Live Long and Master Aging

A key pillar of human longevity is our ability to remain physically strong and active as we age. Frailty is an all-too-familiar downside of growing old. But there is much we can do to slow down and even reverse the process that leads to the weakening of our limbs.  In this episode of the Live Long and Master Aging (LLAMA) podcast, we delve into the latest clinical discoveries that could help us stay strong and vital for much longer. Prof. Stuart Phillips, director of the Physical Activity Centre of Excellence (PACE) at the Department of Kinesiology at McMaster University, Hamilton, Ontario, explains how laboratory research into mitochondrial health is being applied to human physiology. Dr. Phillips is a member of the advisory board of Amazentis, the Swiss life science company, which has partnered with the LLAMA podcast to produce this episode. This episode of the LLAMA podcast is brought to you in association with Amazentis, a Swiss life science company, which is pioneering cutting edge, clinically validated cellular nutrition, under its Timeline brand.Published: October 6, 2020 - 3:21PM PTRecorded: July 7, 2020Visit the LLAMA podcast website for complete show notes, including a transcript of the conversation.In this interview we cover:PACE - a a community access exercise facility for special populations over the age of 55The impact a period of muscular disuse has on the body Why Covid has had such a marked effect on older people through inactivity The classic image of the older, retired person and why the notion of aging being associated with a decline in our physical functions is being challenged. Pursuing a goal of aging as healthily as we can for as long as we can.Understanding the phenomenon of SarcopeniaThe condition known as frailty. Ten thousand steps per day - why that number? Type II diabetes and psychical activity.Working with Amazentis to explore the benefits of Mitopure, a pure form urolithin A, in humans.Making the connection between research in laboratory animals and humans."Lifestyles that give meaning to life.The protein question - how much and what kind? The declining immune system with aging. Why is exercise king and nutrition queen? Is there a recipe for good exercise? Why do we run marathons?The power of walking Spreading the message of healthy aging through social mediaThe Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.Fit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

The science and marketing sectors don’t often intersect. But when clinically validated advancements emerge from the laboratory, this unlikely alliance comes into play.  In this LLAMA podcast episode we explore how cutting edge research can be applied to our everyday health and longevity. Dr. Stephanie Blum, Head of Translational Science at Nestle Health Science, is responsible for transforming  scientific discoveries to innovative product. In partnership with the Swiss life science company, Amazentis, her work involves identifying how Amazentis’ mitochondrial research and clinical trial data can be leveraged for novel nutrition products with proven health benefits.Dr. Blum received her PhD in pharmacology and immunology. She developed a passion for immunology after gaining a complex understanding of how a person’s immune system can critically affect their health.In this interview with Peter Bowes, Dr. Blum discusses the intricacies involved with marketing a science-focused nutrition product. She also reflects on the ways people have changed their health habits in the face of a world-wide pandemic and the steps we could take to increase our immune health, as we age.This episode is produced in association with the Swiss life science company, Amazentis, which is pioneering cutting edge, clinically validated cellular nutrition, under its Timeline brand.Published: September 21, 2020 - 3.09PM PTRecorded: August 12, 2020Visit the LLAMA podcast website for complete show notes, including a transcript of the conversation.In this interview, we cover:Striking a balance between exploring exciting research and actually producing a nutritional supplement that consumers will trust.How a healthy immune system could better-position you to fight off infections.With the COVID pandemic, how a well-functioning immune system is the foundation to defend against a viral or bacterial infection.”Dr. Blum’s conviction that we can proactively contribute to manage our health, and not to wait until medication of an illness is neededWhich kind of health supplements consumers have intensively purchased during the COVID-19 outbreak and how the pandemic has changed their outlook on every-day health habits.Why obesity is a risk factor in COVID-19 infection.What simple thing you can do every day to better strengthen yourself against infections and other illnesses.Why your body accumulates "cellular waste" as you age, and what this means for your health.How offering people a choice in the physical form of a nutritional supplement can make all the difference when it comes to buying into the product and being able to stick with it.The quality that makes you an excellent leader, according to Dr. Blum.The advice Dr. Blum has for rising female leaders and the steps she takes in her personal Fit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

