BBC Inside Science

More than 5,000 years of heavy agricultural labour by women can be read from the bones found in ancient cemeteries from the Neolithic to Iron Age times. Cambridge University anthropologist Alison Macintosh compared the arm bone dimensions and strength of women from these times with those of modern female athletes such as runners to rowers. Her conclusion is that average upper body strength of women through the Neolithic to the Iron age times exceeded that of today's semi-elite female rowers.A laboratory at the Scripps Research Institute have created a semi-synthetic bacterium with two new man-made genetic letters in its DNA, in addition to the natural four A, G, T and C. What's more, the engineered microbe can use its enhanced genetic alphabet to build synthetic amino acids into the proteins it makes. Chemist Floyd Romesberg talks to Adam Rutherford about what we can learn from his team's extraordinary feat of synthetic biotechnology, what we might gain from it and why, in his opinion, we've no need to be worried.Adam deals with some of your correspondence on axolotls by talking to laboratory salamander breeder Randal Voss at the University of Kentucky. He also notes listeners' comparisons of the recent visit by interstellar asteroid Oumuamua with the alien vessel in Arthur C Clarke's 'Rendezvous with Rama'.Cosmologist and AI researcher Max Tegmark visits BBC Inside Science to discuss the possibility of artificial intelligence machines with super-intelligence and how humanity should be preparing for their advent.Producer: Andrew Luck-Baker.

On 19th October, a mysterious object sped through our solar system. It was first spotted by astronomers with a telescope in Hawaii. Its trajectory and speed told of its interstellar origins. It is the first body to be detected from outside our solar system. Scientists are now publishing their papers on the enigmatic visitor. They estimate that it was about 400 metres long and bizarrely elongated in shape. Adam Rutherford talks to astronomer Alan Fitzsimmons of Queens University in Belfast. Twenty years ago, geneticist Svante Paabo began a revolution in human evolution science when he extracted fragments of DNA from the 40,000 year old bone of a Neanderthal. Among other first, he went onto sequence the entire genome sequence of Homo Neanderthalenisis. Professor Paabo was in the UK this week at a conference on DNA and human evolution at the Wellcome Genome Campus to mark the anniversary. He tells Adam about one of the new directions of research for him now.What does the future hold for synthetic biology? Who will be the practitioners of this fast-growing branch of bioengineering and what will be its impact on the world - for good and possibly ill? Experts in the field have just published a horizon-scanning report in the journal eLife. One of its authors, Jenny Molloy of the University of Cambridge, talks to Adam about the nascent democratisation of the discipline and where this might lead the field and society.The paradoxical plight of the axolotl: popular aquarium pet, laboratory animal and critically endangered species in the wild. This species of salamander is a wonder of nature. It's the amphibian that never grows out of its larval stage yet it's able to reproduce. Most remarkable is its ability to regrow limbs, which is of great potential interest to researchers developing regenerative medicine. There are many thousands of axolotls in labs and homes around the world. But in the wild, in their native Mexico, they are on the very edge of extinction. Inside Science talks to conservation biologist Richard Griffiths of the University of Kent and axolotl researcher Tatiana Sandoval Guzman of the Technical University in Dresden, Germany.Producer: Andrew Luck-Baker.

What might the length of the day have to do with the likelihood of destructive earthquakes around the world? According to Professors Rebecca Bendick and Roger Bilham, there's a correlation between changes in the rate at which the Earth rotates and the incidence of earthquakes of Magnitude 7 and above. The rotation speed of the planet increases and decreases over periods of years and decades. From their research, the earth scientists say that there's an substantial increase in the number of powerful earthquakes around the world five years after the Earth attains a peak in its spin speed and enters a period of slow down. The difference in day length is tiny but it is enough, say the researchers, to trigger already stressed faults in the crust to move sooner than later.In the year that the Soviet Union launched Sputnik into orbit, the UK launched its own rocket into the Space Race. 1957 saw the launch of the first Skylark space rocket. Inside Science talks to two veterans of the Skylark programme - Professors John Zarnecki and Ken Pounds - who cut their space research teeth with some of the 440 launches. The Science Museum in London is staging a Skylark exhibition in celebration.Francis Galton was one of the UK's most influential 19th century scientists and laid important methodological foundations for genetics and other fields of science today. But he was also a racist and leading proponent of eugenics. Adam discusses Galton's legacy with historian Subhadra Das of University College London and clinical geneticist Han Brunner of the Maastricht University Medical Centre in the Netherlands. Both guests attended a meeting of the Galton Institute in London which brought together researchers of many disciplines to discuss the bad and the good in Francis Galton's legacy.Producer: Andrew Luck-Baker.

