Research To Practice | Oncology Videos

Featuring perspectives from Dr Nancy Lin, including the following topics: Introduction: Journal Club with Nancy U Lin, MD (0:00) Case: A woman in her late 60s with ER-positive, HER2-positive breast cancer who has significant neuropathy and develops liver metastases after adjuvant docetaxel/carboplatin/trastuzumab — Laurie Matt-Amaral, MD, MPH (15:30) Case: A woman in her late 80s with weakly ER-positive, PR-negative, HER2-positive, gBRCA2 mutation-positive T2N1M0 breast cancer after neoadjuvant paclitaxel/trastuzumab — Zanetta S Lamar, MD (20:16) Case: A woman in her early 50s with ER/PR-negative, HER2-positive metastatic breast cancer (mBC) with progressive brain metastases after T-DM1 and whole braid radiation therapy — Justin Peter Favaro, MD, PhD (31:06) Case: A woman in her late 40s with triple-positive breast cancer after resection of brain metastasis — Shaachi Gupta, MD, MPH (37:26) Case: A woman in her mid 60s with ER/PR-positive, HER2-low mBC after endocrine therapy-based treatments, capecitabine — Vignesh Narayanan, MD (46:44) Case: A woman in her early 60s with progressive triple-positive mBC receiving T-DXd — Joseph Martins, MD (54:36) CME information and select publications

Featuring a slide presentation and related discussion from Prof Sia Daneshmand, including the following topics: Continuous intravesical drug delivery for patients with muscle-invasive urothelial bladder cancer (MIBC) (0:00) Current role of checkpoint inhibitors alone or in combination with chemotherapy for urothelial bladder cancer (UBC) (9:26) Emerging data with novel agents and strategies for the management of UBC (14:52) Case: A man in his mid 70s with a history of high-grade T1 disease who is not a good candidate for cystectomy (18:57) Case: A man in his early 80s with high-grade T2 MIBC who is not a candidate for cystectomy or neoadjuvant chemotherapy (22:27) Case: A woman in her late 50s with completely resected UBC with a strong preference for bladder-sparing treatment (24:43) CME information and select publications

Featuring an interview with Prof Sia Daneshmand, including the following topics: Clinical presentation and initial evaluation of non-muscle-invasive urothelial bladder cancer (NMIBC) (0:00) Alternative induction regimens when BCG is not available (4:06) Treatment options for patients with BCG-refractory disease (8:46) Role of immunotherapy in treating NMIBC (13:58) Role of cystectomy in treating NMIBC (15:47) Intravesical drug delivery for patients with muscle-invasive urothelial bladder cancer (MIBC) (20:37) Dispelling myths and misperceptions about cystectomy and counseling eligible patients (26:19) Neoadjuvant and adjuvant therapy for MIBC (37:40) CME information and select publications

Featuring perspectives from Drs Guillermo Garcia-Manero, Gail Roboz and David Sallman, including the following topics: Prologue: A vision for the future (0:00) Classification and prognosis of myelodysplastic syndromes (MDS) (23:34) Current management of lower-risk MDS (25:57) Current management of higher-risk MDS (38:16) MDS-Acute Myeloid Leukemia continuum and overlap: Venetoclax and other targeted therapy (46:38) CME information and select publications

Featuring perspectives from Dr Carl Gay, including the following topics: Introduction: Journal Club with Carl M Gay, MD, PhD (0:00) Case: A woman in her early 60s with extensive-stage small cell lung cancer (ES-SCLC) and a small residual lung mass after carboplatin/etoposide/atezolizumab — Kapisthalam (KS) Kumar, MD (19:15) Case: A woman and heavy smoker in her early 70s who develops widespread ES-SCLC after chemotherapy/radiation therapy for limited-stage SCLC — Neil Morganstein, MD (24:24) Case: A man in his mid 60s with ES-SCLC and disease progression after carboplatin/etoposide/atezolizumab with central nervous system metastases (FGFR1 gain, tumor mutational burden 11 mut/Mb) who receives lurbinectedin/radiation to the brain — Adam R Miller, MD (38:36) Case: A man in his early 60s with progressive ES-SCLC s/p carboplatin/atezolizumab on lurbinectedin with dose adjustment — Rohit Gosain, MD (47:38) Case: A woman and current smoker in her early 70s with ES-SCLC who receives dose-attenuated chemoimmunotherapy due to multiple comorbidities — Minesh Dinubhai Patel, MD (58:09) CME information and select publications

