JAMA Clinical Reviews

JAMA Senior Editor Kristin Walter, MD, MS, speaks with Fernando Zampieri, MD, PhD, assistant professor in the Department of Critical Care Medicine at the University of Alberta in Alberta, Canada, about fluid therapy in critically ill adults with sepsis. Related Content: Fluid Therapy for Critically Ill Adults With Sepsis

Transgender and gender diverse persons may desire gender-affirming medical and surgical treatment that can mitigate psychologic distress and reduce suicide risk. JAMA Associate Editor David L. Simel, MD, MHS, speaks with Andrew M. Davis, MD, MPH, University of Chicago, and Tonia Poteat, PhD, PA-C, MPH, University of North Carolina, Chapel Hill, about the Standards of Care for the Health of Transgender and Gender Diverse People, Version 8 guidelines. Related Content: Standards of Care for Transgender and Gender Diverse People

Prevalence and causes of cirrhosis in the US, declining prevalence of hepatitis C. Usefulness of history and additional tests in diagnosing cirrhosis. Strategies to improve survival and quality of life for patients with compensated cirrhosis. Management of common symptoms and complications in cirrhosis.

Interview with Gbenga Ogedegbe, MD, MPH, USPSTF member and coauthor of Screening for Latent Tuberculosis Infection in Adults: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Screening for Latent Tuberculosis Infection in Adults Screening for Latent Tuberculosis Infection Among Non–US-Born Adults in the US Screening for Latent Tuberculosis Infection in Adults Screening for Latent Tuberculosis

Interview with Katrina E. Donahue, MD, MPH, USPSTF member and coauthor of Screening for Skin Cancer: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Skin Cancer Screening Screening and Prevention of Skin Cancer Screening for Skin Cancer What Is Mohs Surgery? Skin Cancer Screening

One in 3 adults in the US has prediabetes. JAMA Associate Editor David L. Simel, MD, interviews Samuel Dagogo-Jack, MD, who is the chief of the Division of Endocrinology, Diabetes, and Metabolism at the University of Tennessee, about the diagnosis, screening, complications, lifestyle interventions, and medications for prediabetes. Related Content: Diagnosis and Management of Prediabetes

Chronic lymphocytic leukemia (CLL) affects more than 200 000 people and is associated with >4000 deaths in the US annually. Many people have asymptomatic disease and can be monitored without treatment for long periods. In this podcast, author Mazyar Shadman, MD, MPH, from the University of Washington, Seattle, joins JAMA Deputy Editor Mary M. McDermott, MD, in a discussion about diagnosis and management of CLL. Related Content: Diagnosis and Treatment of Chronic Lymphocytic Leukemia

Approximately 3 million people in the US have heart failure with preserved ejection fraction (HFpEF). JAMA Executive Editor Gregory Curfman, MD, discusses diagnosis and treatment of HFpEF with authors Margaret Redfield, MD, and Barry Borlaug, MD, both from Mayo Foundation for Medical Education and Research Division of Cardiovascular Diseases. Related Content: Heart Failure With Preserved Ejection Fraction

More than 2 million individuals in the US are chronically infected with hepatitis C, and nearly 15 000 die every year. Antivirals are available but are not reaching the majority of infected individuals. In this Q&A, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, and Francis S. Collins, MD, PhD, discuss a plan to eliminate hepatitis C included in the Biden-Harris 2024 budget proposal. Related Content: A National Hepatitis C Elimination Program in the United States Eliminating Hepatitis C in the United States Former NIH Director Francis S. Collins on the New White House Plan to Eliminate Hepatitis C Association of Direct-Acting Antiviral Therapy With Liver and Nonliver Complications and Long-term Mortality in Patients With Chronic Hepatitis C After 12 Years, NIH Director Francis S. Collins, MD, PhD, Seeks His Next Chapter After 12 Years, NIH Director Francis S. Collins Seeks His Next Chapter

In January 2023, the US Organ Procurement & Transplantation Network (OPTN) required transplant centers to modify transplant list wait times for Black patients. JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, and L. Ebony Boulware, MD, MPH, Dinushika Mohottige, MD, MPH, and Tanjala S. Purnell, PhD, MPH, discuss why the OPTN mandate is a valuable model for reforming race-based practices. Related Content: Race-Neutral Estimates of Kidney Function: Enhancing Equity Race-Based Equations Delayed Black Patients From Getting Onto Kidney Transplant Lists—An Unprecedented New Policy Seeks to Undo the Damage Redressing the Harms of Race-Based Kidney Function Estimation