Live Well Be Well with Sarah Ann Macklin | Health, Lifestyle, Nutrition

Your neurons can become younger.Your gut can reshape itself in five days.Your immune system can learn to fight cancer.This isn't theory. It's mycology.And it's about to change how you think about what your body can do.This week on Live Well Be Well, I sit down with Dr. Catalina Fernández de Ana Portela, a pioneering mycologist and oncologist who’s spent 26 years unlocking the therapeutic power of mushrooms. From Lion’s Mane and Reishi to Cordyceps, she’s led clinical trials across cancer, autism, neurodegenerative disease, and fertility, quietly reshaping how we think about prevention, healing, and the intelligence of nature.In this episode, we explore:The real science behind Lion's Mane: neuroplasticity, contains GABA, and why your neurons can actually become youngerWhy Lion's Mane may support brain health, gut health, autism, Alzheimer's, multiple sclerosis, and Parkinson's treatmentHow Reishi could help reduce stress and anxiety, and modulate neurotransmitters like GABAThe real science behind putting mushrooms in your coffee (yes, it's more than a trend!)What Cordyceps does for energy, fertility, and performance, and how mushrooms support both male and female reproductive healthBreakthrough research on mushrooms in integrative oncology, including their effects on the gut microbiome and immune systemThe gut-brain axis: how mushrooms can reshape your microbiome in 5 days and support conditions from autism to cancerThe supplement quality crisis: why only 25% of products contain what they claim and how to find trustworthy brandsWhether you're curious about adding Lion's Mane to your morning coffee, wondering if Reishi could actually help your anxiety, or want to understand how mushrooms are being used alongside chemotherapy in clinical trials, this conversation will change how you think about what's possible. The question isn't whether mushrooms work. The science is undeniable. Now it's about finding the right approach for you.Love,Sarah Ann 💛***This episode is sponsored by Spatone – the No.1 iron-rich water supplement.This is a product I genuinely believe in — one I’ve used personally and recommended in the clinic for years. Spatone is a natural iron-rich water that’s incredibly gentle on the stomach. No harsh tablets, no digestive upset — just one naturally sourced ingredient that works.If you’re looking for iron support that actually feels good to take, this is the one I trust. You can pick up Spatone at Boots: Spatone Apple Daily Iron Shots + Vitamin C 28 Sachets - Boots**This episode is also sponsored by London Nootropics, the best-in-class adaptogenic coffee I trust. Made with Hifas da Terra mushroom extracts, it supports focus, calm, and energy, and helps you stay sharp throughout the day. Enjoy 20% off with code LIVEWELLBEWELL at londonnootropics.com***If you enjoyed this episode, you might also like:Dr. William Li: 5 Must-Eat Foods to Fight Cancer⁠https://www.youtube.com/watch?v=WHWHT2cJNkE***Sign up to Sarah’s Compassionate Cure newsletter: Science Simplified, Health Humanised. Join thousands in exploring actionable insights that prioritise compassion, clarity, and real-life impact. https://sarahmacklin.substack.com/***Highlights:Intro (00:00)Lion’s Mane: Neuroplasticity and Brain Health Benefits (02:35)Lion’s Mane: Neuroprotection for Alzheimer’s and Parkinson’s (09:56)The Importance of Consistency for Long-Term Benefits (14:51)How Lion's Mane and Reishi in Coffee Boost Focus and Calm (17:06)Cordyceps: The Performance-Boosting Mushroom for Energy (22:05)Can Cordyceps Improve Fertility and Sperm Quality? (26:00)Mushrooms in Cancer Treatment: Immune & Gut Health Support (32:37)How to Navigate Mushroom Quality (42:07)Final Takeaways: The Power of Medicinal Mushrooms (47:27)***Let’s be friends!📷 Instagram:  / sarahannmacklin📹 Subscribe:   / @livewellbewellsarah  🐦 Twitter:  / sarahannmacklin  📱 TikTok:  / sarahannnutrition 