The science of aging is rapidly evolving. Many of us are more aware of our capacity to live a long healthy life, than ever before. But the quest to understand human longevity - and perhaps figure out how we can slow down the process - is still a huge work-in-progress. Why do we age? Is it due to wear and tear on our bodies, is it all predetermined by our genes - or is there an invisible killer all around us, such as toxins in the environment, that is slowly eating away at our lifespan? These and many other compelling questions about aging are explored in a fascinating new book: Borrowed Time: The Science of How and Why We Age, by Sue Armstrong.  In this episode of the Live long and Master Aging podcast, Sue, a writer and broadcaster, based in Edinburgh, joins Peter Bowes to explore the latest research and the lessons to be learned from our growing understanding of what it means to grow old. Published: September 13, 2020 - 07:25 PTRecorded: August 20, 2020Visit the LLAMA podcast website for complete show notes, including a transcript of the conversation.In this interview we cover:Delving into the massive canvas that is the enormous issue of aging, and why it parallels climate change in its importance for the future of mankind. Adding life to years rather than years to life, as the main goal. Why the medical profession is behind the curve on the process of aging.Why the goal of living to over a thousand or even forever is overly “narcissistic."Our genetically predetermined fate, and why plays a relatively small role in our actual lifespan.The centenarians that just keep on going and then die quicklyThe goal of compressed morbidityPeter’s meeting Roy Walford, one of the early proponents of a calorie restricted (CR) lifestyle for longevity. The mixed results from CR experiments involving monkeys. How society and marketing is pushing us into unhealthy lifestyles. The scourge of diseases of the mind and the latest theories on what causes dementia and Alzheimer’s disease.   Ayurveda medicine and a holistic, whole body, approach to treating disease.Could air pollution account for a significant proportion of Alzheimer’s cases? What is inflamm-aging?  Low grade inflation that could be accelerating the aging process.  The lessons to be learned from longevity research. The relaxing, stress-reducing impact of yoga. The aging immune system, the dangers of sitting down for too long.The mindful practice of eating: Why mealtimes should be stress-free and peaceful. The Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.Fit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Eventually, we will all face the challenges that come with old age. We will have less strength and energy than we once had. But what if it were possible to rekindle the drive and physical endurance of youth as we grow older? Prof. Johan Auwerx directs the Laboratory for Integrated and Systems Physiology at École Polytechnique Fédérale (EPFL) in Lausanne, Switzerland, where he studies the mechanisms that control how metabolisms are controlled and the factors that make them more or less effective. Focussing on longevity, his team is using multiple animal species to test a specific compound, Urolithin A, which could potentially restore much-needed muscle strength and energy to people as they age. Prof. Auwerx’s peer-reviewed research, including joint studies with the Swiss life science company, Amazentis, has been published in leading scientific journals. In this LLAMA podcast interview, with Peter Bowes, Prof. Auwerx, discusses the critical need for an affordable solution to ensuring a long and healthy life; how a highly pure form of Urolithin A, known as Mitopure, could be the key to improving our cellular health and strength as we age; and the simple steps we can take to mitigate health issues later in life.This episode is produced in association with Amazentis, which is pioneering cutting edge, clinically validated cellular nutrition, under its Timeline brand.Disclosure: Prof. Auwerx is a scientific adviser to Amazentis and several other companies which make products to boost mitochondrial function. Learn more about the science behind Mitopure, a highly pure form of Urolithin A, from Timeline.Full show notes at the Live Long and Master Aging website.In this interview we cover: The downside of a more sedentary life, either enforced by COVID-19, or as a function of growing old.Why each person’s metabolism functions differently and what this means for our diet.Making the transition from treating patients to medical research.Tackling the big questions regarding metabolic diseases and complex interactions of the human body and the environment. The role of the gut microbiome and genetic makeup in long-term health. Why gaining weight has different implications for the young and old Why people Iiving in one region of the world will digest certain foods more efficiently than people living in a different area.Research with nematode worms (C. elegans) as a model for human aging and longevity.Testing worm observations in human cells, using phenotype data.   How studies on extracts from pomegranates led to a better understanding of Urolithin A.Understanding the difference between healthspan and lifespan. Promoting the benefit of physical activity based oFit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

"Let food be thy medicine and medicine be thy food." The quote, attributed to the Greek physician, Hippocrates, encapsulates the importance of nutrition and the extraordinary ability of certain foods to enhance our wellbeing. In this episode of the LLAMA podcast, we explore the rich array of benefits to be gained from plant foods and natural products and discover why foods rich in compounds known as phytochemicals are hugely beneficial in preventing some chronic conditions. Dr. Navindra Seeram is a professor at the University of Rhode Island, College of Pharmacy.  A leading researcher in the science of plant foods,  Dr. Seeram explains how, growing up in South America, with a tradition of using food as medicine, he first became aware of the potent power of plants.  We delve into the unique components of pomegranate and other fruits, which can be used by the body to boost mitochondrial health.  This LLAMA podcast episode is produced in association with Amazentis, an innovative life science company dedicated to employing breakthrough research and clinical science to bring advanced therapeutic nutrition products to life, under its Timeline brand.Disclosures: Dr. Seeram serves on the scientific advisory board of Amazentis, independently from his position with the University of Rhode Island.  In this interview we cover:Growing up in British Guiana, a poor Third World country, learning about the power of plants as medicines. Developing a career as a natural product chemist.Understanding the anthocyanins or the pigments which make cherries red, blueberries blue, strawberries red and pomegranates red.Defining phytonutrients and phytochemicals.Deriving drugs from natural sources like plants.Revealing the multi-layered qualities of the pomegranate.Trillions of gut bacteria and why they are vital to the way we function.The importance of urolithin A as one of the metabolites we get from pomegranates.Understanding why we respond in different ways to the potentially beneficial compounds found in fruits. Being a responder or a non-responder to Urolithin A.Linking urolithin A to mitochondria - the powerhouse of the cell.  Mitopure™ -  a highly pure form of Urolithin A - and why it has the potential to “cut to the chase,” even for non-responders.Personalized nutrition and precision medicine. Simple diets, spices, coffee and red wine. Healthspan science, long-term wellbeing and reasons to keep on living. The Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.Fit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

