We're not getting any younger... yet.

After a wide-ranging conversation with Nir Barzilai, Gordon and show editor Stella discuss efforts to turn research on geroprotective mechanisms into effective interventions, and look forward to the next episode with neuroscientist Monica Driscoll.Support the show

Is aging truly inevitable? Can we study the genetics of long-lived people to learn how to delay or reverse aging? In this episode, Gordon talks with Dr. Nir Barzilai about his research on centenarians, insulin signaling pathways, and moving aging interventions out of the lab and into the clinic. Support the show

Gordon and show editor Stella revisit key concepts from the conversation with Linda Partridge, such as what we can learn from evolutionary biology and how to harness biological processes like autophagy. Looking ahead, they anticipate discussing human clinical trials in the next episode with Nir Barzilai.Support the show

Aging appears to progress similarly across species, from worms and flies to mice and humans, and involves pathways related to early development. Guest Linda Partridge talks with Gordon while visiting the Buck Institute to discuss the evolutionary trade offs of aging mechanisms, the role of nutrient-sensing pathways, and how we might get the most benefit from preventative interventions in midlife.Support the show

Following the episode with Rhonda Patrick, Gordon and Stella discuss the complex relationship between stress and aging, and preview the next conversation with Linda Partridge.The show will return in January 2023. Happy Holidays!Support the show

What is the relationship between stress, metabolism, and aging? How can we use “good” stress to enhance our ability to weather the challenges of getting older? Guest Rhonda Patrick has investigated the biology of aging and related lifestyle interventions throughout her multifaceted career. In this episode she joins Gordon to explore insights from studies on nutrition, exercise, inflammation, psychological stress, and more, as well as the crucial role of science communicators in today’s media.Support the show

Gordon and Stella revisit the discussion with Judy Campisi to understand the role senescence plays in aging, and look forward to the next conversation with longevity expert Rhonda Patrick.Support the show

Dr. Campisi has been at the forefront of studying cellular senescence for decades, revealing the mysteries of these not-exactly-dead cells and their role in many diseases of aging. In this episode, she joins her colleague Gordon to discuss the characteristics and function of senescent cells, as well as promising interventions on the horizon. Judy also describes how to get lucky in science by being prepared to see the unexpected.Support the show

Gordon and show editor Stella revisit highlights from the conversation with David Sinclair, and get ready for the next episode with Judy Campisi.Support the show

Is life essentially an information process driven by biochemical interactions? If so, can we simply correct any errors in that process? In this episode, renowned researcher and author David Sinclair joins Gordon to dive into the startling insights from applying information theory to aging. Topics include epigenetics, sirtuins, metabolism, and why we might not want to kill all the zombies. Support the show