Modern Healthspan

Description Hi all, apologies for the erratic release schedule recently. We have now changed the way that we release interviews on our YouTube channel and from now on will post the whole interview in a single video. The podcasts will follow the same pattern. This will mean that we have fewer, though longer podcasts. I hope that this works for you all. Thanks Richard Dr Keirstead talks about his work with stem cells and using the factors that young stem cells secrete to rejuvenate the immune system which then has systemic effects across the whole body. Dr Keirstead's therapy is currently in phase 1/2a human trials. Some links are affiliate links so we will earn a commission when they are used to purchase products. 🌐Links in this Interview Immunis Website https://immunisbiomedical.com/ The two papers published on preclinical trials of Immuna. Both are open access Stem cell secretome treatment improves whole-body metabolism, reduces adiposity, and promotes skeletal muscle function in aged mice https://onlinelibrary.wiley.com/doi/10.1111/acel.14144 Reversal of deficits in aged skeletal muscle during disuse and recovery in response to treatment with a secrotome product derived from partially differentiated human pluripotent stem cells https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602548/ Renue by Science all 10% discount with code MHS https://renuebyscience.com/ 10% off DoNotAge all products with discount code MHS https://donotage.org/products/

Hi all, apologies for the erratic release schedule recently. We have now changed the way that we release interviews on our YouTube channel and from now on will post the whole interview in a single video. The podcasts will follow the same pattern. This will mean that we have fewer, though longer podcasts. I hope that this works for you all. Thanks Richard Dr. Bryan was the first to describe nitrite and nitrate as indispensable nutrients required for optimal cardiovascular health. He was the first to demonstrate and discover an endocrine function of nitric oxide via the formation of S-nitrosoglutathione and inorganic nitrite. Through the drug discovery program in natural product chemistry, Dr. Bryan discovered unique compositions of matter than can be used to safely and effectively generate and restore nitric oxide in humans. This technology is now validated in six published clinical trials. He is also a successful entrepreneur who has commercialized his nitric oxide technology through the formation of Human, to the Power of N, Inc (formerly Neogenis Labs) where he is a Founder and inventor. Dr. Bryan has been involved in nitric oxide research for the past 18 years and has made many seminal discoveries in the field. These discoveries and findings have transformed the development of safe and effective functional bioactive natural products in the treatment and prevention of human disease and may provide the basis for new preventive or therapeutic strategies in many chronic diseases. Dr. Bryan has published a number of highly cited papers and authored or edited 5 books. He is an international leader in molecular medicine and nitric oxide biochemistry. Dr Bryan talks about why nitric oxide is so essential to our health and longevity. It is well known as a vasodilator which helps with CVD risk but it also impacts dementia and metabolic syndrome. 🌐Links in this interview Dr Nathan's Website https://drnathansbryan.com/ Bryan Therapeutics Inc: https://www.bryantherapeutics.com/ n1o1 website https://n1o1.com/ YouTube Channel https://www.youtube.com/channel/UCtftGy8e0r9DO8ActcyGi4w n1o1 Nitric Oxide 10% discount with code Modern https://tinyurl.com/3esakm4s n1o1 Nitric Oxide Lozenges https://tinyurl.com/yh4rrtht Age-Defiance Face Cream https://tinyurl.com/4zr959zh N.O.Beetz https://tinyurl.com/48cujze4 Pure Clean Performance: 15% discount code Modernhealth15 http://tinyurl.com/msspanpw Nitric oxide strips https://tinyurl.com/4tzmjazp Pure Clean Beets https://tinyurl.com/bdfhfanw Renue by Science all 10% discount with code MHS https://renuebyscience.com/ 10% off DoNotAge all products with discount code MHS https://donotage.org/products/