The art and science of aging well is a complex business - a nuanced melding of a finely tuned diet, essential exercise and a healthy mind. For over twenty years, Prof. Luigi Fontana has been studying the lifestyle regimes that could help us live a longer, healthier life. One of the world’s leading experts in the field of human longevity, Dr. Fontana, a physician and professor of medicine and nutrition at the University of Sydney, takes a pragmatic approach to the aging process, railing against aspirations to live an excessively long life. The author of ground-breaking research on fasting and nutrition, he explores the wider issues involved in the aging process in a new book, The Path to Longevity: The Secrets to Living a Long, Happy, Healthy Life. In this LLAMA podcast interview, with Peter Bowes, Prof. Fontana argues that medical systems based on treating sick people should be replaced by a more holistic approach to the human body. He also philosophizes about life's "beautiful journey.” In this podcast we cover:Working as a longevity scientists in Australia, a country with free healthcare.The difference between healthcare and sick care. Like unserviced cars, how unhealthy humans are accidents waiting to happen."The scourge of obesity, especially in children and the relationship with chronic disease.  Why living longer by itself is of "no importance"  Finding happiness and harmony in life.The environmental impact of high protein and keto diets.Living long thanks to the longevity gene? The craziness of magical recipes to live longer. The metabolic and molecular pathways that regulate the accumulation of damage.  Calorie restriction (CR) - the most powerful intervention to slow aging.Getting a phone call from CR pioneer Roy Walford. The confusion of ‘intermittent fasting’ describing multiple, disparate regimes.  The limits of using mice and other animals as models for humans in longevity research. The role of IGF-1 - Insulin-like growth factor 1.The 5:2 diet and what we eat on those non-fasting days. Developing biomarkers that measure our response to interventions focussed on improving health.The importance of waist circumference.  The ‘religious’ extremes of longevity - vegetarians, vegans, carnivores.  Approaching aging like a master conductor or a fine artist. A lack of exercise being the main public health problem of the 21st century. Why sportsmen and women do not live particularly long lives. The role of the matters of mind in longevity and pink noise. The value of sleep in healthy aging and memory consolidation. Stress, addictions and dopamine. A philosophical view of iife and longevity.The Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.Fit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

This episode of the Live Long and Master Aging podcast is the first in a series produced in association with the Swiss life science company, Amazentis.  It will explore the history of the company and the science behind its goal of promoting healthy aging. Professor Patrick Aebischer, chairman and co-founder of Amazentis, is a medical doctor, neuroscientist and longtime researcher.  He has held distinguished positions in his home country of Switzerland, as President of the École Polytechnique Fédérale de Lausanne (EPFL) and in the United States at Brown University in Providence.  In this interview we explore how an idea based on little more than “intuition” led to a deeper understanding of muscular strength, as we age, and the role of fruits such as pomegranates. We focus on urolithin A, a bioactive dietary metabolite that is naturally produced when eating certain foods, and how Mitopure, a highly pure, synthetic form of the compound, could help people avoid frailty as they grow older.▸ This episode is produced in association with the Swiss life science company, Amazentis, which is pioneering cutting edge, clinically validated cellular nutrition, under its Timeline brand.▸ Published: Jul 8, 2020 ▸ Read a transcript and additional show notes at the Live Long and Master Aging (LLAMA) podcast website ▸ Also listen and subscribe at Apple Podcasts and You Tube.▸ Listen to related episodes exploring the science behind Urolithin A and MitopureDISCOUNTS▸ Time-line is offering LLAMA podcast listeners a 5% discount on its Mitopure products - Mitopure Powder, Softgels and Mitopure + Protein. Use the code LLAMA at checkout.▸ DoNotAge.org is offering LLAMA podcast listeners a 10% discount on its range of products – NAD boosters, Sirtuin activators, senolytics and more. Use the code LLAMA during checkout at DoNotAge.org  Any health queries can be answered by emailing the team at hello@donotage.org.The Live Long and Master Aging podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.Fit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

