HFA Cardio Talk

With Guillaume Baudry, University Hospital of Brabois, Nancy - France, and Marco Metra, University of Brescia - Italy. In this episode of the HFA Cardiotalk podcast, Guillaume Baudry interviews Marco Metra, the lead author of the recent HFA clinical consensus statement on worsening heart failure. They delve into the definition of worsening heart failure, its prognosis, prevention strategies, and both acute and long-term management of this condition. Related scientific paper: Worsening of chronic heart failure: definition, epidemiology, management and prevention. A clinical consensus statement by the Heart Failure Association of the European Society of Cardiology Risk of readmission and death after hospitalization for worsening heart failure: Role of post-discharge follow-up visits in a real-world study from the Grand Est Region of France Effect of Dapagliflozin on Worsening Heart Failure and Cardiovascular Death in Patients With Heart Failure With and Without Diabetes Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure Effect of Empagliflozin on the Clinical Stability of Patients With Heart Failure and a Reduced Ejection Fraction: The EMPEROR-Reduced Trial Safety, tolerability and efficacy of up-titration of guideline-directed medical therapies for acute heart failure (STRONG-HF): a multinational, open-label, randomised, trial Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction This 2024 HFA CardioTalk podcast serie is supported by Novartis in the form of an educational grant. The discussion has not been influenced in any way by its sponsor.

With Raja Ezman Faridz Bin Raja Shariff, Universiti Teknologi MARA, Selangor - Malaysia, and Kevin Damman, University Medical Centre Groningen - The Netherlands In this episode of the HFA Cardiotalk podcast, Ezman Shariff interviewed Kevin Damman – a key opinion leader in the field of cardiorenal interactions, to better understand the role natriuresis plays in the acute heart failure and what we have learnt from trials like PUSH-AHF and ENACT-HF, and the future direction of clinical trials in this field. This 2024 HFA CardioTalk podcast serie is supported by Novartis in the form of an educational grant. The discussion has not been influenced in any way by its sponsor.

Experts from around the world discuss late-breaking clinical trials on heart failure, including hypertonic saline, echo substudy, and PRAISE-HFpEF results. The podcast dives into the evolving landscape of AF ablation as a primary treatment for heart failure patients, exploring its advantages over traditional drug therapies and highlighting the potential benefits for improved patient outcomes.

With Jozine M. ter Maaten, University Medical Centre Groningen, Groningen - Netherlands, Bart A. Mulder, 2022-2024, University Medical Centre Groningen, Groningen - Netherlands & Giuseppe Boriani, Polyclinic Modena University Hospital, Modena -Italy. Atrial fibrillation and heart failure often co-exist and influence each other. Treatment of AF specifically in the setting of heart failure can be challenging. Recently, new data emerged regarding the potential role of AF ablation in heart failure patients. In this podcast we discuss these in a special episode with a strong representation also from the EHRA Young highlighting the importance of interdisciplinary decision making in these patients. Recommended readings from this episode: CASTLE HTx CASTLE AF CABANA results in heart failure patients This 2024 HFA CardioTalk podcast series is supported by Novartis in the form of an educational grant. The discussion has not been influenced in any way by its sponsor.

Cardiologist Cornelia Margineanu from Bucharest, Romania, and Professor Thomas Felix Luscher from London, UK, discuss the future of heart failure specialists. They cover topics such as the evolution of heart failure treatment, challenges faced by future specialists, mentorship, career development, and exciting opportunities in cardiology.

Experts Mateusz Sokolski and Amina Rakisheva discuss the possibility of reversing heart failure, exploring factors influencing ejection fraction improvement, recovery definitions, cardiomyopathy diagnostic criteria, reversible causes like Fabry disease, and regenerative medicine with stem cell therapies and genetic considerations.

With Alberto Esteban-Fernández. Severo Ochoa University Hospital, Madrid - Spain & John McMurray. BHF Glasgow Cardiovascular Research Centre, Glasgow - UK. We discuss the implementation of 2021 HF guidelines, the possibility of implementing foundational therapy in clinical practice, and difficulties and barriers. Also, we discuss future heart failure treatments in the coming years. Access the 2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. "This 2024 HFA CardioTalk podcast series is supported by Novartis in the form of an educational grant. The discussion has not been influenced in any way by its sponsor."

With Antonio Cannata, King's College London - UK and Folkert Asselbergs, Amsterdam University Medical Centre - Netherlands. In this episode of HFA CardioTalk Antonio Cannata interviews one of the pioneer in digital medicine and artificial intelligence in cardiovascular medicine, Prof Folkert Asselbergs. Several interesting insights were discussed on the present role of AI in Heart Failure and what the future holds. "This 2024 HFA CardioTalk podcast series is supported by Novartis in the form of an educational grant. The discussion has not been influenced in any way by its sponsor."

With Henrike Arfsten,Medical University of Vienna - Austria & Antoni Bayes-Genis, Heart Institute, University Hospital Germans Trias and Pujol de Badalona - Spain In this episode of HFA CardioTalk, Henrike Arfsten interviews Antoni Bayes-Genis on circulating biomarkers in heart failure. They focus in particular on natriuretic peptides and discuss the benefits of biomarkers assessment and their fundamental role in heart failure diagnosis and disease progression. NEW! If you want to know more on this topic, access some recommended readings from the speakers: - Bayes-Genis A, et al.; Eur J Heart Fail. 2023 Sep 15 - Mueller C, et al.; Eur J Heart Fail. 2019 Jun;21(6):715-731. - Bayes-Genis A, et al.; Eur J Heart Fail. 2021:23,1432–1436. - Huelsmann M, et al.; J Am Coll Cardiol. 2013 Oct 8;62(15):1365-72 - Tsutsui H, et al; Eur J Heart Fail. 2023 May;25(5):616-631.

With Chris Kapelios, Onassis Cardiac Surgery Center, Athens - Greece & Gianluigi Savarese, Karolinska University Hospital, Stockholm - Sweden. This HFA CardioTalk podcast episode addresses Clinical inertia and optimization of heart failure therapy. The data we have on use of HF medications come from registries and may not be generalizable to unselected, real-world populations. The proportion of HFrEF patients treated with optimal medical therapy differs considerably among registries (between 70% to >90% for a beta-blocker, 60% to >90% for RASi, 15-45% for ARNI, 30-60% for MRA). It is well documented that optimal HFrEF treatment leads to better quality of life, and reduction in mortality, HF hospitalizations and healthcare costs. Clinical inertia is the lack of treatment intensification in patients not on optimized therapy. Its manifestations may differ from country to country, but it is always present, irrespective of whether the approach to HF medication initiation is sequential or in parallel. Increase of awareness, collaboration of all healthcare professionals, and use of checklists and digital tools are among the measures we can apply to tackle clinical inertia.