Modern Healthspan

In this episode Professor Harries discusses the attitude of governments to aging, the most promising aging technologies and her personal protocol for staying healthy. Lorna Harries is Professor of Molecular Genetics at the University of Exeter College of Medicine and Health where she leads the RNA-mediated disease mechanisms group. Her group has interests in messenger RNA processing and epigenetic gene regulation in the context of ageing and chronic disease. She is a Co-Founder & the Chief Scientific Officer for SENISCA (www.senisca.com), a senotherapeutics company. Her team were the first to report dysregulation of alternative splicing as a new, and druggable, hallmark of ageing. With that, let me start the interview. Professor Harries site at University of Exeter https://medicine.exeter.ac.uk/people/profile/index.php?web_id=Lorna_Harries Senisca home page https://www.senisca.com/ If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan 15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15. Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/ 10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

In this episode Professor Harries discusses her company Senisca, her theory of aging and getting funded for aging research Lorna Harries is Professor of Molecular Genetics at the University of Exeter College of Medicine and Health where she leads the RNA-mediated disease mechanisms group. Her group has interests in messenger RNA processing and epigenetic gene regulation in the context of ageing and chronic disease. She is a Co-Founder & the Chief Scientific Officer for SENISCA (www.senisca.com), a senotherapeutics company. Her team were the first to report dysregulation of alternative splicing as a new, and druggable, hallmark of ageing. With that, let me start the interview. Professor Harries site at University of Exeter https://medicine.exeter.ac.uk/people/profile/index.php?web_id=Lorna_Harries Senisca home page https://www.senisca.com/ If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan 15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15. Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/ 10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

In this episode Professor Harries discusses how oligonucleotides can be used for as a very precise way to control gene expression. Lorna Harries is Professor of Molecular Genetics at the University of Exeter College of Medicine and Health where she leads the RNA-mediated disease mechanisms group. Her group has interests in messenger RNA processing and epigenetic gene regulation in the context of ageing and chronic disease. She is a Co-Founder & the Chief Scientific Officer for SENISCA (www.senisca.com), a senotherapeutics company. Her team were the first to report dysregulation of alternative splicing as a new, and druggable, hallmark of ageing. With that, let me start the interview. Professor Harries site at University of Exeter https://medicine.exeter.ac.uk/people/profile/index.php?web_id=Lorna_Harries Senisca home page https://www.senisca.com/ If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan 15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15. Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/ 10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

In this episode Professor Harries discuss how she and her team used resveralogs initially and later HS2 donors to change the regulation of splicing factors and in doing so, reverse cellular senescence. We also touch on what a therapy based on this might look like in the clinic. Lorna Harries is Professor of Molecular Genetics at the University of Exeter College of Medicine and Health where she leads the RNA-mediated disease mechanisms group. Her group has interests in messenger RNA processing and epigenetic gene regulation in the context of ageing and chronic disease. She is a Co-Founder & the Chief Scientific Officer for SENISCA (www.senisca.com), a senotherapeutics company. Her team were the first to report dysregulation of alternative splicing as a new, and druggable, hallmark of ageing. With that, let me start the interview. Professor Harries site at University of Exeter https://medicine.exeter.ac.uk/people/profile/index.php?web_id=Lorna_Harries Senisca home page https://www.senisca.com/ If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan 15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15. Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/ 10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

In this episode Professor Harries discuss whether RNA Splicing meets the criteria of a hallmark of aging. To qualify it should i) manifest during normal aging ii) its aggravation should accelerate aging and iii) it amelioration should slow or reverse aging. Prof Harries goes through each of these criteria with respect to RNA splicing. Lorna Harries is Professor of Molecular Genetics at the University of Exeter College of Medicine and Health where she leads the RNA-mediated disease mechanisms group. Her group has interests in messenger RNA processing and epigenetic gene regulation in the context of ageing and chronic disease. She is a Co-Founder & the Chief Scientific Officer for SENISCA (www.senisca.com), a senotherapeutics company. Her team were the first to report dysregulation of alternative splicing as a new, and druggable, hallmark of ageing. With that, let me start the interview. Professor Harries site at University of Exeter https://medicine.exeter.ac.uk/people/profile/index.php?web_id=Lorna_Harries Senisca home page https://www.senisca.com/ If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan 15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15. Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/ 10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