We are bombarded with advice and information about diet and exercise, but what about the impact of friendship, optimism and kindness on our longterm wellbeing? It is eye-opening to discover that a strong support network of family and friends lowers mortality risk by about 45 percent, while volunteering your free time reduces the chances of early death by a staggering 20-60 percent, depending on the study. Science journalist Marta Zaraska is the author of Growing Young: How Friendship, Optimism and Kindness Can Help You Live to 100. In this episode of the LLAMA podcast, she discusses the peer-reviewed studies that suggest living to a great age is about more than what we eat or how much we move.  We cover how caring for children motivates us to keep on living and why Marta's long-held beliefs about aging and longevity were shattered through an understanding of the research. Check out our website at LLAMApodcast.com and social media sites @LLAMApodcastIn this episode we cover: Coping with Covid-19 in France, where the outlook is looking better, with no second wave of the virus yet.Becoming a mother and thinking more about health and longevity. Why fixating on nutrition and exercise does not tell the whole story. Delving into the science behind friendship, optimism and kindness. What “Growing Young” means.The folly of “anti-aging."Why hugging and cuddling is good, most of the time.The extremes some people go to for human contact.The blood science that validates acts of kindness as a positive behavioral trail. Oxytocin, serotonin and endorphins. The science behind that fuzzy warm feeling. Fit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

How many times have you heard about an older person doing extraordinary things, despite their great age? In recent weeks the story of the 100-year-old war veteran, Captain Tom Moore, has captivated millions, for his marathon fund raising efforts in the UK. Walking lengths in his garden he has raised more than £30m for the National Health Service, during the Covid-19 crisis. He is amazing. In this episode of the Live Long and Master Aging podcast we explore the lives of amazing people through the eyes of Dr. Noelle Nelson, a California-based psychologist, author of Happy, Healthy...Dead and collector of eye-opening stories through her Facebook page, Meet the Amazings. What are the common traits of older people who live their lives to the full, almost to the end? In this interview we cover:Aspiring to be to be happy, healthy, dead. The lives of the very old - ordinary people doing extraordinary things.Compressed morbidity - reducing the time it takes for the final exit. Why most of Dr. Nelson's longevity achievers are not famous.Joining the dots and connecting the common traits of people who reach a great age. Positivity or optimism: Why it is a major predictor of happy healthy longevity.A passion: From growing tomatoes to looking at the starsA purpose: Sharing knowledge or the joy of competing - in ballroom dancing. Physicality: Walking, climbing, dancing - how exercise has been shown to improve mind and body functioning. The power of always looking forward. The value of friends - or “anchors" - to get through life’s tough times. Dealign with losing everything in one of California’s wildfires. The value of please and thank you and self appreciation. Exploring science-based lifestyle interventions to live better.Editor’s note: This episode of the LLAMA podcast was recorded in Camarillo, California, on February 27th, 2020, three weeks before the state became the first in the U.S. to issue a stay at home order due to the coronavirus.The Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.  Fit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

We are in the war against Covid-19 for the long term. The virus is likely to be with us for many months, if not years, and as we emerge from the global lockdowns, everyday life is looking very different. Re-imagining a post-coronavirus world will likely involve changes that go to the heart of how we live - our diet, personal hygiene, social behavior and work/life balance.  As we learn more about the virus, it is becoming clear that a healthy body is a vital prerequisite to fighting the disease.  In this episode of the Live Long and Master Aging podcast, Dr. Aseem Malhotra, a London-based cardiologist, explains why he believes obesity is a prime risk factor for mortality from Covid-19.  He also suggests that the pandemic should act as a wake-up call for global populations, pursuing unhealthy lifestyles, consuming too much sugar and processed foods.Dr Aseem Malhotra is a National Health Service (NHS) Consultant Cardiologist in the UK, and visiting Professor of Evidence Based Medicine, Bahiana School of Medicine and Public Health, Salvador, Brazil. In the episode we cover: How a "horrendous state” of baseline general health, in many western populations, is relevant to Covid-19Ref. European Scientist: Covid 19 and the elephant in the room (April 16, 2020)The myths surrounding the health of people in Mediterranean countries. What is optimal metabolic health? Blood pressure, waist circumference, blood triglyceride, HDL, and HbA1c levels.Nature:  Endocrine and metabolic link to coronavirus infection (April 2nd, 2020)Lifestyle lessons from Covid-19.Personal hygiene and why it matters. Imagining the post-coronavirus world.  Listen to Dr. Malhotra’s previous LLAMA podcast interviewEpisode 03: Waging war against sugarThe Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.Fit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.