Modern Healthspan

GLP-1 drugs likesemaglutide and ozempic have become household names but how much do we reallyunderstand about what they're doing inside the body? In this episode I sit downwith Dr. Mikhail Kolonin, Professor and Director of the Center for Metabolicand Degenerative Diseases at UTHealth Houston's McGovern Medical School, whoselab has spent years uncovering the deeper biology of these drugs.We go far beyondweight loss. Dr. Kolonin explains how GLP-1 drugs trigger IL-6 signaling in fattissue, activating a thermogenic program that converts metabolically inactivewhite fat into energy-burning brown fat and how in some patients this isaccompanied by upregulation of telomerase, a protein with profound implicationsfor mitochondrial health and aging. We also tackle the muscle loss questiondirectly, examining what the latest research reveals about why lean mass losson GLP-1s exceeds simple caloric restriction, and what can realistically bedone about it. 🌐Linksin this video Dr Kolonin's page https://gsbs.uth.edu/directory/profile?id=b816c8de-c9b0-40f0-873c-42fa69db82e9 Time-LineMitopure Urolithin A, 10% off Code MODERN https://tidd.ly/4bLCpguQitone (10%off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters PowderSeekingHealth supplements: 10% discount code Richard10https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrientshttps://crrnt.app/SEEK/EpM7paAOAX3 LifeAstaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comStemregen 15%discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Scienceall 10% discount with code MHS https://renuebyscience.com/  Nuchido Time+ 20% discount offirst purchase with code MODERN20 https://nuchido.com/MODERNIf you would like tosupport our channel please consider signing up on patreonhttps://patreon.com/ModernHealthspanYou can also find us onYouTube at https://www.youtube.com/c/modernhealthspan

Dr. Anurag Singh, Chief Scientific Officer at Timeline Nutrition joins Modern Healthspan for an in-depth conversation about urolithin A and the science of mitophagy, the cellular process that cleans out damaged mitochondria.We explore the clinical evidence from multiple human trials: the ATLAS trial showing 12% muscle strength gains and 10% VO2 max improvements in sedentary middle-aged adults, independent studies in elite athletes demonstrating enhanced recovery and performance, and the groundbreaking MitoImmune trial published in Nature Aging revealing 20% increases in immune cell mitochondria in just 28 days.Dr. Singh provides practical guidance on dosing (500mg vs 1000mg), timing, and who benefits most from supplementation. We discuss why only 30% of people can produce urolithin A naturally from foods like pomegranates and berries, and how direct supplementation overcomes this limitation.Looking ahead, we cover Timeline's Healthspan XPrize semi-finalist status, ongoing blood-brain barrier research setting the stage for brain health trials, and Dr. Singh's vision for combining mitophagy activation with emerging therapies like mitochondrial transplantation. He also shares why he believes mitochondrial dysfunction is "the mother of all hallmarks of aging."Whether you're interested in the science of healthy aging, considering urolithin A supplementation, or want to understand the future of longevity medicine, this comprehensive conversation provides the evidence and insights you need.Topics covered:• What urolithin A is and how mitophagy works• ATLAS trial results: muscle, endurance, and inflammation• MitoImmune trial: immune system rejuvenation• Practical supplementation guide• Brain health research and future directions• The role of mitochondrial health in aging🌐Links in this video Time-Line home page https://www.timeline.com/ ATLAS Trial: Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults https://pubmed.ncbi.nlm.nih.gov/35584623/ Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial https://www.nature.com/articles/s43587-025-00996-xTime-Line Mitopure Urolithin A, 10% off Code MODERN https://tidd.ly/4bLCpguQitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters PowderSeeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAOAX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comStemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERNIf you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspanYou can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Dr. Valter Longo explains how fasting-mimicking diets make cancer cells vulnerable to treatment while protecting healthy tissue, plus the clinical evidence, safety protocols, and why oncologists remain skeptical.Dr. Valter Longo, author of "Fasting Cancer," breaks down decades of research on using fasting-mimicking diets (FMD) alongside conventional cancer therapies. Cancer cannot be starved but it can be metabolically weakened by limiting resources which a the same time protects healthy cells. A process known as differential stress resistance. We cover: the mechanism behind why this works, clinical trial results in triple-negative breast cancer and other aggressive cancers, the surprising data on weight loss and cachexia, BMI cutoffs and safety protocols, how to approach your oncologist, prevention versus treatment applications, and the cutting-edge "escape pathway" research that could transform personalized cancer treatment. Dr Longo addresses the elephant in the room: why, despite promising results in both mouse models and human trials, this approach faces massive institutional and regulatory barriers to becoming standard of care. Practical, evidence-based information for patients, caregivers, and anyone interested in the intersection of nutrition and cancer biology.