

The Root Cause Medicine Podcast
Rupa Health
In each episode, we’ll meet renowned medical experts, specialists and pioneers who’ve influenced the way certain conditions and diseases are understood and treated. We focus on giving you the information you need to understand the root cause, symptoms and treatments available for specific medical conditions.
Episodes
Mentioned books

Mar 4, 2025 • 59min
The Story of 3x4 Nutrigenomic Testing Dr. Yael Joffe
In today's episode of The Root Cause Medicine Podcast, Dr. Yael Joffe joins Dr. Kate Kresge to discuss her remarkable journey from architecture student to nutrigenomics pioneer, driven by a personal loss that left her searching for answers. You’ll hear us discuss:
The role of genetic insights in supporting personalized wellness approaches
3X4 Genetics innovative approach to genetic testing
The challenges of bringing genetics into clinical practice
How AI might reshape the field
Dr. Joffe is a pioneering figure in nutrigenomics and the founder of 3X4 Genetics. Originally from South Africa, she began her career studying architecture before pivoting to dietetics following her grandmother's battle with cancer. Driven to understand the intersection of genetics and nutrition more deeply, she pursued a PhD in genetics while working full-time. Throughout her career, Dr. Joffe has been instrumental in developing nutrigenomic testing methodologies, including the Darwin methodology used by 3X4 Genetics to analyze genetic markers for potential insights in personalized wellness. Additionally, Dr. Joffe is the author of The Power Of Genetics.
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9 snips
Feb 27, 2025 • 53min
Beat the Menopause Brain Fog with Dr. Lisa Moscono: Episode Rerun
Dr. Lisa Mosconi, an influential neuroscientist and leader in Alzheimer's prevention, sheds light on the effects of menopause on brain health. She discusses the cognitive challenges and brain fog many women experience during this transition. The conversation emphasizes the significance of sleep disturbances and offers practical strategies for managing menopause symptoms, including lifestyle adjustments and exercise. Dr. Mosconi also advocates for more research on women’s brain health to address these unique concerns.

Feb 25, 2025 • 50min
The Link Between Hormones, Pregnancy, Menopause & Your Teeth with Dr. Leedia Riman
Dr. Leedia Riman is a holistic dentist specializing in women's oral health through various life stages. She discusses the surprising link between hormonal shifts during pregnancy and dental health, revealing that over 65% of women face dental issues during or after pregnancy. Dr. Riman emphasizes the role of hormones in oral dysbiosis and its connection to gut health. With practical oral care strategies, she advocates for tailored approaches to women's dental hygiene and the importance of integrating dental and medical care for optimal wellness.

Feb 21, 2025 • 1h 5min
The Science and Myths of the Paleo Diet with Trevor Connor and Dr. Griffin McMath
In today's episode of The Root Cause Medicine Podcast, Dr. Kate Kresge sits down with Trevor Connor and Dr. Griffin McMath of The Paleo Diet to explore why the Paleo diet is more relevant than ever in today's world of extreme dieting.
You'll hear them discuss:
1. How modern food processing has introduced foods our bodies aren't designed to digest
2. How grains, dairy, and ultra-processed foods may impact overall health and digestion
3. The health benefits of following a paleo lifestyle
4. How the paleo diet supports sustainability, budget-friendly eating, and even brain health
5. The practical aspect of adopting a paleo diet
Trevor is the CEO of The Paleo Diet and Co-Founder of Fast Talk Laboratories. A former professional cyclist who competed until age 53, his journey with the paleo diet began when he was a student at CSU studying under Dr. Loren Cordain, the diet's originator. Initially skeptical, his attempts to disprove the diet's principles led him to become one of its strongest advocates after experiencing significant improvements in his own health and athletic performance.
Dr. Griffin is a key figure at The Paleo Diet organization, bringing her background in anthropology and integrative healthcare to the team. She has worked in integrative oncology and various healthcare settings, focusing on making the paleo lifestyle accessible and practical for diverse populations. Additionally, Dr. Griffin is a Co-Host of the Fast Talk Podcast. Previously, she was an Executive Director at the Institute for Natural Medicine.
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Feb 19, 2025 • 50min
Tackling ADHD, Anxiety, and Insomnia with Dr. Romie Mushtaq: Episode Rerun
In today's episode of The Root Cause Medicine Podcast, we shed light on adult ADHD, stress-success cycle, burnout, anxiety, and insomnia and how they can all be addressed using a root-cause approach with Dr. Romie Mushtaq. You’ll hear us discuss:
How stress and anxiety impact adult-onset ADHD
The "busy brain" and how it relates to anxiety, attention issues, and insomnia
The role of chronic stress in neuroinflammation and ADHD
How to manage ADHD symptoms through diet
"The Busy Brain Cure" book
Dr. Romie is an experienced neurologist and the author of "The Busy Brain Cure." With over 20 years in the field, she also serves as the Chief Wellness Officer at Evolution Hospitality and is the CEO and Founder of brainSHIFT Institute. Dr. Romie combines her extensive experience in neurology, integrative medicine, and mindfulness to offer impactful programs and drive cultural transformation.
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Feb 13, 2025 • 56min
The Science of Brain Health and How to Protect it with Dr. Austin Perlmutter: Episode Rerun
In today's episode of The Root Cause Medicine Podcast, we explore the often-overlooked importance of brain health and how it directly impacts our quality of life with Dr. Austin Perlmutter. You’ll hear us discuss:
1. Brain inflammation
2. Brain-related conditions in women
3. Detoxification and brain health
4. Lifestyle choices supporting brain health
5. Supplements for brain health
Dr. Austin Perlmutter is a board-certified internal medicine physician, a New York Times bestselling author, and a published researcher. He is also a health investor and international educator dedicated to helping people improve their health by addressing the biological roots of "stuckness" in the brain and body. Currently, Dr. Perlmutter serves as the executive director and research lead at Big Bold Health.
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Feb 11, 2025 • 44min
How to Calm Your Nervous System for Better Health with Dr. Cathleen King
In today's episode of The Root Cause Medicine Podcast, Dr. Carrie Jones sits down with Dr. Cathleen King to explore how supporting nervous system health may play a role in overall well-being, stress management, and resilience. You'll hear us discuss:
1. Why the nervous system plays a key role in overall function
2. How trauma and stress may contribute to physical symptoms
3. The connection between nervous system regulation and overall well-being
4. Steps that may support nervous system balance and resilience
5. How breath work and vagal tone can influence relaxation and stress response
Dr. Cathleen King is a Doctor of Physical Therapy and a qualified Neuroplasticity Educator who has personally navigated the challenges of complex trauma and illness. As the founder of Primal Trust, she developed a unique approach that combines top-down brain retraining with bottom-up somatic and vagus nerve support. Featured in The Inside Effects documentary as a thought leader in mind-body wellness, Dr. King has guided thousands of clients and health professionals in techniques to support brain function and nervous system regulation.
Considering lab testing? Rupa Health provides access to functional medicine lab tests from 30+ labs. Always consult with a qualified healthcare provider before ordering tests to determine what is appropriate for your individual needs. https://www.rupahealth.com/reference-guide

