The Stem Cell Podcast

Guest: Dr. Connie Eaves is a Distinguished Scientist at the Terry Fox Laboratory at the British Columbia Cancer Agency and a Professor of Medical Genetics at the University of British Columbia. Her research focuses on leukemia and breast cancer and the normal tissues in which these diseases originate. Her pioneering research in basic blood stem cell biology led to a breakthrough in treatment for leukemia. Featured Products and Resources: Keep current with the latest in mammary cell research. Visit the Hematopoiesis Resource Center for videos, tips, and protocols to help with your research questions. The Stem Cell Science Round Up Brain Organoids with Optic Vesicles – Researchers generated human brain organoids with bilateral, light-sensitive optic vesicles. Clonal Mosaicism in Sperm – Scientists found that mosaic mutations, which can affect offspring and subsequent generations, arise in embryonic development and are present in the sperm of one in 15 men. Stem Cells in Skeletal Aging – Aging reduces the ability of skeletal stem cells to maintain a balance between bone formation and destruction. Maintaining HSC Fitness Ex Vivo – Heat shock factor 1 promotes HSC fitness and proteostasis in response to culture stress and aging. Photo Reference: Courtesy of Dr. Connie Eaves Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Ken Poss is the James B. Duke Professor of Cell Biology and Head of the Duke Regeneration Center at Duke University. His lab investigates the initial morphogenesis and injury-induced regeneration of several tissues in zebrafish. He is also President of the newly-founded International Society for Regenerative Biology. Featured Products and Resources: Using Social Media to Advance Your Scientific Career Activate, Expand, and Differentiate with Cytokines, Chemokines, and Growth Factors The Stem Cell Science Round Up A 4D Atlas of C. elegans Embryogenesis – Researchers generated a single-cell spatiotemporal atlas of transcription factors in C. elegans embryogenesis. Lysosomal Regulation of Stem Cell Fate – Scientists found that lysosomal activity regulates hematopoietic stem cell fate. Ductal and Mesenchymal Cells in Liver Regeneration – Researchers generated liver organoids and found that the ratio and number of contacts between ductal and mesenchymal cells regulate regeneration. Extending Life Span with VEGF – Researchers found reduced VEGF signaling in key organs in aged mice, and showed that VEGF-treated mice lived longer and had an extended health span. Photo Reference: Courtesy of Dr. Ken Poss Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Anthony Atala is the Founding Director of the Wake Forest Institute for Regenerative Medicine and the Chair of Urology at the Wake Forest School of Medicine. His team developed the first lab-grown organ to be implanted into a human and he currently oversees a team of over 400 researchers who are working to develop cell therapies and engineer replacement organs and tissues. Featured Products and Resources: STEMCELL Science News Survey Results: Pluripotent Stem Cell Research The Stem Cell Science Round Up Generating Gametes from PSCs – Researchers generated functional mouse oocytes from PSCs that could be fertilized and result in viable offspring. Dicer for Protection from RNA Viruses – An alternatively spliced isoform of the enzyme Dicer, called aviD, protects mammalian stem cells from RNA viruses through RNA interference. Mechanical Forces in Engineered Heart Tissues – Scientists generated engineered heart tissue systems with dynamic loading to model diseases such as arrhythmogenic cardiomyopathy. Drug Screening for Pulmonary Hypertension – Researchers used transcriptomics and iPSC-derived endothelial cells from pulmonary hypertension patients to identify a tyrosine kinase inhibitor that improved vascular function in a rat model. Photo Reference: Courtesy of Dr. Anthony Atala Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Bernie Siegel is an attorney and policy expert relating to stem cell research, regenerative medicine, and human cloning. He is the Executive Director of the Regenerative Medicine Foundation and the Founder of the World Stem Cell Summit. Featured Products and Resources: Keep current with the latest in cell therapy research. #StemCellfie Gallery The Stem Cell Science Round Up Airway-on-a-Chip – Researchers developed an airway-on-a-chip system using iPSCs to study ciliary function and model primary ciliary dyskinesia. Spatial Transcriptomics at Scale – Sci-Space is a new spatial transcriptomic method that can reveal spatially expressed genes across cell types on a large scale. Senescent Cells in Spinal Injuries– Researchers identified a difference in senescent profiles in zebrafish and mice after spinal cord injuries, and found that targeting senescent cells can promote recovery. A CRISPR Cure for Transthyretin Amyloidosis – A single dose of an in vivo gene-editing agent reduced transthyretin (TTR) levels in patients with TTR amyloidosis. Photo Reference: Courtesy of Bernie Siegel Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Aparna Bhaduri is an Assistant Professor of Biological Chemistry at the David Geffen School of Medicine at UCLA. Her lab studies how the human brain is created, with billions of cells spanning hundreds or thousands of cell types. They also explore how the cell building blocks of development can reappear later in life in brain cancers such as glioblastoma. Featured Products and Resources: Access resources for your neuroscience research. Learn about the STEMdiff™ Cerebral Organoid Kit from STEMCELL Technologies. The Stem Cell Science Round Up Hair Thinning in Obesity – Researchers found that obesity-induced stress depletes hair follicle stem cells in mice. Tracking Keratinocyte Stem Cells – Scientists used deep learning to track the motion of individual keratinocytes and keratinocyte stem cells, allowing them to identify the stem cells in a mixed population and study how culture conditions affect dynamics. Flipping a Switch in Heart Failure – Researchers identified a transcriptional switch that