How does emotional health influence your physical well-being? In this video, Kate Tolo shares her personal journey of how addressing emotional barriers helped transform her diet and overall health. Can emotional healing unlock lasting physical health? Watch to discover how emotional health is the key to unlocking a better, healthier you.Kate ToloListen to the full episode⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.Watch the full episode on YouTube ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.⁠***This episode is sponsored by Spatone – the No.1 iron-rich water supplement.This is a product I genuinely believe in — one I’ve used personally and recommended in the clinic for years. Spatone is a natural iron-rich water that’s incredibly gentle on the stomach. No harsh tablets, no digestive upset — just one naturally sourced ingredient that works.If you’re looking for iron support that actually feels good to take, this is the one I trust. You can pick up Spatone at Boots: ⁠⁠Spatone Apple Daily Iron Shots + Vitamin C 28 Sachets - Boots⁠⁠**This episode is also sponsored by London Nootropics, the best-in-class adaptogenic coffee I trust. Made with Hifas da Terra mushroom extracts, it supports focus, calm, and energy, and helps you stay sharp throughout the day. Enjoy 20% off with code LIVEWELLBEWELL at ⁠⁠londonnootropics.com⁠⁠***If you enjoyed this episode you might also like:The FIRST Woman To Follow Bryan Johnson’s $2M Anti-Aging Blueprint | Why Kate Tolo Is Differenthttps://youtu.be/BJC_E_gXYMg***Sign up to Sarah’s Compassionate Cure newsletter: Science Simplified, Health Humanised. Join thousands in exploring actionable insights that prioritise compassion, clarity, and real-life impact. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://sarahmacklin.substack.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠***Let’s be friends!📷 Instagram:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠  / sarahannmacklin⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠📹 Subscribe:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠   / @livewellbewellsarah  ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠🐦 Twitter:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠  / sarahannmacklin  ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠📱 TikTok:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠  / sarahannnutrition  ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠💌 Newsletter: https://bit.ly/3rUbHyS#EmotionalHealth, #PhysicalWellBeing, #HealthTransformation

What does it cost to follow your own map?Dr. Emeran Mayer, pioneer of the mind-gut connection, shares the unexpected choices that defined his life from resisting conformity to overcoming early fears. In this short, reflective episode, he explains why one small change rewired his path and what he still struggles to make peace with.Dr. Emeran MayerListen to the full episode⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.Watch the full episode on YouTube ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.***This episode is sponsored by Spatone – the No.1 iron-rich water supplement.This is a product I genuinely believe in — one I’ve used personally and recommended in the clinic for years. Spatone is a natural iron-rich water that’s incredibly gentle on the stomach. No harsh tablets, no digestive upset — just one naturally sourced ingredient that works.If you’re looking for iron support that actually feels good to take, this is the one I trust. You can pick up Spatone at Boots: ⁠Spatone Apple Daily Iron Shots + Vitamin C 28 Sachets - Boots⁠**This episode is also sponsored by London Nootropics, the best-in-class adaptogenic coffee I trust. Made with Hifas da Terra mushroom extracts, it supports focus, calm, and energy, and helps you stay sharp throughout the day. Enjoy 20% off with code LIVEWELLBEWELL at ⁠londonnootropics.com⁠***If you enjoyed this episode you might also like:The Gut-Mind Doctor: The Mind & Food Strategies That Can Heal Your Gut Microbiome | Dr. Emeran Mayerhttps://youtu.be/yL5ZtoJAUBs***Sign up to Sarah’s Compassionate Cure newsletter: Science Simplified, Health Humanised. Join thousands in exploring actionable insights that prioritise compassion, clarity, and real-life impact. ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://sarahmacklin.substack.com/⁠⁠⁠⁠⁠⁠⁠⁠***Let’s be friends!📷 Instagram:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠  / sarahannmacklin⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠📹 Subscribe:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠   / @livewellbewellsarah  ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠🐦 Twitter:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠  / sarahannmacklin  ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠📱 TikTok:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠  / sarahannnutrition  ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠💌 Newsletter: https://bit.ly/3rUbHyS#MindGutConnection, #PurposeDrivenLife, #HighAchieverTruths

Dr. Rick Doblin, founder of MAPS and an advocate for psychedelic therapy, shares his revolutionary insights on how MDMA can treat PTSD. He recounts his early experiences with psychedelics, revealing their potential for healing trauma through interconnectedness. Rick explains the neurobiology of PTSD, detailing how MDMA aids in reducing fear and enhancing empathy. He discusses the importance of integration and the therapeutic protocol designed for safety. With optimism for FDA approval, he highlights the growing support for psychedelic therapy in mental health.

Join Doug Evans, author of The Sprout Book and a dedicated sprouting advocate, as he dives into the incredible benefits of sprouts. He reveals how these tiny superfoods can boost protein levels and combat iron deficiency, particularly for women. Doug shares his personal journey into sprouting, highlighting its role in enhancing food equality. Plus, learn how to sprout at home easily and why this trend is gaining momentum as a powerful nutritional upgrade for any diet.