🌐Links in this video Create Cures Foundation https://createcures.org/ - Dr Longo organization in the US The Valter Longo Foundation https://www.fondazionevalterlongo.org/en/ - Dr Longo's organization in Italy and rest of the world Dr Longo's website https://valterlongo.com/ Facebook https://www.facebook.com/profvalterlongo/ Instagram https://www.instagram.com/prof_valterlongo/ Fasting Mimicking Diet company Prolon https://prolonlife.com/*Qitone* (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters PowderSeeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAOAX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comStemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERNIf you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspanYou can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Dr. Luigi Ferrucci reveals what 60 years of Baltimore Longitudinal Study data shows about aging, inflammation, mitochondria, and the biomarkers that predict your health trajectory.In this conversation, Dr. Luigi Ferrucci, Scientific Director of the National Institute on Aging and director of the Baltimore Longitudinal Study of Aging, shares insights from the longest-running scientific study of human aging.We discuss why measuring the pace of aging matters more than a single snapshot, how mitochondrial function drives the entire aging process, and why chronic inflammation may be a secondary response rather than a primary cause of aging. Dr. Ferrucci reveals which biomarkers should be in clinical use right now (including GDF-15), what the BLSA data shows about people who age successfully, and the specific lifestyle factors that add nine years of healthy life expectancy.This is essential viewing for anyone interested in longevity science, biological age testing, and evidence-based interventions to slow aging. Dr. Ferrucci brings decades of rigorous research to questions about what actually works and what we're still learning.🌐Links in this video Dr Ferrucci's page at the NIA https://irp.nih.gov/pi/luigi-ferrucciBaltimore Longitudinal Study of Aging main site https://www.nia.nih.gov/research/labs/blsaThe Baltimore Longitudinal Study of Aging (BLSA): A 50-Year-Long Journey and Plans for the Futurehttps://pmc.ncbi.nlm.nih.gov/articles/PMC5004590/#longevity #healthspan #aging*Qitone* (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters PowderSeeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAOAX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comStemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERNIf you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspanYou can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Dr. DanPardi explains why creatine supplementation may help preserve cognitivefunction during sleep deprivation, aging, and high mental demand, plus thespecific dosing strategies most people miss. In thisconversation, Dr. Dan Pardi breaks down the emerging science of creatine forbrain health. While creatine is famous for athletic performance, new researchshows it may help maintain cognitive function under stress, particularly duringsleep deprivation, travel, and aging. Dr. Pardi explains the mechanisms: howcreatine acts as an energy buffer in the brain, why it works best under fatigueor high demand, and which cognitive functions respond most consistently(working memory, processing speed, sustained attention). We cover practicaldosing strategies, including why 5 grams daily may not be enough for brainbenefits, the role of loading phases, and the specific high-dose protocolstudied for sleep deprivation. This isn't about cognitive enhancement; it'sabout preservation. If you're interested in maintaining brain performance asyou age, dealing with poor sleep, or supporting cognitive resilience, thisconversation offers actionable strategies backed by research. 🌐Linksin this video Qualia LifeSciences web page https://www.qualialife.com/Human OSwebsite https://humanos.me *Qitone*(10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters PowderSeekingHealth supplements: 10% discount code Richard10https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrientshttps://crrnt.app/SEEK/EpM7paAOAX3 LifeAstaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comStemregen 15%discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Scienceall 10% discount with code MHS https://renuebyscience.com/  Nuchido Time+ 20% discount offirst purchase with code MODERN20 https://nuchido.com/MODERNIf you would like tosupport our channel please consider signing up on patreonhttps://patreon.com/ModernHealthspanYou can also find us onYouTube at https://www.youtube.com/c/modernhealthspan

