Live Long and Master Aging

Deborah Maragopoulos, a nurse practitioner and self-described intuitive healer, believes health and longevity starts with the hypothalamus region of the brain. In her book, the Hypothalamus Handbook, she bridges the gap between traditional medicine and complementary therapies, revealing how a blend of botanicals, nutraceuticals, and intuition not only works alongside evidence-based medicine but can profoundly impact our health. Deborah, a past president of the California Association of Nurse Practitioners, is the founder of Genesis Health Products, Inc. and creator of the nutraceutical supplement, Genesis Gold®. In this interview, we travel through the body's complex systems, controlled by the hypothalamus, and explore the role this part of the brain plays in every day health and wellbeing.Deborah discusses the power of targeted nutrients and her own botanical formulations, for rebalancing our body's systems. She recounts patient stories, emphasizing the importance of early detection of hypothalamic imbalances that could be the key to longevity and a 'harmonious life.' Check out Genesis Health products, hereWatch the interview at YouTubeFit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

It is that time of the year when we are all acutely aware of the importance of our immune system. But it's about more than catching a winter cold. The health of our natural defense system is crucial to long-term health. Dr. Nicola Vannini is a researcher in the Department of Oncology at the University of Lausanne, in Switzerland.  In this conversation we discuss new research that suggests dietary supplementation with Urolithin A could help boost the immune system. The study (in mice) suggests the compound, which targets mitochondria, is able to reverse the decline in hematopoietic stem cells, which play an essential role in blood health. Could these findings offer hope to older adults as they experience a decline in the efficiency of their immune system?READ THE PAPERInduction of mitochondrial recycling reverts age-associated decline of the hematopoietic and immune systems (Nature Aging)Watch the interview at YouTubeThis interview includes: Recap of urolithin A and its role in promoting metabolic fitness and reducing the accumulation of waste in the cells. Discussion of hematopoietic stem cells and their decline in function with age. Description of Vannini's research on urolithin A and its effects on hematopoietic stem cells in two sets of experiments: ex-vivo and in mice. "Astonishing" results of the experiments, showing that urolithin A treatment improved the function of old hematopoietic stem cells to match that of young stem cells, and enhanced immune response in mice. Potential applications of urolithin A in reversing immunosenescence and improving immune function in elderly individuals and cancer patients who have undergone chemotherapy. Broad impact of urolithin A on various organs and diseases due to its effects on the immune system. Discussion on the role of exercise and nutrition in conjunction with urolithin A supplementation for overall metabolic health. Positive response from the scientific community to Vannini's research and the potential of urolithin A. RELATED EPISODES▸ Dr. Anurag Singh - Chief Medical Officer, Timeline NutritionBoosting strength, stamina and skin health▸ Dr. Davide D'Amico - Research and Development Group Leader, Timeline NutritionHarnessing nature for better human health▸ Dr. Chris Rinsch - co-founder Amazentis (Timeline parent company) Unlocking the power of advanced nutrition▸ Prof. Patrick Aebischer - Chairman & Co-Founder, Amazentis: A novel molecule to promote longevity▸ Dr. Anurag Singh - Chief Medical Officer with AmazentisPomegranates, muscle mass and healthy aging▸ Dr. Navindra Seeram: The rejuvenating power of plants▸ Prof. Johan Auwerz: The exciting potential of human longevity: ▸ Stephanie Blum: Marketing the science of wellbeing Support the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

The podcast explores the role of Urolithin A in improving muscle strength, skin health, and immune system protection. It delves into the research behind Urolithin A and its potential in slowing down aging. The conversation covers the importance of precision nutrition, individual nutrient levels, and the challenges of finding specific probiotics. The episode discusses the progress made with Mitopure, anecdotal evidence in scientific research, and the benefits of a supplement for boosting mitochondrial health. It also introduces a topical product focused on improving skin health through enhanced mitochondrial function.