Here Dr Reis talks about what causes aging of the skin, and UVB is one of the main causes and what her longevity protocol looks like. Dr. Carolina Reis is the co-found and CEO of OneSkin Technologies. She holds a biochemistry degree and a Ph.D. focused on stem cell and tissue engineering. After more than 10 years of developing science in academia, she is thrilled to translate basic science into products that will extend our healthspan. As a founder of OneSkin, she and the team have been working to develop the first anti-senescence topical product designed to promote skin health from within. Dr. Reis is an alumnus of IndieBio, the world's largest seed biotech accelerator. She has moved from Latin America to Silicon Valley 4 years ago to found OneSkin and has been actively engaged in the longevity ecosystem in the Bay Area. 🌐Links in this episode OneSkin's website https://www.oneskin.co/ OneSkin 15% Discount: Code MODERN https://tinyurl.com/3t6tevj8 Related publications: https://www.oneskin.co/pages/publications Renue by Science all 10% discount with code MHS https://renuebyscience.com/ 10% off DoNotAge all products with discount code MHS https://donotage.org/products/

Here Dr Reis talks about some of the customer feedback that they have received. The feedback is available at the bottom of the product pages on the OneSkin website. Dr. Carolina Reis is the co-found and CEO of OneSkin Technologies. She holds a biochemistry degree and a Ph.D. focused on stem cell and tissue engineering. After more than 10 years of developing science in academia, she is thrilled to translate basic science into products that will extend our healthspan. As a founder of OneSkin, she and the team have been working to develop the first anti-senescence topical product designed to promote skin health from within. Dr. Reis is an alumnus of IndieBio, the world's largest seed biotech accelerator. She has moved from Latin America to Silicon Valley 4 years ago to found OneSkin and has been actively engaged in the longevity ecosystem in the Bay Area. 🌐Links in this episode OneSkin's website https://www.oneskin.co/ OneSkin 15% Discount: Code MODERN https://tinyurl.com/3t6tevj8 Related publications: https://www.oneskin.co/pages/publications Renue by Science all 10% discount with code MHS https://renuebyscience.com/ 10% off DoNotAge all products with discount code MHS https://donotage.org/products/

Here Dr Reis talks about the human as well as in vitro trials that her company is doing. The papers can be found on the OneSkin website (including the one that she refers to in the video as being published in the next week) Dr. Carolina Reis is the co-found and CEO of OneSkin Technologies. She holds a biochemistry degree and a Ph.D. focused on stem cell and tissue engineering. After more than 10 years of developing science in academia, she is thrilled to translate basic science into products that will extend our healthspan. As a founder of OneSkin, she and the team have been working to develop the first anti-senescence topical product designed to promote skin health from within. Dr. Reis is an alumnus of IndieBio, the world's largest seed biotech accelerator. She has moved from Latin America to Silicon Valley 4 years ago to found OneSkin and has been actively engaged in the longevity ecosystem in the Bay Area. 🌐Links in this episode OneSkin's website https://www.oneskin.co/ OneSkin 15% Discount: Code MODERN https://tinyurl.com/3t6tevj8 Related publications: https://www.oneskin.co/pages/publications Renue by Science all 10% discount with code MHS https://renuebyscience.com/ 10% off DoNotAge all products with discount code MHS https://donotage.org/products/

Here Dr Reis talks about the new series of products that the team at OneSkin have developed, including for body, eyes, sun protection and a cleanser. Dr. Carolina Reis is the co-found and CEO of OneSkin Technologies. She holds a biochemistry degree and a Ph.D. focused on stem cell and tissue engineering. After more than 10 years of developing science in academia, she is thrilled to translate basic science into products that will extend our healthspan. As a founder of OneSkin, she and the team have been working to develop the first anti-senescence topical product designed to promote skin health from within. Dr. Reis is an alumnus of IndieBio, the world's largest seed biotech accelerator. She has moved from Latin America to Silicon Valley 4 years ago to found OneSkin and has been actively engaged in the longevity ecosystem in the Bay Area. 🌐Links in this episode OneSkin's website https://www.oneskin.co/ OneSkin 15% Discount: Code MODERN https://tinyurl.com/3t6tevj8 Related publications: https://www.oneskin.co/pages/publications Renue by Science all 10% discount with code MHS https://renuebyscience.com/ 10% off DoNotAge all products with discount code MHS https://donotage.org/products/