Dr. Allen Taylor spent 40 years at Tufts discovering how diet affects vision. Learn why high glycemic foods accelerate macular degeneration and cataracts—and what you can do to protect your eyes.Dr. Allen Taylor directed the Laboratory for Nutrition and Vision Research at Tufts University for four decades, pioneering groundbreaking discoveries about how nutrition impacts age-related eye diseases. In this comprehensive interview, he reveals how high glycemic diets create a "double jeopardy" in your eyes—damaging proteins while simultaneously destroying your cellular cleanup systems.Dr. Taylor explains the cellular mechanisms behind age-related macular degeneration (AMD) and cataracts, breaking down complex biochemistry into actionable insights. You'll learn about the epidemiological evidence linking Western diets to AMD risk, why blood sugar spikes matter even for non-diabetics, and how advanced glycation end products (AGEs) accumulate in retinal tissue.The conversation covers practical strategies including which antioxidants matter most (vitamin C, vitamin E, lutein), why omega-3 fatty acids support retinal health, and how switching from high to low glycemic foods could prevent 100,000 cases of blinding AMD annually. Dr. Taylor also discusses his current intervention trial testing whether people with early AMD can preserve vision through dietary changes.Key topics: macular degeneration, cataracts, glycemic index, nutrition and vision, eye health, aging, preventive medicine, antioxidants, drusen, photoreceptor health, retinal pigment epithelium, and practical dietary interventions for longevity🌐Links in this video Dr Taylor's page at Tufts https://facultyprofiles.tufts.edu/allen-taylor The review mentioned by Dr Taylor: Glycative stress as a cause of macular degeneration Full Version: https://tinyurl.com/bdp3u93f Summary Version: https://tinyurl.com/yj2zmx5n*Qitone* (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters PowderSeeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAOAX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comStemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERNIf you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspanYou can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Your ferritin test doesn't measure what you think. Dr. Douglas Kell explains iron dysregulation, dormant microbes, and his controversial theory about chronic diseaseDr. Douglas Kell, systems biologist at the University of Liverpool, presents his research on iron dysregulation and its potential role in chronic inflammatory diseases. In this conversation, he explains why ferritin in blood is actually a marker of cell death rather than iron storage, how free iron can trigger oxidative stress through the Fenton reaction, and his hypothesis about dormant bacteria and amyloidogenic microclots. We discuss practical interventions including what iron tests actually matter (transferrin saturation over ferritin), natural compounds like ergothioneine from mushrooms that showed dramatic protective effects in studies, and enzymes like nattokinase that may help address abnormal clotting. Dr. Kell also covers his work on pre-eclampsia, the connection between iron and neurodegenerative diseases, and why he views most chronic inflammatory diseases through a systems biology lens. While his full IDDM (Iron Dysregulation and Dormant Microbes) hypothesis remains contested, the practical information on iron management and oxidative stress provides actionable insights for healthy aging.🌐Links in this video Dr Kell's page at University of Liverpool https://www.liverpool.ac.uk/people/douglas-kell DBK Group's web page with all Dr Kell's publications https://dbkgroup.org/*Qitone* (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters PowderSeeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAOAX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comStemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERNIf you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspanYou can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Dr. Eric Plaisance explains how exogenous ketones may provide fasting benefits without dietary restriction - the hormetic effects of mimicking starvation while fed. Plus: ketone salts vs esters, his personal protocol, and why performance claims don't hold up.Dr. Eric Plaisance, Associate Professor at University of Alabama Birmingham, has spent over a decade studying exogenous ketone esters. His most intriguing finding? Ketones may allow us to "mimic a starvation environment when we're not starving" - potentially triggering the same hormetic benefits as fasting without dietary restriction. In this conversation, we explore the anti-inflammatory effects of ketones, the promising research in liver health and cancer, and the practical differences between ketone salts, esters, and MCT oil. Dr. Plaisance shares his personal ketone protocol (including why he takes them before workouts during time-restricted eating), optimal dosing strategies, and why the athletic performance marketing claims don't match the research. We also discuss who should actually consider ketone supplementation versus who should save their money. A grounded, evidence-based perspective on one of longevity's most debated supplements.