Researchers in Italy and Germany have saved the life of a boy with a life threatening genetic skin disease, using a combination of stem cell and gene therapy. 7 year old Hassan had lost 60% of his protective epidermis because of the condition, junctional epidermolysis bullosa. The severe blistering and consequent bacterial infections put his life in imminent danger. In a final attempt to save him, the scientists took a small area of unblistered epidermis from his body, separated the constituent skin cells and then engineered them with a normal version of the gene that was malfunctioning in Hassan's body. Sheets of healthy epidermis of an area of about one square metre were then grown in culture, and then grafted onto 80% of his body. Hassan is now living a normal life, back at school, playing football. Lead researcher Michele de Luca describes the remarkable recovery and Fiona Watt, director of the Centre for Stem Cell and Regenerative Medicine at Kings College London, explains how the procedure worked.Scientists at the University of York are investigating medieval livestock farming through the study of the 1,000 year old York Gospels manuscript: not by reading it but by extracting proteins and DNA from its animal skin parchment pages. Inside Science listener and Middle Eastern archaeologist Melissa Sharp takes the programme to task for suggesting that anyone can now use publically available sonar and satellite data to search for shipwrecks and other archaeological sites. It opens up the world's ancient and not so ancient heritage to looters, she says. Since the University of Cambridge made Stephen Hawkings 1966 PhD thesis free to view and download last month, more than a million people have at least looked at it. Adam Rutherford talks to cosmologist Andrew Pontzen, biologist Matthew Cobb and neuroscientist Sophie Scott about the record-breaking thesis and asks whose first research project they'd like to download.Producer: Andrew Luck-Baker

Adam Rutherford talks to researchers on a major global study that aimed to quantify how climate change has already damaged the health of millions of people. Hugh Montgomery is the co-chair of the Lancet Countdown report and says that climate change is the largest single threat to global health. Climate scientist Peter Cox talks about his stark findings on the increase in the number of vulnerable people exposed to heat waves between now and the turn of the century.We hear anecdotes and concerns from listeners following our item last week on the catastrophic decline in flying insects in the last quarter century and the disappearance of moth snow storms.What can the social lives and brains of whales and dolphins tell us about the evolution of our species cognitive capacities and white matter? Adam talks to Susanne Shultz of the University of Manchester.Everyone's favourite indoor firework, the Pharoah's Serpent, is under scientific scrutiny from chemists Tom Miller and Andrea Sella at University College London.

The total biomass of flying insects in the environment has decreased by 75% in the last quarter of a century. That's the conclusion of research published at the end of last week in the journal PLOS One. The discovery, made in Germany, has shocked many, but should we in the UK be worried too? The answer is yes, according to Adam Rutherford's guests Dave Goulson, professor of biology at the University of Sussex, and Michael McCarthy, environmental journalist and author of 'The Moth Snow Storm.'The speed and ease of precise infection diagnosis could be transformed by synthetic biologists at Imperial College, London. Paul Freemont tells Adam about a simple DNA biosensor that turns green in the presence of a pneumonia-causing bacterium that is a particular problem for people with Cystic Fibrosis. He adds that the technology is adaptable to any kind of bacteria and may also aid efforts to curb the spread of antibiotic resistance.When dogs know you are looking at them, they ramp up the expressiveness of their faces. Marnie Chesterton visits the Dog Cognition Centre at the University of Portsmouth to talk to the researchers who made this discovery, and to meet Jimmy the Staffy.Palaeontologists at the University of Bristol have figured out the colour patterning on a dinosaur that lived 120 million years ago. Sinosauropteryx was a small feathered dinosaur. Two spectacular fossils of it were found in northeast China. The specimens are so well preserved that remnants of pigment remain in the feathers. This allows Jakob Vinter and colleagues to see that Sinosauropteryx was reddish brown in colour, with light stripes on its tail, light and dark counter-shading on its body and a dashing bandit-style face mask.Producer: Andrew Luck-Baker.

Adam Rutherford talks to astrophysicists about the astronomical discovery of the year, if not the last couple of decades: the collision of two neutron stars and the cosmic gold-forging aftermath. The discovery of this long-hypothesized event on 17th August came from the much awaited marriage of the capabilities of the gravitational wave detectors LIGO and Virgo with those of ground-based and space-based telescopes. Samaya Nissanke of Radboud University, Sheila Rowan of the University of Glasgow and Nial Tanvir of the University of Leicester take Inside Science through the story.What made the infamous 1883 eruption of Krakatoa so devastating? Roland Pease meets the earth scientists trying to answer the question by recreating in the lab the conditions under the volcano prior to the eruption.Following a temperature-related faux pas by Adam in the last episode, Michael de Podesta of the National Physical Laboratory explains the difference between Celsius and Centigrade.Producer: Andrew Luck-Baker.

