Neurology® Podcast

The February 2026 recall features four previously posted episodes on multiple sclerosis. The episode begins with a conversation with Dr. Wallace J. Brownle discussing whether dissemination in time is essential to diagnois relapsing MS. The discussion continues with Dr. Daniel Ontaneda regarding the 2024 revisions of the McDonald criteria for diagnosing multiple sclerosis. The episode then transitions into a conversation with Dr. Jiwon Oh about BTK inhibitors and recent data on tolebrutinib in multiple sclerosis. The episode concludes with Dr. Sandra Vukusic addressing the differences in disease-modifying therapies for female versus male patients with multiple sclerosis. Podcast link: Investigating Whether Dissemination in Time Is Essential to Diagnose Relapsing MS 2024 McDonald Criteria BTK Inhibitors in Multiple Sclerosis Treatment Sex-Related Gap in the Use of Disease-Modifying Therapies in Multiple Sclerosis Podcast article: Investigating Whether Dissemination in Time Is Essential to Diagnose Relapsing Multiple Sclerosis Diagnosis of Multiple Sclerosis: 2024 Revisions of the McDonald Criteria Tolebrutinib versus Teriflunomide in Relapsing Multiple Sclerosis Tolebrutinib in Nonrelapsing Secondary Progressive Multiple Sclerosis Sex-Related Gap in the Use of Disease-Modifying Therapies in Multiple Sclerosis Disclosures can be found at Neurology.org.

Dr. Tesha Monteith talks with Dr. Michael Eller about the implications of CGRP therapies in migraine treatment, particularly for patients with vascular risk factors or a history of stroke. Read the related article in Neurology®. Disclosures can be found at Neurology.org.

Dr. Stacey Clardy talks with Dr. John Ney about the prevalence, disability burden, and societal impact of neurologic disorders in the U.S. Read the related article in JAMA. Disclosures can be found at Neurology.org.

In the second episode of this two-part series, Dr. Justin Abbatemarco talks with Drs. Valérie Biousse and Nancy J. Newman about the management of non-arteritic ischemic optic neuropathy and its emerging relationship with GLP‑1 medications. Disclosures can be found at Neurology.org.

In part one of this two-part series, Dr. Justin Abbatemarco talks with Drs. Valérie Biousse and Nancy J. Newman about the clinical features and diagnostic tools utilized for non-arteritic ischemic optic neuropathy (NAION). Disclosures can be found at Neurology.org.

Dr. Justin Abbatemarco talks with Dr. Divyanshu Dubey about how antibodies to synaptophysin and GAP43 help explain an autoimmune neuropathy seen in swine abattoir workers and offer new clues for diagnosing and treating related inflammatory neuropathies. Read the related article in ScienceDirect. Disclosures can be found at Neurology.org.

Dr. Ayush Gupta, a neurologist and researcher in neurological sciences, dives into the intriguing world of monogenic disorders mimicking neuroinflammatory conditions. He highlights essential clinical clues for diagnosing LBSL and late-onset Alexander disease. The discussion also covers the importance of genetic testing, addressing the challenges of interpreting variants of uncertain significance, and the necessity of collaboration with genetic counselors. Gupta emphasizes recognizing key red flags in nonresponsive cases, urging clinicians to refine their diagnostic approaches.

Dr. Ayush Gupta, a neurologist and neurogenetics clinician-scientist, dives into the fascinating world of monogenic disorders that imitate neuroinflammatory diseases. He highlights the diagnostic challenges and the importance of recognizing red flags in children versus adults. Topics include practical clues for identifying genetic causes in MS-like cases and the implications of misdiagnosing genetic conditions as autoimmune disorders. Ayush also discusses innovative treatments for conditions like Aicardi-Goutières and the significance of newborn screening for adrenoleukodystrophy.

Dr. Elizabeth Coon talks with Prof. Franziska Hopfner about the frequency and disease trajectory of MSA patients who do not experience dysautonomia, in comparison to those with autonomic involvement. Read the related article in Neurology®. Disclosures can be found at Neurology.org.

Stephen Marche, a novelist and columnist, shares insights on the implications of AI in writing and neurology. Sándor Beniczky discusses SCORE-AI's role in automating EEG interpretations, enhancing diagnostic workflow. David T. Jones presents StateViewer, a machine-learning tool that boosts diagnostic accuracy in neurodegenerative disorders. Adam Rodman highlights the potential of large language models in clinical reasoning while stressing the importance of clinician involvement. The conversation weaves through the transformative impact of AI on medicine and the necessity for human connection.