Featuring perspectives from Dr Stephanie Lheureux, including the following topics: Prologue: Seminars in Cancer Biology (0:00) Case: A woman in her mid 50s with Stage IVB BRCA wild-type, HR-proficient primary peritoneal cancer — Dana M Chase, MD (10:54) Case: A woman in her mid 70s with recurrent platinum-sensitive peritoneal cancer (Lynch, VUS) and a gBRCA2 mutation— Karim ElSahwi, MD (32:33) Case: A woman in her early 60s with ovarian cancer and prolonged pancytopenia after treatment with a PARP inhibitor — Joseph Martins, MD (38:51) Case: A woman in her mid 60s with platinum-resistant recurrence of BRCA wild-type clear cell ovarian cancer after carboplatin/paclitaxel/bevacizumab and maintenance bevacizumab (homologous recombination deficiency [HRD] negative) — Neil Morganstein, MD (43:21) Case: A woman in her early 60s with multiregimen-recurrent BRCA wild-type, HRD-negative metastatic ovarian cancer — Rahul Gosain, MD (47:44) Case: A woman in her late 60s with recurrent platinum-resistant, BRCA wild-type, HR-proficient ovarian cancer after receiving paclitaxel/tumor treating fields on a clinical trial — Dr Chase (52:07) CME information and select publications

Featuring perspectives from Dr Robert Haddad, including the following topics: ESMO 2022 (0:00) Case: A man in his early 50s presents with metastatic anaplastic thyroid cancer — Ezra Cohen, MD (18:39) Case: A man in his late 60s who has undergone immunotherapy for melanoma is diagnosed with Stage I (cN2 N1) p16-positive squamous cell carcinoma (SCC) of the left tonsil — Erik Rupard, MD (26:21) Case: An Asian woman in her early 40s who has received cisplatin/radiation therapy and gemcitabine/cisplatin for locoregionally advanced nasopharyngeal cancer develops metastatic disease (PD-L1 CPS 10) — Dr Cohen (31:21) Case: A man in his early 70s presents with recurrent and rapidly progressing HPV-negative metastatic head and neck cancer — Neil Morganstein, MD (38:55) Case: A man in his late 50s who has undergone definitive radiation therapy and surgery for locally recurrent SCC of the head and neck presents with worsening shortness of breath — Mamta Choksi, MD (41:42) Case: A man in his early 70s with a longstanding history of T-cell large granular lymphocytic leukemia presents with metastatic HPV-positive SCC of the left nostril (PD-L1-negative) — Spencer H Bachow, MD (44:50) Case: A man in his late 50s presents with HPV-positive Stage III cancer of the base of the tongue — Dr Cohen (49:03) Case: A man in his early 70s presents with metastatic anaplastic thyroid cancer (PD-L1-positive, mutations in TERT promoter, PT53 and MEN1) — Dr Rupard (52:00) Case: A man in his early 60s presents with metastatic papillary thyroid cancer with a BRAF V600E mutation — Dr Cohen (56:16) CME information and select publications

Featuring a slide presentation and related discussion from Dr Benjamin Levy, including the following topics: Immune checkpoint inhibitors for treatment-naïve extensive-stage small cell lung cancer (ES-SCLC) (0:00) Evaluating the role of lurbinectedin in therapy for SCLC (9:32) Impact of trilaciclib on myelosuppression in patients with ES-SCLC (19:08) Novel treatment strategies for patients with SCLC (22:14) CME information and select publications

Featuring perspectives from Dr Benjamin Levy, including the following topics: Disease biology of and therapeutic strategies for small cell lung cancer (SCLC) (0:00) Current and future management of limited-stage SCLC (3:32) Case: A man in his mid 70s with newly diagnosed SCLC and isolated brain metastases (5:51) Novel therapies for SCLC (21:51) Future directions for lurbinectedin in the treatment of SCLC (25:54) Case: A man in his late 40s with no smoking history diagnosed with adenocarcinoma of the lung with EGFR exon 19, TP53 and RB1 mutations and small cell transformation apparent on repeat biopsy (29:54) Case: A man in his mid 50s with a heavy smoking history diagnosed with SCLC and disease progression after anti-PD-L1 monotherapy (36:25) Expanding immunotherapy options for the treatment of SCLC (41:07) Palliative and supportive services for patients with SCLC (44:21) CME information and select publications

Featuring an interview with Dr Michael Birrer, including the following topics: Prologue (0:00) Multidisciplinary Management of Endometrial Cancer in Copenhagen, Denmark; Boston, Massachusetts and Little Rock, Arkansas (6:17) Subtypes of Endometrial Cancer (12:51) Treatment for Microsatellite Instability-High Endometrial Cancer (16:27) Microsatellite-Stable Endometrial Cancer (37:26) Future Directions in the Treatment of Endometrial Cancer (49:29) CME information and select publications