What happens when you achieve everything you set out to, and still feel empty? In this conversation with Simon Sinek, he shares the painful turning point that led to Start With Why, how ADHD became his greatest asset, and why so many exceptional leaders carry hidden struggles. The answers aren't in performance, they’re in self-awareness, vulnerability, and knowing how to ask the right questions.Listen to the full episode ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.Watch the full episode on YouTube ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.***This episode is sponsored by Spatone – the No.1 iron-rich water supplement.This is a product I genuinely believe in — one I’ve used personally and recommended in the clinic for years. Spatone is a natural iron-rich water that’s incredibly gentle on the stomach. No harsh tablets, no digestive upset — just one naturally sourced ingredient that works.If you’re looking for iron support that actually feels good to take, this is the one I trust. You can pick up Spatone at Boots: ⁠Spatone Apple Daily Iron Shots + Vitamin C 28 Sachets - Boots***If you enjoyed this episode you might also like:Simon Sinek: The ADHD Superpower - Why It’s My Greatest Advantagehttps://youtu.be/_wopj2Qk-4c***Sign up to Sarah’s Compassionate Cure newsletter: Science Simplified, Health Humanised. Join thousands in exploring actionable insights that prioritise compassion, clarity, and real-life impact. ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://sarahmacklin.substack.com/⁠⁠⁠⁠⁠⁠⁠⁠***Let’s be friends!📷 Instagram:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠  / sarahannmacklin⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠📹 Subscribe:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠   / @livewellbewellsarah  ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠🐦 Twitter:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠  / sarahannmacklin  ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠📱 TikTok:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠  / sarahannnutrition  ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠💌 Newsletter: https://bit.ly/3rUbHyS#SimonSinek #Neurodivergence #StartWithWhy

You've been told your hormones make you irrational.That menopause means cognitive decline, your emotions are just chemistry gone wrong, and your brain is simply too complicated to understand.Science says otherwise.This week's guest, Dr. Sarah McKay, is a neuroscientist, author, and brain health expert who's spent her career dismantling the myths we've been told about women's brains. From the idea that we're slaves to our hormones to the fear that menopause means inevitable decline, Sarah brings data, nuance, and hope to conversations that have been shaped by outdated stereotypes for far too long.We explore:Why male and female brains are more similar than different, and how cultural context shapes the differences we do seeThe surprising truth about PMS: how rates vary from 12% in France to 90% in IranWhy the stereotype that women are "more emotional" isn't backed by scienceHow your brain actually changes during menopauseThe real relationship between hormones, sleep, and brain fogWhy early puberty affects girls and boys so differentlyWhat brain networks do when estrogen declinesThe truth about HRT and brain health: what the data actually showsHow expectations and cultural narratives create the experiences we haveSarah doesn't dismiss women's struggles or minimize real symptoms. Instead, she offers something more powerful: the understanding that our brains are not broken, fragile, or at the mercy of our biology. They're sophisticated, adaptive, and capable of remarkable reorganization throughout our lives.This isn't about toxic positivity or dismissing genuine challenges. It's about recognizing that the stories we've been told about women's brains, that we're irrational, unstable, or declining, aren't just wrong. They're actively shaping our reality.Love,Sarah Ann 💛***This episode is sponsored by Spatone – the No.1 iron-rich water supplement.This is a product I genuinely believe in — one I’ve used personally and recommended in the clinic for years. Spatone is a natural iron-rich water that’s incredibly gentle on the stomach. No harsh tablets, no digestive upset — just one naturally sourced ingredient that works.If you’re looking for iron support that actually feels good to take, this is the one I trust. You can pick up Spatone at Boots: Spatone Apple Daily Iron Shots + Vitamin C 28 Sachets - Boots***If you enjoyed this episode, you might also like:⁠Dr. Stacy Sims EXPOSES the Myths Hurting Women's Health | Fasting, Protein & Exercisehttps://www.youtube.com/watch?v=E1uksGzoick&tEllen Langer: The Mind Can Slow Down an Aging Bodyhttps://www.youtube.com/watch?v=VGpNMy1VxsY&t***Sign up to Sarah’s Compassionate Cure newsletter: Science Simplified, Health Humanised. Join thousands in exploring actionable insights that prioritise compassion, clarity, and real-life impact. https://sarahmacklin.substack.com/***Highlights:Introduction (0:00:00)Sex Differences in Brain Anatomy (0:01:05)How Culture Shapes Gender Influences (0:04:38)PMS & Emotions: Are Women Really More Sensitive?(0:09:42)Global Stats: How Common is PMS Around the World? (0:14:54)Anxiety & Depression Statistics (0:22:35) Gender Roles, Social Conditioning & Brain Behavior (0:29:38) Women's Neuroscience: Progress, Challenges, and Representation (0:37:58)Menopause Brain Fog: What Science Really Says (0:40:39) Menopause and Cognitive Gains: Surprising Brain Benefits (0:44:58) How HRT Impacts Brain Health (0:51:17) How Women Can Improve Brain Health & Longevity (1:06:16) What Living Well Means to Dr. Sarah McKay (1:08:48) ***Let’s be friends!📷 Instagram:  / sarahannmacklin📹 Subscribe:   / @livewellbewellsarah  🐦 Twitter:  / sarahannmacklin  📱 TikTok:  / sarahannnutrition  💌 Newsletter: https://sarahmacklin.substack.com/

