Breaking Health

On this week’s installment of Breaking Health, Host Steve Krupa – CEO of the Psilos Group – dives into the intriguing story behind SolveBio, a company working to disrupt precision medicine.In this interview, Mark Kaganovich, PhD, CEO, and co-founder, discusses the benefits of SolveBio’s innovative data layer – called the “Genomic Intelligence Platform” – aimed at enabling pharma, biotech, and diagnostic organizations to effectively interact with genomic information.Founded in 2013 by graduate school classmates David Caplan, David Gross, and Kaganovich, SolveBio recognizes that isolated DNA sequencing technology has become increasingly essential in medicine and health care. But the process lacks accessible reference data that compares and cross references results from similar clinical trials, studies, and cases that may help decided company strategy or patient care. Kaganovich says the lack of context in genomics studies can sometimes be “mind boggling.”“This hasn’t really fully played out yet, but you’ll have people that make life-altering decisions based on a diagnostic report, and that report, where is the reference data for that? How do you know if you have a pathogenic variance or a benign variance?” Kaganovich asks. “It comes from some reference data set somewhere that probably some grad student contributed to some FTP site, and that kind of sat there. And then it was parsed out by a bioinformatician. It was normalized and some kind of quality control was done. But in the end, it comes from research often, or people don’t even know where it comes from. And to me, that’s kind of scary.”Where is SolveBio now? Dive with us into the episode here to learn in more detail about what the wider applications to SolveBio's mission could mean for health care tech and population care, and how its in-depth knowledge hub has already helped well-known customers.

Circulation co-founder and CEO Robin Heffernan explains how her start-up is working with the transportation giant to make it easier for patients to see a doctor.

Breaking Health Host Steve Krupa hears some exciting news from Optum’s Michael Weintraub and talks Analytics with Mudit Garg, founder and CEO of analyticsMD.

CEO Dan Burton, receiving the DHIS Innovator Award on behalf of the data warehouse company, speaks to strengths and values that have driven the company’s success.

Inspired by the sad tale of one patient, Kim founded One Caring Team to create a way to keep patients better connected through Virtual Reality.

Norwest Venture Partners’ Robert Mittendorff, MD, and host Steve Krupa discuss the “proof points” that demonstrate how technology is beginning to change how health care is delivered.

IORA’s co-founder and CEO Rushika Fernandopulle, MD, has spent the past decade trying to improve primary care. Hear how IORA Health is delivering on that long-time pursuit.

Health Catalyst CEO Dan Burton will be in Boston on Nov. 2 to receive the Digital Healthcare Innovator Award on behalf of the analytics company. Listen to the company’s winning philosophy in one of our earlier podcasts.

Oren Frank knows therapy saved his marriage. He and his wife, Roni, founded talkspace to make therapy an accessible, approachable and affordable option to everyone who could benefit.

Host Steve Krupa of the Psilos Group interviews Bill Geary, general partner of Flare Capital Partners, about his new firm, opportunities in health care, and the opportunities that inspired this year’s agenda.