The Next Chapter Peter Allison and Peter Bowes – school friends 50 years ago - discuss science-based lifestyle interventions as they pursue the next chapter.  Peter A. has spent much of his life working as a professor of geology in London.  He is a keen diver and keen to optimize his health and vitality to continue with his physically demanding pastime. Peter B. is a journalist and broadcaster with a longtime interest in the science of healthy aging and the hacks we can employ to live life to the full, for as long as possible.In regular conversations they review the latest data that could help us achieve a longer healthspan.  This episode includes:- A study from the University of Barcelona that found a Mediterranean diet rich in healthy fats was associated with reduced cognitive decline in older adults. A Mediterranean Diet-Based Metabolomic Score and Cognitive Decline in Older Adults: A Case–Control Analysis Nested within the Three-City Cohort StudyMolecular Nutrition Food Research journalPublished: 24 October 2023- The study used biomarkers in blood tests to confirm dietary habits, providing more reliable evidence than self-reported diaries.- Potential systemic bias in self-declarations of exercise and diet habits.- The impact of positive mindset on healthy aging, referencing a study that found those with positive beliefs about aging lived longer and had lower blood pressure.People who think positively about getting older often live longer, healthier lives. Here is how to reconsider your perspective.Published:  20 September, 2023- And finally: The centenarian sisters who embrace modern technology and emphasize the importance of movement.Centenarian sisters celebrate life togetherPublished: 22 November, 2023Fit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

As a teenager Chris Mirabile developed a "humble appreciation of life" that turned into a life-long dedication to biohacking and self-experimentation.   He survived a brain tumor at the age of 16 - an experience that piqued his interest in longevity research and eventually to the launch of NOVOS, a nutraceutical company that targets the biological causes of aging to increase longevity.  An appreciation of science and peer-reviewed research has seen Chris emerge as a leading voice in the pursuit of healthy aging and longevity. In this interview we cover:Recovering from a brain tumor - Chris's lightbulb moment.Evolving interest in human longevity - seminal article Cell - Hallmarks of AgingHow an invincible attitude as a teenage morphed into a humbling appreciation of lifeTacking the US Marine Corps benchmark for fitnessNurturing an interest in biohacking through citizen science and self experimentationThe lifestyle interventions to make the biggest impact on healthThe value of strong healthy relationships and social tied to the communityHow our definition of moderation (in everything) is shifting and changingThe value of recovery over pushing too hard to achieve optimum fitnessAdding a billion years of healthy life to humanityHow longevity plays a role in how your lookClarifying the differences between biological and chronological ageRead a transcript:  LLAMA podcast website-Affiliation disclosure: This podcast receives a small commission when you use the code LLAMA for purchases from companies below which support our mission.   It helps to cover production costs and ensures that our interviews, sharing information about human longevity, remain free for all to listen. -Fit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

