

Deep Tech Catalyst
The Scenarionist
Learn every week from global investors and experts how to turn your scientific discoveries into investable Deep Tech startups.
At The Scenarionist, we connect the dots across science, capital, and industrial execution by tracking the patterns, inflection points, and market shifts that matter most, every week.
Subscribe for free to our newsletter and join 2,600+ Deep Tech founders, investors, and operators already in the loop.
Every week, you’ll find curated food for thought. Check it out: https://www.thescenarionist.com/p/what-is-the-scenarionist
At The Scenarionist, we connect the dots across science, capital, and industrial execution by tracking the patterns, inflection points, and market shifts that matter most, every week.
Subscribe for free to our newsletter and join 2,600+ Deep Tech founders, investors, and operators already in the loop.
Every week, you’ll find curated food for thought. Check it out: https://www.thescenarionist.com/p/what-is-the-scenarionist
Episodes
Mentioned books

Nov 24, 2023 • 24min
Are You Ready to Build a Factory? How to Scale Deep Tech Ventures. A chat with DC Palter, Angel investor, Mentor Lead at the CAN, and Executive Committee member at Tech Coast Angels.
In this chat, we dive deep into the complexities and strategic decisions needed to turn a groundbreaking idea into a successful scalable venture with DC Palter, founder with multiple exits, Angel investor, Mentor Lead at the Chemical Angel Network, and Executive Committee member at Tech Coast Angels.
Dive into the intricate world of Deep Tech in this enlightening episode. We'll explore the unique challenges and strategies involved in transitioning from a concept to a marketable product, particularly in hardware versus software development.
This episode is a must-listen for aspiring entrepreneurs and investors in the Deep Tech space, offering valuable insights into licensing dynamics, the valley of death in early-stage startups, and the basics of pricing strategies.
Join us as we unravel the complexities behind the scarcity of unicorns in Deep Tech and decode the secrets of successful scientific pitching.
Host: Nicola Marchese
Guest: DC Palter
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TIMESTAMPS:
(00:00) Intro
(02:00) Are you ready to build a factory?
(06:07) Why can licensing be a good deal for the company but not for Venture Capitalists?
(09:50) What are the main reasons why there are so few unicorns in Deep Tech compared to the software industry?
(14:01) How to face the problem of the valley of death in the early-stage Deep Tech?
(16:43) What should scientific founders prioritize in their pitch deck from day 1?
(20:13) Pricing strategy and Go-to-Market Strategy 101
(21:28) Author Spotlight - DC Palter's 'To Kill A Unicorn'
KEY THEMES COVERED:
1. Are You Ready to Build a Factory? Exploring the contrasts between software and hardware product development, the investor's view on scalability, the critical role of a robust supply chain in hardware production, and the unique challenges faced by entrepreneurs in this realm.
2. Building vs. Licensing in Tech Products: Understanding the critical differences in scalability, investor perspectives, and market challenges between hardware and software development, and the strategic implications of choosing to license vs production.
3. Deep Tech Unicorns: Rarity and Reasons. Analyzing the scarcity of unicorns in Deep Tech compared to the software industry, focusing on the importance of licensing, industry perspectives, and the impact of the climate crisis on investment trends.
4. Navigating the Valley of Death in Early-Stage Deep Tech. Addressing the key factors leading to the early-stage struggles of Deep Tech startups, exploring solutions, and governmental support in the U.S. and Europe.
5. The Art of Scientific Founder Pitching: Delving into what scientific founders must prioritize from day one in their pitch decks, understanding the information asymmetry between scientists and investors, and identifying the key elements that make a pitch deck appealing.
6. Pricing Strategies and Go-To-Market Strategy in Early Stage Deep Tech: Outlining effective pricing strategies and the significance of a robust go-to-market strategy in captivating investor interest and ensuring market traction.
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Nov 17, 2023 • 20min
Scientist to CEO: Mastering VC Engagement & Team Dynamics in Deep Tech. A chat with Colin Webster, Co-Founder at RiSC Capital.
Featuring Colin Webster, Co-Founder at RiSC Capital, we dive deep into the transition from scientist to startup CEO.
Explore the transition from science to startup in this episode, focusing on the right time to seek venture capital, build a balanced team, and avoid common pitfalls in the Deep Tech entrepreneurial journey. Perfect for scientists and investors alike, looking to navigate the complex world of tech innovation.
Host: Nicola Marchese
Guest: Colin Webster
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TIMESTAMPS:
(00:00) Intro
(04:18) When is the right time to approach a VC in Early-Stage Deep Tech?
(09:00) Team Building 101
(11:52) The relationship between the founders is an important part of a startup's evaluation.
(12:51) Pitfalls scientists need to avoid when turning into entrepreneurs.
(14:53) Why is Early-Stage Deep Tech still underinvested today?
(17:51) Why should a scientist become an entrepreneur?
KEY THEMES COVERED:
1. Approaching VCs in Early Stage Deep Tech: Identifying the right time for engagement, understanding the necessity of solid proof of concept, and the nuances of approaching first customers.
2. Essentials of Team Building in Deep Tech Startups: The criticality of team composition, the balance between soft and hard skills, and the advantages of having multiple founders.
3. Founder Relationships and Startup Valuation: Investor perspectives on team dynamics, and the role of founder relationships in due diligence processes.
4. Common Pitfalls for Scientist-Entrepreneurs: Key mistakes to avoid, prioritization challenges, and the strategic importance of early market entry with prototypes.
5. Investment Challenges in Early Stage Deep Tech: Exploring the reasons behind the underinvestment in this sector, and the importance of technical and risk considerations, especially in hardware startups.
6. The Scientist as Entrepreneur: Evaluating the suitability for entrepreneurial ventures in the scientific community, and the key activities and mindset needed for successful entrepreneurship.
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The Scenarionist Website: https://www.thescenarionist.org/
Linkedin The Scenarionist: https://www.linkedin.com/company
Linkedin Nicola Marchese: https://www.linkedin.com/in/nmarchese...