🌐Links in this video Dr Plaisance's page at Alabama University https://scholars.uab.edu/2392-eric-plaisance*Qitone* (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters PowderSeeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAOAX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comStemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERNIf you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspanYou can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Dr. Mary Newport shares groundbreaking research analyzing cholesterol profiles across 40 years of studies, challenging conventional wisdom about saturated fat and heart health. We discuss her findings on MCT oil for brain health, the 288 caregiver reports showing cognitive improvements, and practical protocols for using coconut oil and ketones.Dr. Mary Newport, physician and Alzheimer's researcher, joins us to discuss her latest research that challenges decades of assumptions about coconut oil and saturated fat. In this interview, we explore: • Her comprehensive analysis of 26 studies spanning 40 years (984 lipid profiles) showing coconut oil's unexpected effects on cholesterol • The 288 caregiver reports documenting improvements in memory, cognition, and daily function • How medium-chain triglycerides (MCTs) may provide an alternative fuel source for aging brains • Practical protocols for incorporating coconut oil and MCT oil into your diet • The controversial history of dietary fat guidelines and the trans fat problem • Why the medical establishment has been slow to acknowledge ketone research Dr. Newport's work began with her husband Steve's dramatic response to coconut oil after his early-onset Alzheimer's diagnosis. Her research has since expanded to include hundreds of case reports and comprehensive lipid analysis.🌐Links in this video 🔗 Dr. Newport's website: https://coconutketones.com/ Coalition for Metabolic Health https://coalitionformetabolichealth.org/ Analysis of 26 Studies of the Impact of Coconut Oil on Lipid Parameters: Beyond Total and LDL Cholesterol https://www.mdpi.com/2072-6643/17/3/514 Ketogenic strategies for Alzheimer’s disease and other memory impairments: History, rationale, and 288 caregiver case reports https://esmed.org/MRA/mra/article/view/5316Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAOAX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comStemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERNIf you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspanYou can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

DESCRIPTIONLeading hairrestoration surgeon Dr. Alan Bauman reveals the science behind hair loss,graying, and the evidence-based treatments that actually work—from medicationsto regenerative therapies.Dr. Alan Baumanis a board-certified hair restoration physician who has treated over 30,000patients and performed 14,000+ hair transplants in his 28-year career. In thisconversation, we explore the biological mechanisms behind hair loss andgraying, why you can lose 50% of your hair density before noticing it, and thepractical interventions that work. We discuss theevidence for medications like minoxidil and finasteride, regenerative therapiesincluding PRP and exosomes, low-level laser therapy, and the role of lifestylefactors like nutrition, stress, and sleep. Dr. Bauman explains genetic testingfor hair loss predisposition, the truth about DHT-blocking shampoos, whetherhair coloring damages follicles, and when to consider surgical options. Key takeaway:"Time equals follicles"—early intervention is critical because oncehair follicles are damaged, reversal becomes increasingly difficult. Whetheryou're experiencing thinning or want to protect your hair long-term, thisepisode provides actionable, science-based strategies.🌐Links in this video Bauman Medical website https://www.baumanmedical.com/LinkedIn https://www.linkedin.com/in/alanjbauman/Instagram https://www.instagram.com/baumanmedical/Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAOAX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comStemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERNIf you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspanYou can also find us on YouTube at https://www.youtube.com/c/modernhealthspan