The Effective Statistician - in association with PSI

Interview with Frank Konietschke Click here to get to the episode homepage! Frank has something in common with Benjamin and myself - we all studied statistics in Göttingen and learned and researched in non-parametric statistics. Afterwards, we went into different paths. Whereas Benjamin started at a CRO and I joined large pharma organizations, Frank continued on the academic track. He recently became Professor at the famous Charitee in Berlin, where he’s still dedicating a lot of research to the field of non-parametric statistics. However, he’s not an ivory tower researcher but also applies these approaches in the medical research he’s taking part in. Learn about a whole universe of different approaches, which will help you overcome many limitations of the methods, which you’re using daily.

Interview with Necdet Gunsoy This episode is based on a presentation at PSI 2019. Necdet won The Effective Statistician Best Presenter award for the amazing delivery of the presentation. But not only the delivery was excellent - the content will help you a lot. Here's the abstract for the conference: Abstract: Practical aspects of subgroup detectionRecent years have seen the emergence of new methods for detecting subgroups with enhanced treatment effects and statisticians are now faced with an overwhelming choice of approaches to consider. Confusion around the potential advantages and disadvantages of different methods can often result in the implementation of an approach which is not appropriate for a particular research question. This talk will provide a practical guide to the design and conduct of subgroup detection analyses, providing points to consider for selecting an appropriate method based on the research objective, the context of the analysis, the outcomes, and the covariates under consideration. Two example case studies will be presented to illustrate the discussed considerations. Necdet and I will also discuss the following Do you have practical examples based on a given data set that leads to very different approaches?As a PSI awardee of best presentation in this year's conference, How do you approach presentations?What’s your key recommendation for giving a great presentation?

Why I started The Effective Statistician and what you can learn from it Click here to get to the homepage of the episode! It all started when I became a new supervisor and had my first direct reports and I thought I really needed to learn about supervisory skills but I have very limited time. I found out that podcasts really help a lot to learn while I commute to work - it's effective.In this podcast, you can learn a lot from the following: What are my learnings along the way?What are my struggles? What are the strategies I used?How I balanced work and family life?How the production team helped me?What the effective statistician means to me?

Replay from the PSI conference 2018 Click here to get to the homepage of the episode! Are you a sponsor who is seeking joint scientific advice from a regulatory agency and from an HTA body? If yes, this episode is for you. This presentation replicates the discussions which may go on during scientific advice. The example was in Respiratory. This roleplay is played by David Wright, Oliver Keene, Stephen Ruberg, and myself. The aim is to show a couple of discussion points and an interesting aspect that may come up with such discussions. A lively debate followed about the differing needs of Regulatory agencies vs HTA, with the patient voice often not taking centre stage. We will also be talking about the following: Estimand for pivotal trials 5062018 and 5062019 (identical trials)Specifically strategy for intercurrent events Listen to this episode and share it with others, who might learn from it! Resources Link to the video on demand side on the PSI homepage! Link to the slides for the introduction.

People who ask take the lead Click here to get to the homepage of the episode! People who ask take the lead You can lead as well. According to Forbes, best leaders lead with questions, not answers. Leading with questions works because really good questions have a direct impact on the brain. When we are challenged by a question that triggers an insight, neurons connect in new ways. This releases neurotransmitters that create the motivation to act. The net result is that the other person not only likes the idea, but they also want to do something with it. In today's episode, Benjamin and I will be talking about: How success looks likeHow to create a win-win situationHow to get the team involved in creating the goal or at least tune into building relationships with peopleHow to move backwards once you have the goal, and put action steps into place to drive the project forwardHow to drive things by one-on-one Listen to this interview and share it with others, who might learn from it!

If you think of yourself as your own organisation – can you make yourself outsourcing proof? Click here to get to the homepage of the episode! A lot of statisticians, especially in pharmaceutical companies but also CROs, fear outsourcing because it might make their job redundant. Think about: In this episode, Benjamin and I will be talking about these tips and tricks: Benjamin and I will be talking about these tips and tricks: What are the things, that are done better, faster and cheaper by others? Does your supervisor know about your value? Do you help him or her to understand this? – Listen to our episode on selling your achievements Would your business partners care, if you would be replaced by a statistician at a different company or maybe even by a statistician within your organisation? Would they even notice? Might they even be better off?

Interview with Kat Greenbrook Storytelling allows businesses to better understand insight. Data visualization is a great tool to help share, or tell a story, but relies on the story being written first. Improved data communication comes from combining good visualization with a well-written narrative. At storytelling with data, the goal is to rid the world of ineffective graphs and help people elegantly communicate with data. They aim to bring data to life and use it to tell a story to an audience, with a focus on simplicity and ease of interpretation. They believe everyone can inspire positive change through the stories they tell with data. There's a lot to learn to be a good data storyteller. Today, I’m talking with Kat about: What do you understand by storytelling with data?Why is it important?Which role should statisticians play?What skills do statisticians need for this?Where to learn these skills?

Click here to get to the homepage of the episode! There is an endless list of things that can go wrong.I'm pretty sure you have been in painful discussions about this.Have you felt a lot of frustrations on both ends? Benjamin works for the CRO and I work for the sponsor side. In this episode, we will be giving you a lot of insights on what to do and what not to do, and how to make collaboration between the sponsor and CRO successful. Specifically, Benjamin and I will be talking about: Have partnership on an equal levelCreate common expectations on qualityEstablish stable personal relationshipsHave low turn over ratesTransparency of processes is importantHave a fair paymentInvest in creating trustGood feedback habits Work towards CRO processes and SOPs Choose your vendor wisely - a good choice is half the success

“Data Driven Decision Making in Medical Research” Click here to get to the homepage of the episode! In this series of interviews with the speakers at the conference, we talked about different topics: Visualization softwareBenefit risks approachGlobal statistical test for multiple endpoint analysisEstimandsAE analysis using a volcano plot I also talked to Rachel Phillips at the PSI conference. She is an NIHR doctoral research fellow at Imperial College London. Please help her with her study. It will help all of us in the end and you can win something! This is a survey of clinical trial statisticians with experience of planning and performing final data analyses for pharmacological RCTs to explore their awareness of available statistical methods to flag adverse events as potential adverse drug reactions (ADRs) and identify any potential barriers to their use, as well as gain feedback on ideas for new statistical methods. They would like participants to provide their personal views. This study is being organised and sponsored by Imperial College London. This study is funded by the National Institute for Health Research (NIHR). The survey should take no longer than 10 minutes to complete and all participants will be entered into a prize draw to win a £50 Amazon voucher. The survey should take no longer than 10 minutes to complete and all participants will be entered into a prize draw to win a £50 Amazon voucher. If you are happy to participate in the survey, please follow the link below: https://www.surveymonkey.com/r/R5M2R83 Listen to this episode, to get more insights into what’s possible and to learn more about the conference!

Discussion between Benjamin and Alexander Do you agree that everybody makes mistakes?Have you had to deal with a mistake yourself, that you were really concerned about?Were you afraid about speaking with your supervisor or your team with it? We are all imperfect humans making mistakes. The questions are: how do we deal with them, what we can do about them, and what to do to minimize them. Processes are made to minimize mistakes and there different processes were set up to deal with mistakes and help you when mistakes occur.