Nov 10, 2023 • 26min
Market Traction & Company Shares 101 for Scientists. A VC's perspective from the Nuclear Tech Sector. A chat with Guerric De Crombrugghe, Founding partner @Nuketech
Featuring Guerric De Crombrugghe, Founding Partner at Nuketech, we dive deep into the intricacies of Market Traction and Company Shares.
Discover how nuclear technology startup founders can navigate today's complex energy landscape. From obtaining crucial market feedback to understanding the value of a letter of intent, this episode covers vital aspects for anyone interested in the future of nuclear energy and Deep Tech.
Host: Nicola Marchese
Guest: Guerric De Crombrugghe
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TIMESTAMPS:
(00:00) Intro
(05:23) How did you come up with the idea of founding a nuclear-focused VC fund?
(06:15) What does a VC look for from founders at TRL4/5? In your opinion, what's the difference between a research project and an investable company in the nuclear sector, and, more broadly, in Deep Tech?
(07:59) How can a STEM founder be sure that what they are developing is relevant to the market?
(10:31) From a venture capitalist's perspective, what significance does a Letter of Intent (LOI) hold for an early-stage Deep Tech startup?
(11:43) Will they steal my idea? Why is it always valuable to get feedback from industry stakeholders?
(12:48) Cap Table and Shares 101: How to be investable from your equity side.
(17:03) What is the usual risk profile of a Nuclear Tech Startup in the context of today’s Nuclear Energy landscape?
(21:52) What are the next emerging trends in nuclear tech?
KEY THEMES COVERED:
1. Nuclear Energy Market: Current opportunities for founders and investors.
2. Venture Capital Insights: Evaluation criteria for projects at TRL4/5, distinguishing between research and investable enterprise in nuclear and Deep Tech.
3. Market Relevance and Traction: The importance of customer feedback, what it means to have market traction, and the effectiveness of a letter of intent.
4. Idea Protection and Communication: Addressing the fear of idea theft and the importance of early communication with clients.
5. Cap Table and Shares: How to make your startup investable and understand the importance of equity in the early stage.
6. Risk Profile of a Nuclear Tech Startup: Risk analysis, supply chain requirements, main bottlenecks, and the need for an infrastructure revolution.
7. Emerging Trends in Nuclear Tech: What are the next trends and innovations in this sector?
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The Scenarionist Website: https://www.thescenarionist.org/
Linkedin The Scenarionist: https://www.linkedin.com/company/thescenarionist
Linkedin Nicola Marchese: https://www.linkedin.com/in/nmarchese-md/

Nov 3, 2023 • 22min
From Science to Success: Crafting The Investable Deep Tech Startup. A chat with Swati Chaturvedi, Co-founder and CEO @Propel(x).
Dive into the essentials of Deep Tech startups with our expert guest, Swati Chaturvedi, Co-founder and CEO of Propel(x) and the pioneer behind the term 'Deep Tech".
This episode is packed with insights on investor engagement, valuations, and exit strategies, tailored for STEM entrepreneurs looking to transform their innovations into successful ventures.
🕒 Episode Timeline:
(00:00) What is Deep Tech?
(05:23) When and how should a STEM entrepreneur approach his first investor?
(10:00) What are the crucial aspects of communicating a science-based entrepreneurial idea to investors?
(12:44) How to start planning the exit strategy for your Deep Tech venture?
(17:05) Assessing market size and comparables: where to begin?
(19:00) How can you understand the valuation of your early-stage Deep Tech company?
🚀 Episode Highlights:
- Exploring the core of Deep Tech and its market impact
- Strategic investor engagement for STEM startups
- Converting complex science into compelling pitches
- 'Time to Money' vs. 'Time to Exit' strategy
- Finding your Deep Tech venture's market fit and valuation
Follow us for the latest in Deep Tech and STEM entrepreneurship.
Website: https://www.thescenarionist.org
#DeepTech #STEMEntrepreneurship #TechInnovation #StartupValuation #InvestorPitch #ExitStrategy #MarketAnalysis #ScienceStartups