Gareth Mitchell talks to Gillian Foulger of Durham University about HiQuake, the world's largest database of human-induced earthquakes. Professor Foulger and her colleagues have so far compiled close to 750 seismic events for which there are reasonable cases to be made for anthropogenic triggers. Triggers include mining operations, fossil fuel extraction, reservoir filling, skyscraper construction and tunnelling. Among the surprises is the fact that the US state of Oklahoma is more seismically active than California because of quakes and tremors set off by the local oil and gas industry. The theory of plate tectonics is 50 years old. It's as fundamental to understanding the Earth as evolution by natural selection is to understanding life. Roland Pease meets geologists such as Dan McKenzie, John Dewey and Xavier Le Pichon who played key roles in proving the hypothesis in the late 1960s.The United States has removed more than half of its diplomats from its embassy in Havana, Cuba. A signficant number of staff have complained of ailments such as hearing loss, dizziness, headaches and nausea, and there has been speculation that some kind of sonic or acoustic weapon might be responsible. Trevor Cox, professor of acoustic engineering at the University of Salford, discusses the likelihood with Gareth.Stanford University's Tom Mullaney is the author of 'The Chinese Typewriter: A History'. He talks to Gareth about the great engineering and linguistic challenge in the 19th and 20th centuries of getting the Chinese language onto a table top machine. The survival of the ancient language or China's entry into the modern world depended on the success of numerous inventors. In fact one consequence was the development of predictive text in the Chinese IT world long before it appeared in the West.Note: In the podcast version of this programme, there is an additional item on new research on the role of the world's botanical gardens in global plant conservation. One of the scientists involved, Dr Paul Smith of Botanical Gardens Conservation International, tells Gareth that there's good news about these institutions' contributions and there are areas where there is room for improvement.Producer: Andrew Luck-Baker

The gravitational waves produced by two massive black holes colliding have for the first time been detected by three gravitational wave detectors. Professor Sheila Rowan of the University of Glasgow explains the importance of this new three way observation.The World Health organisation reports that there are too few new candidate antibiotics in the development pipelines to replace those becoming obsolete through the rapid spread of antibiotic resistance. Professor Willem van Shaik of the University of Birmingham and pharma-biotech analyst Dr Jack Scannell discuss where the problems and solutions might lie.Could bacteria recycle all of our waste? Waste disposal is a growing concern as nations run out of space and ecosystems are increasingly polluted. Microorganisms may hold the key for turning household waste into biodegradable plastic and perhaps one day even into food and basic chemical feedstocks. Hans Vesterhoff, Professor of Systems Biology at Amsterdam University is developing microbial networks with the aim of converting all carbon-based waste into useful or edible stuff.AI and Opera: Prof Luc Steels, an AI and language researcher at the Institute for Advanced Studies of Catalonia is also a composer. He has just had his new opera premiered. With a libretto written by a neuropsychiatrist colleague, the opera 'Fausto' is a re-telling of the Faust story. It explores the dangers and flawed thinking of silicon-based transhumanism. In the opera, the Faust character is a social media-obsessed hipster and Mephistopheles is a malevolent AI in the cloud. In a twist on the original, Fausto trades his body rather than his soul so that he can be uploaded and reunited with his lover in the cloud.

After last week's Inside Science's edition devoted to Cassini ended, the Cassini spaceship plunged into the atmosphere of Saturn, and became part of the planet it studied. But the project lives on, as the data and photos generated by Cassini right up until contact was lost will be studied and scrutinised for years to come. Linda Spilker is the Project Scientist for the Cassini mission. Adam Rutherford spoke to her to find out what was captured in the last few moments of Cassini's closest and fatal encounter with the ringed planet. The House of Commons has announced its Science and Technology Select Committee - the body of MPs that holds the Government to account on scientific matters, and offers advice on scientific issues of the day. Some controversy has followed, concerning the scientific credentials and the gender imbalance of the committee make-up so far. Norman Lamb, MP for North Norfolk was elected chair of the committee, and he came into the Inside Science studio to discuss the committee selection and its future ambitions.This week was the 60th anniversary of one of the greatest conceptual leaps in all biology, made by Crick at a lecture at University College London. Matthew Cobb, biologist and historian from Manchester University, who's written a new account of the lecture, discusses its fundamental significance.It has long been suggested that there's something about the acoustics of a cave that correlates with the location of motifs and sometimes paintings on the walls.Bruno Fazenda is an acoustic scientist at the University of Salford, and reveals how he went into the caves to conduct the first methodical study of this theory by listening to the past.