Neurology® Podcast

1. Featured Article: Clinical Reasoning: A young woman with symmetric weakness and behavioral disturbance2. What's Trending: DEFUSE 3 trial results on thrombectomy vs. standard therapy alone for ischemic stroke This Neurology® Podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the April 17, 2018, print issue of Neurology. In the first segment, Dr. Dan Ackerman talks with Dr. Jon Rosenberg about the differential diagnosis of a young patient with symmetric weakness, behavioral changes, and bilateral infarcts. For the "What's Trending" segment, Dr. Nicole Chiota-McCollum speaks with Dr. Gregory Albers about findings from the DEFUSE 3 clinical trial.DISCLOSURES: Dr. Ackerman, Dr. Rosenberg, and Dr. Chiota-McCollum report no disclosures. Dr. Albers has served on a steering committee for Lundbeck and Covidien; serves on the editorial board for Stroke; holds a patent for RAPID software for MRI and CTP analysis of diffusion and perfusion data; has consulted for Astra Zeneca, Biogen, and iSchemaView; holds stock in iSchemaView; and has received research support from NINDS.

1. Featured Article: Rituximab before and during pregnancy: A systematic review, and a case series in MS and NMOSD2. Neurology Today: Top research advances in 2017This Neurology® Podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the April 10, 2018, print issue of Neurology. In the first segment, Dr. Stacey Clardy interviews Dr. Riley Bove about her paper on rituximab treatment before and during pregnancy in patients with multiple sclerosis and NMOSD. For the second segment, Dr. Andy Southerland speaks with Dr. Joseph Safdieh on the Neurology Today editorial selections for the top research advances in 2017.DISCLOSURES: Dr. Clardy has received research support from Western Institute for Biomedical Research (WIBR).Dr. Southerland serves as Podcast Editor for Neurology; receives research support from the American Heart Association-American Stroke Association National Clinical Research Program, American Academy of Neurology, American Board of Psychiatry and Neurology, Health Resources Services Administration and the NIH; has a provisional patent application titled: "Method, system and computer readable medium for improving treatment times for rapid evaluation of acute stroke via mobile telemedicine;" and gave legal expert review. Dr. Safdieh has served on scientific advisory board for Upsher Smith; receives publishing royalties from Rubin MP, Safdieh JE. Netters Concise Neuroanatomy (Elsevier 2007); and serves as Editor-in-Chief of Neurology Today.

1. Featured Article: The Mitochondrial Disease Patients' Diagnostic Odyssey: Results of A Survey2. What's Trending: Teen concussion and early tauopathyThis Neurology® Podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the April 3, 2018, print issue of Neurology. In the first segment, Dr. Jason Crowell talks with Drs. John L.P. Thompson and Michio Hirano about their Neurology: Genetics paper on the long journey to diagnosis for patients with mitochondrial disease. For the "What's Trending" segment, Dr. Jeff Ratliff speaks with Dr. Lee Goldstein about teen concussion and early tauopathy.DISCLOSURES: Dr. Crowell reports no disclosures. Dr. Thompson has recieved research support from Novartis, NIH/NINDS (1U54 NS078059-06), NIEHS (P30 ES009089-15), and the FDA (UFDSP00011270). Dr. Hirano has received honoraria for serving on advisory boards of Stealth Biotherapeutics, Sarepeta, and Biogen; received received travel funds from the American College of Medical Genetics; has served as Nerve and Muscle editor of Current Neurology and Neuroscience Reports (2002-present); holds Rare Pediatric Disease (RPD) and Orphan Drug Designations (ODD) for deoxynucleoside therapy for mitochondrial DNA depletion syndrome including TK2 deficiency; received honoraria as a member of the Speakers' Bureau of Athena Diagnostics; and received research support from Santhera Pharmaceutical, Edison Pharmaceutical, National Institutes of Health (U54NS078059, R01HD056103 RC1NS070232 P01HD032062), Muscular Dystrophy Association (MDA) USA and Marriott Mitochondrial Disorder Clinical Research Fund (MMDCRF). Dr. Goldstein is a consultant for Rebiscan, Inc. Dr. Ratliff has received a speaker honorarium from Haverford College.

This special Delayed Recall episode is the third installment of our new Practice Current segment. In this episode, Dr. Luca Bartolini speaks with epilepsy experts Dr. Cynthia Harden and Dr. Torbjörn Tomson. They discuss the results of a recent Practice Current (a section of Neurology® Clinical Practice) survey regarding epilepsy treatment and management during pregnancy, and share their thoughts regarding best practices. This is the first appearance of this interview in the podcast.

1. Featured Article: IgLON5 antibody: Neurological Accompaniments & Outcomes in 20 patients2. What's Trending: Health policy update - Coding, Reimbursement & Quality Payment ProgramThis Neurology® Podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the March 27, 2018, print issue of Neurology. In the first segment, Dr. Stacey Clardy talks with Dr. Andrew McKeon about his Neurology: Neuroimmunology & Neuroinflammation paper describing IgLON5 autoimmunity. For the "What's Trending" segment, Dr. Jason Crowell speaks with Luana Ciccarelli and Amanda Napoles on regulatory updates in coding and reimbursement, MACRA, and tips for private practitioners on participating in the Quality Payment Program.DISCLOSURES: Dr. Clardy has received research support from Western Institute for Biomedical Research (WIBR).Dr. McKeon has patent applications pending for GFAP and MAP1B as markers of neurological autoimmunity and paraneoplastic disorders; has consulted for Grifols, Medimmune, Inc., and Euroimmun (but did not receive personal compensation for these activities); and has received research support from Medimmune, Inc. and Euroimmun. Dr. Crowell reports no disclosures. Luana Ciccarelli and Amanda Napoles are employed by the American Academy of Neurology.

1. Featured Article: Molecular Genetic Testing for Hereditary Ataxia – What Every Neurologist Should Know2. What's Trending: Recent changes to Maintenance of Certification Requirements This Neurology® Podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the March 20, 2018, print issue of Neurology. In the first segment, Dr. Jeff Ratliff talks with Dr. Thomas Bird about his Neurology: Clinical Practice paper on the benefits and limitations of exome sequencing to identify hereditary ataxias. For the "What's Trending" segment, Dr. Stacey Clardy with Dr. Laurie Gutmann about recent updates to the Maintenance of Certification requirements and tips to ease the process for neurologists.DISCLOSURES: Dr. Bird serves on the editorial board for GeneReviews.org; holds patents for genetic testing technology for CMT1C and SCA14; and has received research support from the Department of Veterans' Affairs (Merit Research Grant, PI, 2009-2017). Dr. Gutmann serves on the editorial board for Up-to-Date Online (Hypokalemic and Hyperkalemic Periodic Paralysis); and has recieved research support from Alexion Pharmaceuticals, Inc. and the NIH (U01 NS069498-01 A1, 3P50NS044283-07S1, U01 NS026835-01A1, U01 NS058728-01, and U01 NS077179-01). Dr. Ratliff has received a speaker honorarium from Haverford College. Dr. Clardy has received research support from Western Institute for Biomedical Research (WIBR).

1. Featured Article: Atrial fibrillation detected after stroke is related to a low risk of ischemic stroke recurrence2. What's Trending: Evaluation of idiopathic transverse myelitis revealing specific myelopathy diagnosesThis Neurology® Podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the first segment, Dr. Mark McAllister talks with Dr. Luciano Sposato about their paper on the relationship between atrial fibrillation detection and ischemic stroke recurrence. For the "What's Trending" segment, Dr. Ted Burns speaks with Dr. Mark Keegan and Dr. Nick Zalewski about their paper on idiopathic transverse myelitis and myelopathy diagnoses.DISCLOSURES: Dr. Sposato has received travel or speaker honoraria from Boehringer Ingelheim and Pfizer; serves on the Editorial Board for Neurology; and has received research support from Kathleen & Dr Henry Barnett Research Chair in Stroke Research, Boehringer Ingelheim (salary support for a fellow), Edward and Alma Saraydar Neurosciences Fund, Opportunities Fund of the Academic Health Sciences Centre Alternative Funding Plan of the Academic Medical Organization of Southwestern Ontario, and Boehringer Ingelheim. Dr. Keegan serves on the editorial board for Multiple Sclerosis and Related Disorders; receives publishing royalties for Common Pitfalls in Multiple Sclerosis and CNS Demyelinating Diseases: Case-Based Learning (Cambridge University Press, 2016); has consulted for Novartis, Bristol Meyers Squibb, and Bionest; and has received research support from Biogen (ARISE study). Dr. Burns is the deputy section editor of the Neurology® podcast; has served on scientific advisory boards for Argenx, UCB, and CSL Behring; has received travel funding/speaker honoraria from Argenx and Alexion; and has received support for consulting activities from UCB Pharma and CSL Behring. Dr. McAllister and Dr. Zalewski report no disclosures.

This month's Delayed Recall episode includes three recent interviews on the topic of cognitive impairment. In the first interview, from the January 16, 2018 episode, Dr. Jeff Burns speaks with Dr. Ronald Petersen about the recent AAN practice guideline paper on mild cognitive impairment. Next, in and interview from the January 2, 2018 podcast, Dr. Ted Burns and Dr. Damian Garde discuss recent Alzheimer disease trials; and in the third and final interview, Dr. Matthew Elliot talks with Dr. Hugh Markus about his paper "Multimodal MRI markers and dementia risk in cerebral small vessel disease." This interview first aired in the October 31, 2017 episode of the podcast.

1. Featured Article: Relapse occurrence in women with multiple sclerosis during pregnancy in the new treatment era2. What's Trending: Sleep architecture and risk of dementiaThis podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the March 6, 2018, issue of Neurology. In the first segment, Dr. Stacey Clardy talks with Dr. Raed Alroughani about his article on relapse recurrence during pregnancy in women with multiple sclerosis. In the second part of the podcast, you'll hear Dr. Jeff Burns interviews Dr. Sudha Seshadri about sleep and dementia risk.DISCLOSURES: Dr. Clardy has received research support from Western Institute for Biomedical Research (WIBR). Dr. Alroughani served in scientific advisory boards of Novartis, Bayer, Merck-Sorono, Roche, Biogen, Sanofi-Geznyme; has received speaker and travel honoraria from Novartis, Bayer, Merck-Sorono, Biogen, Roche, Sanofi-Genzyme and GSK; and has received research grants from Biogen, Novartis and Sanofi-Genzyme.Dr. Burns has served on the DSMB for NIH-funded trials (non-profit entities); serves on the editorial board for Journal of Alzheimer's Disease; has consulted for Grifols, USA; has served on Eli Lilly Amyvid Speaker's Bureau; and has received research support from Eli Lilly, Avid Radiopharmaceuticals, Toyama Chemical Company, Merck, Biogen, AbbVie, Novartis, vTv Therapeutics, Janssen, and NIH (R01AG058557, R01AG053312, R01AG034614, R01AG03367, R01AG043962, P30AG035982, U10NS077356, UL1TR000001).Dr. Seshadri serves on editorial boards for Journal of Alzheimer's Disease, Stroke, and Neurology; and has received research support from NIA (AG008122, AG033040, AG049505, AG033193, AG049607, AG054076).

1. Featured Article: Interdisciplinary Response to Contemporary Concerns about Brain Death Determination2. What's Trending: Gene Drive, part 2This podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the February 27, 2018 issue of Neurology. In the first segment, Dr. Andy Schomer talks with Dr. Ariane Lewis about her paper on the determination of brain death. In the second part of the podcast, Dr. Ted Burns speaks with Dr. Kevin Esvelt for part two of the discussion on gene drives (the first of these segments aired in the Feb. 20 episode).