey into the field of biomedical ethics. He delves into the ethical implications surrounding organoids and embryo models, raising questions about future reproductive technologies like gametogenesis and ectogenesis. Greely emphasizes the necessity of ethical frameworks as scientific advancements challenge traditional views on genetics and decision-making in reproduction, highlighting the balance between innovation and moral responsibility in modern medicine.