Does understanding your menstrual cycle unlock better health, fertility, and performance? In this conversation with Dr. Stacy Sims, she breaks down the four phases of your cycle, reveals why anovulatory cycles are becoming more common, and explains how stress, diet, and lifestyle directly impact your hormones. From tracking your bleed patterns to understanding why women need different nutrition than men, this isn't just about periods. It's about optimizing your entire well-being.Dr. Stacy SimsListen to the full episode⁠ ⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠.Watch the full episode on YouTube ⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠.***If you enjoyed this episode you might also like:Dr. Stacy Sims on Perimenopause & How to Manage Symptoms | Fitness and Nutrition for WOMENhttps://www.youtube.com/watch?v=hsaGZXiEbNs&list=PLfXKbjBGaUhb8BME00cxF6YPp1J5EcO7j&index=18***Sign up to Sarah’s Compassionate Cure newsletter: Science Simplified, Health Humanised. Join thousands in exploring actionable insights that prioritise compassion, clarity, and real-life impact. ⁠⁠⁠⁠⁠⁠⁠⁠https://sarahmacklin.substack.com/⁠⁠⁠⁠⁠⁠⁠***Let’s be friends!📷 Instagram:⁠⁠⁠⁠⁠⁠⁠⁠⁠  / sarahannmacklin⁠⁠⁠⁠⁠⁠⁠⁠⁠📹 Subscribe:⁠⁠⁠⁠⁠⁠⁠⁠⁠   / @livewellbewellsarah  ⁠⁠⁠⁠⁠⁠⁠⁠⁠🐦 Twitter:⁠⁠⁠⁠⁠⁠⁠⁠⁠  / sarahannmacklin  ⁠⁠⁠⁠⁠⁠⁠⁠⁠📱 TikTok:⁠⁠⁠⁠⁠⁠⁠⁠⁠  / sarahannnutrition  ⁠⁠⁠⁠⁠⁠⁠⁠⁠💌 Newsletter: https://bit.ly/3rUbHyS#MenstrualCycle #HormoneHealth #5Questions

What if the drug that could save your life… already exists? In this powerful story from David Fajgenbaum, you'll hear how a man on the brink of death discovered an existing drug, never approved for his illness, that brought him back. But the real shock? No one profits from it, so no one’s looking. Learn the hidden world of drug repurposing, AI-driven discovery, and the mission to match life-saving treatments to the people who need them most.Listen to the full episode ⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠.Watch the full episode on YouTube ⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠.***If you enjoyed this episode you might also like:How AI is Revolutionizing Medicine | The Doctor Who Saved Himself With AI | Dr. David Fajgenbaumhttps://youtu.be/cE4ytfAw614***Sign up to Sarah’s Compassionate Cure newsletter: Science Simplified, Health Humanised. Join thousands in exploring actionable insights that prioritise compassion, clarity, and real-life impact. ⁠⁠⁠⁠⁠⁠⁠⁠https://sarahmacklin.substack.com/⁠⁠⁠⁠⁠⁠⁠***Let’s be friends!📷 Instagram:⁠⁠⁠⁠⁠⁠⁠⁠⁠  / sarahannmacklin⁠⁠⁠⁠⁠⁠⁠⁠⁠📹 Subscribe:⁠⁠⁠⁠⁠⁠⁠⁠⁠   / @livewellbewellsarah  ⁠⁠⁠⁠⁠⁠⁠⁠⁠🐦 Twitter:⁠⁠⁠⁠⁠⁠⁠⁠⁠  / sarahannmacklin  ⁠⁠⁠⁠⁠⁠⁠⁠⁠📱 TikTok:⁠⁠⁠⁠⁠⁠⁠⁠⁠  / sarahannnutrition  ⁠⁠⁠⁠⁠⁠⁠⁠⁠💌 Newsletter: https://bit.ly/3rUbHyS#DrugRepurposing #AIinHealthcare #MedicalBreakthrough

In this conversation, gut-brain researcher Emily Leeming shares her insights on the intricate relationship between our microbiomes and lifestyle. She explains how stress, trauma, and even intimate connections, like kissing, can dramatically influence gut health. Emily reveals fundamental differences in the microbiomes of men and women, linking hormonal changes to these variations. Learn why loneliness can be as detrimental as poor diet and uncover the surprising role of breathwork in enhancing gut wellness.