In this episode Professor Harries addresses some of the fundamental questions about RNA splicing and how it regulates gene expression Lorna Harries is Professor of Molecular Genetics at the University of Exeter College of Medicine and Health where she leads the RNA-mediated disease mechanisms group. Her group has interests in messenger RNA processing and epigenetic gene regulation in the context of ageing and chronic disease. She is a Co-Founder & the Chief Scientific Officer for SENISCA (www.senisca.com), a senotherapeutics company. Her team were the first to report dysregulation of alternative splicing as a new, and druggable, hallmark of ageing. With that, let me start the interview. Professor Harries site at University of Exeter https://medicine.exeter.ac.uk/people/profile/index.php?web_id=Lorna_Harries Senisca home page https://www.senisca.com/ If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan 15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15. Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/ 10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

In this video Professor Robbins discusses reprogramming using the Yamanaka Factors as the most promising technology in aging and its relationship to DNA damage. He also talks about his personal protocol for longevity. Dr. Robbins is a Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director of the Institute on the Biology of Aging and Metabolism (iBAM) at the University of Minnesota. He was part of a collaborative team that was the first to identify senotherapeutic compounds, able to reduce the senescent cell burden and extend healthspan and lifespan in mouse models that are now in more than 15 clinical trials. Professor Robbins' page at University of Minnesota https://robbins.umn.edu/dr-paul-robbins-phd Institute of the Biology of Aging and Metabolism If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan 15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15. Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/ 10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

In this video Professor Robbins discusses the work his lab is doing with Exosomes or EV (Extra-Cellular Vesicles) and how these can impact senescent cells by suppressing SASP as senomorphics Dr. Robbins is a Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director of the Institute on the Biology of Aging and Metabolism (iBAM) at the University of Minnesota. He was part of a collaborative team that was the first to identify senotherapeutic compounds, able to reduce the senescent cell burden and extend healthspan and lifespan in mouse models that are now in more than 15 clinical trials. Professor Robbins' page at University of Minnesota https://robbins.umn.edu/dr-paul-robbins-phd Institute of the Biology of Aging and Metabolism If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan 15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15. Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/ 10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

In this video Professor Robbins discusses the work his lab is doing, investigate what makes centenarians different at the genetic level and then to develop drugs which can mimic these differences. One of these differences is in SIRT6 and he talks about what they are doing to better understand this in collaboration with Prof Vera Gorbunova and colleagues at the Albert Einstein College of Medicine. Dr. Robbins is a Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director of the Institute on the Biology of Aging and Metabolism (iBAM) at the University of Minnesota. He was part of a collaborative team that was the first to identify senotherapeutic compounds, able to reduce the senescent cell burden and extend healthspan and lifespan in mouse models that are now in more than 15 clinical trials. Professor Robbins' page at University of Minnesota https://robbins.umn.edu/dr-paul-robbins-phd Institute of the Biology of Aging and Metabolism If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan 15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15. Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/ 10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

In this video Professor Robbins discusses the process by which his and other labs look for possible senolytics. He also talks about fisetin and why he chooses to take it Dr. Robbins is a Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director of the Institute on the Biology of Aging and Metabolism (iBAM) at the University of Minnesota. He was part of a collaborative team that was the first to identify senotherapeutic compounds, able to reduce the senescent cell burden and extend healthspan and lifespan in mouse models that are now in more than 15 clinical trials. Professor Robbins' page at University of Minnesota https://robbins.umn.edu/dr-paul-robbins-phd Institute of the Biology of Aging and Metabolism If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan 15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15. Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/ 10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/