controls the activation of fibroblasts, and could be used to prevent fibrosis in the heart and other organs. Mapping Mouse Brain Development – Scientists used single cell sequencing to generate a comprehensive atlas of the developing mouse neocortex. Photo Reference: Courtesy of Dr. Aparna Bhaduri Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Intro: In June 2021, we attended the International Society for Stem Cell Research (ISSCR) virtual annual meeting, and recorded daily video episodes discussing highlights of the previous 24 hours. Here is the last of five special episodes from the meeting featuring Dr. Nicolas Rivron from the Institute of Molecular Biotechnology (IMBA) at the Austrian Academy of Sciences, who presented during the Plenary IV: Self-Organization of Developmental Processes session. Guest: Dr. Nicolas Rivron is a Group Leader at IMBA. The Rivron group recreates embryonic development using mammalian stem cells in a dish to better understand the encoded principles of self-organization. They observe both blastocysts and blastoids to study how self-organization contributes to multicellular patterning and cellular decision making. They address these questions using high throughput microsystems, single cell genomics, single cell high-content imaging, and synthetic biology. We discuss his talk and his thoughts on the meeting. Featured Products and Resources: View the COREdinates Focus Session for best practices and new tools for gene editing PSCs Visit STEMCELL’s Virtual Conference Exhibition <span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"></span> Photo Reference: Courtesy of Dr. Nicolas Rivron Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Intro: In June 2021, we attended the International Society for Stem Cell Research (ISSCR) virtual annual meeting, and recorded daily video episodes discussing highlights of the previous 24 hours. Here is the fourth of five special episodes from the meeting, featuring Dr. Sheila Chari from Cell Stem Cell. Guest: Dr. Sheila Chari is Editor-in-Chief at Cell Stem Cell and Executive Editor at Cell Press. Her primary responsibilities are knowing and publishing the top stem cell discoveries, driving journal publishing strategy, and managing a global editorial staff.  We discuss her thoughts on the meeting. Featured Products and Resources: View STEMCELL’s Virtual Conference Exhibition Reduce risk and obtain high-quality cells with TeSR™-AOF <span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"></span><span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"></span> Photo Reference: Courtesy of Dr. Sheila Chari Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Intro: In June 2021, we attended the International Society for Stem Cell Research (ISSCR) virtual annual meeting, and recorded daily video episodes discussing highlights of the previous 24 hours. Here is the third of five special episodes from the meeting featuring Dr. Shahin Rafii from Weill Cornell Medical College. Guest: Dr. Shahin Rafii is a Professor of Reproductive Medicine and the Arthur B. Belfer Professor in Genetic Medicine at Weill Cornell Medical College, as well as Director of the Ansary Stem Cell Institute. His research focuses on stem cell biology and angiogenesis. We discuss his research and thoughts on the meeting. Featured Products and Resources: View the schedule for STEMCELL’s Innovation Showcases Generate, expand, and differentiate human liver organoids using the HepatiCult™ Organoid Kit Photo Reference: Courtesy of Dr. Shahin Rafii Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Intro: In June 2021, we attended the International Society for Stem Cell Research (ISSCR) virtual annual meeting, and recorded daily video episodes discussing highlights of the previous 24 hours. Here is the second of five special episodes from the meeting featuring Dr. Madeline Lancaster from the Medical Research Council (MRC) Laboratory of Molecular Biology, who was honored with the Dr. Susan Lim Award for Outstanding Young Investigator Lecture at the meeting. Guest: Dr. Madeline Lancaster is a Group Leader in the Cell Biology Division at the MRC Laboratory of Molecular Biology at the University of Cambridge. Her lab studies the biological processes of human brain evolution using cerebral brain organoids as a model. We discuss her award and her thoughts on the meeting. Featured Products and Resources: View the schedule for STEMCELL’s Innovation Showcases  Learn about neural organoids at STEMCELL’s Neural Organoid Hub Photo Reference: Courtesy of Dr. Madeline Lancaster Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Intro: In June 2021, we attended the International Society for Stem Cell Research (ISSCR) virtual annual meeting, and recorded daily video episodes discussing highlights of the previous 24 hours. Here is the first of five special episodes from the meeting featuring Dr. Chuck Murry from the University of Washington, who presented during the Presidential Symposium: What’s in a Germ Layer session on the first day of the meeting. Guest: Dr. Chuck Murry is a Professor of Laboratory Medicine & Pathology, Bioengineering, and Medicine & Cardiology at the University of Washington, as well as Director of the Institute for Stem Cell Regenerative Medicine and the UW Medicine Heart Regeneration Program and Co-Director of the UW Center for Cardiovascular Biology. His research focuses on stem cell biology, with an emphasis on understanding the differentiation of the human cardiovascular system and using these cells to study disease and regenerate damaged tissues. We discuss his talk at the Presidential Symposium and his thoughts on the meeting. Featured Products and Resources: View the schedule for STEMCELL’s Innovation Showcases Visit STEMCELL’s Virtual Conference Exhibition <span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"></span><span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"></span><span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"></span> Photo Reference: Courtesy of Dr. Chuck Murry Subscribe to our newsletter! Never miss updates about new episodes. Subscribe