To what extent do genetics play a role in our ability to live a long healthy life? It is one of the many questions that doctors at the Swiss medical spa, Clinique La Prairie (CLP), consider when assessing someone's state of health and potential longevity.  The clinic adopts a holistic approach to wellbeing - balancing the impact of inherited predispositions to certain conditions, the role of epigenetics - the environment we live in - along with lifestyle factors that also have a powerful impact. To explore these and other issues, LLAMA's Peter Bowes traveled to Montreux in Switzerland to meet CLP's Medical Director, Dr Adrian Heini.  YouTube | LLAMA website: transcript & show notesThis episode is produced in association with Clinique La Prairie with whom the LLAMA podcast shares a common goal of helping people pursue a long healthspan.  The pioneering health and wellness destination, nestled on the shores of Lake Geneva in Montreux, Switzerland, combines preventative medicine with bespoke lifestyle and nutrition plans, and offers a holistic approach to living fuller, healthier, and longer lives.Support the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Peter Allison and Peter Bowes – school friends 50 years ago, now contemplating the next chapter in life - return with another conversation about the latest science that could help us achieve a longer healthspan.In this episode we discuss:Are our longevity goals too perfectionistic? We reflect on an earlier LLAMA podcast interview with Dr. Thomas CurranA National Institutes of Health study, published Oct 13, 2023 in Aging Cell, suggests even a small reduction (12%) in daily calories is beneficial for wellness.  Do you have what it takes to live to 100? An article in The Wall Street Journal by Alex Janin suggests, "It's Not Good Habits; Good genes matter more  the older you get."  How does that impact our attitude towards exercise and other lifestyle hacks to try to optimize healthspan? Read a transcript:  LLAMA podcast website-Affiliation disclosure: This podcast receives a small commission when you use the code LLAMA for purchases from companies below which support our mission.   It helps to cover production costs and ensures that our interviews, sharing information about human longevity, remain free for all to listen. -Fit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Should we be striving to live a perfect life or is it more realistic to aim for one that's "good enough?"  Thomas Curran is an assistant professor of psychology at the London School of Economics and the author of The Perfection Trap: Embracing the Power of Good Enough. He argues that a modern-day pandemic of "perfectionism" is putting people under extreme pressure to be the best they can, at everything.  Prof. Curran says social pressures have resulted in us losing perspective on what it takes to be happy and fulfilled.  Social media images of people seemingly living perfect lives distort reality and are leading to an unhealthy wave of dissatisfaction with our lives. In this interview we explore the implications for those of us pursuing a long life, where healthspan is the goal, rather than lifespan.YouTube | LLAMA website: transcript & show notesThis episode is produced in association with Clinique La Prairie with whom the LLAMA podcast shares a common goal of helping people pursue a long healthspan.  The pioneering health and wellness destination, nestled on the shores of Lake Geneva in Montreux, Switzerland, combines preventative medicine with bespoke lifestyle and nutrition plans, and offers a holistic approach to living fuller, healthier, and longer lives.You may also like:  Are we trying too hard to live perfect lives - March 4, 2019Fit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Peter Allison and Peter Bowes – school friends 50 years ago, now contemplating the next chapter in life - return with another conversation about the latest science that could help us achieve a longer healthspan.In this episode we discuss:New study: Having a lower waist circumference and body mass index is more likely to be associated with exercising between 7 a.m. and 9 a.m. than during midday or evening, according to a new study. Paper: The diurnal pattern of moderate-to-vigorous physical activity and obesity: a cross-sectional analysisJournal: Obesity Pub: Sept 4, 2023Obesity and physical inactivity is very bad for our health but according to  the US Surgeon General Dr. Vivek H. Murthy the mortality impact of being socially disconnected  - i.e  lonely - is an even greater threat to our longevity.  For some, the LA Times reports, supermarket self-checkouts make it worse.Last month the UK's oldest man celebrated his 111th birthday.    John Tinniswood took the opportunity to share some of his rules to live by with healthy aging in mind -  they include "exercising the mind" and "moderation" in all things. Read a transcript:  LLAMA podcast website-Affiliation disclosure: This podcast receives a small commission when you use the code LLAMA for purchases from companies below which support our mission.   It helps to cover production costs and ensures that our interviews, sharing information about human longevity, remain free for all to listen. -Fit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

What does it mean to grow old?  Put another way, what are the hallmarks of aging?  They are questions that have long since intrigued biologists and longevity researchers, with a wide range of theories about what drives the aging process.  We understand the impact of weaker muscles, frailty, cognitive challenges and greying hair, but it is the underlying factors - molecular and cellular mechanisms - that researchers are striving to understand.  Dr. Davide D’Amico, Research and Development Group Leader with the Swiss cellular nutrition brand, Timeline Nutrition, is studying how compounds derived from plants can be used to reverse muscle decline and boost mitochondrial health. In this conversation we cover:- The 'hallmarks of aging,' which refers to the key features of human aging, such as genomic instability and mitochondrial dysfunction.- How the understanding of aging is not simply a chronological process, but also includes the concept of biological aging and the potential for reversing or slowing down this process.- The potential benefits of supplementing with Urolithin A, a compound found in certain foods that can improve mitochondrial health and reduce inflammation.- The importance of muscle strength and physical health in promoting longevity and preventing age-related diseases.- How the ability to convert the precursor molecules found in plants into beneficial compounds like Urolithin A can vary among individuals and is influenced by the diversity and composition of their gut microbiome.- The potential benefits of Urolithin A for the immune system, cartilage health, and overall mobility and quality of life in older adults.- The importance of personalized approaches to health and longevity, with a focus on maintaining quality of life rather than simply extending lifespan.- The overall goal of preventing age-related diseases, supporting optimal health, and promoting a compressed morbidity, where the period of decline in health near the end of life is relatively short.- The need for education and awareness about lifestyle interventions for healthy aging, involving doctors, researchers, politicians, and educators.-DISCOUNTMitopure (a highly pure form of Urolithin A) boosts the health of our mitochondria – the battery packs of our cells – and improves muscle strength. Timeline is offering LLAMA listeners a 10% discount on its range of products – Mitopure powders, softgels & skin creams.  Use the code LLAMA at checkout-Fit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.