Here Dr Reis talks about the development of OS-1 the peptide used in One Skins products, its senomorphic effects and other ingredients which are included in the One Skin product range. Dr. Carolina Reis is the co-found and CEO of OneSkin Technologies. She holds a biochemistry degree and a Ph.D. focused on stem cell and tissue engineering. After more than 10 years of developing science in academia, she is thrilled to translate basic science into products that will extend our healthspan. As a founder of OneSkin, she and the team have been working to develop the first anti-senescence topical product designed to promote skin health from within. Dr. Reis is an alumnus of IndieBio, the world's largest seed biotech accelerator. She has moved from Latin America to Silicon Valley 4 years ago to found OneSkin and has been actively engaged in the longevity ecosystem in the Bay Area. 🌐Links in this episode OneSkin's website https://www.oneskin.co/ OneSkin 15% Discount: Code MODERN https://tinyurl.com/3t6tevj8 Related publications: https://www.oneskin.co/pages/publications Renue by Science all 10% discount with code MHS https://renuebyscience.com/ 10% off DoNotAge all products with discount code MHS https://donotage.org/products/

Here Dr Trommelen talks about practical take aways from his study. How much protein should we eat, how often and what type is best. He also talks about his personal protocol. 🌐Links in this episode Dr Jorn Trommelen works as an Assistant Professor at the Department of Human Biology at Maastricht University. He is involved in research and education regarding the impact of exercise and nutrition on muscle mass and function. His research is part of the M3 research group and focuses on exercise and nutritional interventions to augment exercise performance and training adaptations in athletes. The anabolic response to protein ingestion during recovery from exercise has no upper limit in magnitude and duration in vivo in humans https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10772463/ Dr Trommelen's page https://www.nutritiontactics.com/ On twitter: https://twitter.com/JornTrommelen Facebook : https://www.facebook.com/nutritiontactics/ Instagram: https://www.instagram.com/nutritiontactics/ Renue by Science all 10% discount with code MHS https://renuebyscience.com/ 10% off DoNotAge all products with discount code MHS https://donotage.org/products/

Here Dr Trommelen talks about how the MPS continues for more than 12 hours, because of the presence of amino acids in the blood, however, mTOR does not appear to be activated and autophagy is not suppressed and provides his explanation for these findings. 🌐Links in this episode Dr Jorn Trommelen works as an Assistant Professor at the Department of Human Biology at Maastricht University. He is involved in research and education regarding the impact of exercise and nutrition on muscle mass and function. His research is part of the M3 research group and focuses on exercise and nutritional interventions to augment exercise performance and training adaptations in athletes. The anabolic response to protein ingestion during recovery from exercise has no upper limit in magnitude and duration in vivo in humans https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10772463/ Dr Trommelen's page https://www.nutritiontactics.com/ On twitter: https://twitter.com/JornTrommelen Facebook : https://www.facebook.com/nutritiontactics/ Instagram: https://www.instagram.com/nutritiontactics/ Renue by Science all 10% discount with code MHS https://renuebyscience.com/ 10% off DoNotAge all products with discount code MHS https://donotage.org/products/

Here Dr Trommelen talks about the amount of protein required to initiate MPS, what muscle break down is and how MPS is measured. Key take away: It is muscle synthesis which determines muscle mass much more then breakdown as breakdown remains in a very tight range. 🌐Links in this episode Dr Jorn Trommelen works as an Assistant Professor at the Department of Human Biology at Maastricht University. He is involved in research and education regarding the impact of exercise and nutrition on muscle mass and function. His research is part of the M3 research group and focuses on exercise and nutritional interventions to augment exercise performance and training adaptations in athletes. The anabolic response to protein ingestion during recovery from exercise has no upper limit in magnitude and duration in vivo in humans https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10772463/ Dr Trommelen's page https://www.nutritiontactics.com/ On twitter: https://twitter.com/JornTrommelen Facebook : https://www.facebook.com/nutritiontactics/ Instagram: https://www.instagram.com/nutritiontactics/ Renue by Science all 10% discount with code MHS https://renuebyscience.com/ 10% off DoNotAge all products with discount code MHS https://donotage.org/products/