Feb 6, 2025 • 57min
Dr. Anthony Youn's Natural Skin Health Approaches for a Youthful Look with Dr. Anthony Youn: Episode Rerun
In today's episode of The Root Cause Medicine Podcast, we explore holistic approaches to aging and improving skin health without invasive procedures with Dr. Anthony Youn. You’ll hear us discuss:
1. How to enhance skin health and appearance naturally
2. The role of nutrition and supplements in aging
3. Achieving youthful skin without invasive procedures
4. The 21-Day NEW YOU Jumpstart program for healthy aging
5. Dr. Youn's skincare routine for youthful skin
With his unique ability to approach beauty, Dr. Anthony Youn is known as America's Holistic Plastic Surgeon®. He is a board-certified and nationally recognized plastic surgeon and the most followed in his field on social media, with over 5 million YouTube subscribers and 8 million TikTok followers. Recognized as a leader in his field, he is the author of several best-selling books, including the newly released "Younger for Life."

Feb 4, 2025 • 52min
GLP-1s and SPMs: Advances in Personalized Nutrition with Ashley Koff
In today's episode of The Root Cause Medicine Podcast, Dr. Kate Kresge sits down with Ashley Koff, RD, CEO and Founder of The Better Nutrition Program, to explore the role of GLP-1 receptor agonists and specialized pro-resolving mediators (SPMs) in health and wellness.
You'll hear them discuss:
• How GLP-1 receptor agonists may support metabolic health when used under the guidance of a healthcare provider.
• The role of SPMs in supporting the body's natural inflammatory response and recovery processes.
• The connection between nutrition and mental well-being.
• How personalized nutrition considers individual needs, preferences, and health factors.
Ashley is a registered dietitian with over 25 years of experience in personalized nutrition. She is known for her evidence-based approach to nutrition and has been recognized as one of CNN’s Top 100 Health Makers."
Considering lab testing? Rupa Health provides access to functional medicine lab tests from 30+ labs. Always consult with a qualified healthcare provider before ordering tests to determine what is appropriate for your individual needs. https://www.rupahealth.com/reference-guide

Jan 30, 2025 • 43min
Autoimmune Diseases: Trauma, Gut Health, and Psychedelic Therapies with Dr. Sara Szal Gottfried: Episode Rerun
In today's episode of The Root Cause Medicine Podcast, we dive into autoimmune diseases with Dr. Sara Szal Gottfried based on her new book, The Autoimmune Cure. You’ll hear us discuss:
1. The root causes of autoimmune disease
2. How trauma acts as a trigger for autoimmune diseases
3. Leaky gut and autoimmune diseases
4. Psychedelic medicine for treating autoimmune diseases
5. The gut-immune system connection in autoimmune diseases
6. Her newest book, The Autoimmune Cure
Dr. Sara is a Harvard-trained medical doctor with over 25 years of experience, a distinguished scientist, and a dedicated researcher. Known for her role in bridging connections in the medical field, she is both a scholar and a seeker of knowledge. Dr. Sara has authored four New York Times bestselling books, including "The Autoimmune Cure." Her mission is to transform healthcare into a more personalized approach, highlighting telehealth services for executives, elite athletes, and VIPs. Additionally, she serves as the Director of Precision Medicine at the Marcus Institute of Thomas Jefferson University Hospitals.
Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide


